Vitamin D Represses Dentin Matrix Protein 1 in Cementoblasts and Osteocytes

Nociti, F.H.; Foster, B.L.; Tran, A.B.; Dunn, D.; Presland, R. B.; Wang, L.; Bhattacharyya, N.; Collins, M.T.; Somerman, M.J.

doi:10.1177/0022034513516344

Cited by 35Parathyroid Disorders and TreatmentsVitamin D Research StudiesBone and Dental Protein Studies

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Vitamin D Represses Dentin Matrix Protein 1 in Cementoblasts and Osteocytes

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Nociti, F.H., Foster, B.L., Tran, A.B., Dunn, D., Presland, R. B., Wang, L., Bhattacharyya, N., Collins, M.T., Somerman, M.J.·2014·Journal of Dental Research

DOI 10.1177/0022034513516344PMC PMC6728571

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Abstract

Calcium and phosphorus homeostasis is achieved by interplay among hormones, including 1,25(OH) 2 D 3 (1,25D), parathyroid hormone, and fibroblast growth factor 23 (FGF23), and their interactions with other proteins. For example, mutations in dentin matrix protein 1 (DMP-1) result in increased FGF23 and hypophosphatemic rickets. 1,25D is reported to modulate FGF23; thus, we hypothesized that 1,25D may be involved in modulating DMP-1 in an intermediary step. Murine cementoblasts (OCCM-30) and osteocyte-like cells (MLO-Y4 and MLO-A5), known to express DMP-1, were used to analyze effects of 1,25D on DMP-1 expression in vitro. DMP-1 mRNA levels decreased by 50% ( p < .05) in the presence of 1,25D in all cell types, while use of a vitamin D receptor (VDR) agonist (EB1089) and antagonist (23S,25S)-DLAM-2P confirmed that VDR pathway activation was required for this response. Further analysis showed that histone deacetylase recruitment was necessary, but neither protein kinase A nor C pathways were required. In conclusion, our results support the hypothesis that 1,25D regulates DMP-1 expression through a VDR-dependent mechanism, possibly contributing to local changes in bone/tooth mineral homeostasis.

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1,25(OH)2D3 modulates matrix mineralization by downregulating dentin matrix protein-1 (DMP-1).
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Authors: Nociti, F. H., Foster, B. L., Tran, A. B., Dunn, D., Presland, R. B., Wang, L., Bhattacharyya, N., Collins, M. T., & Somerman, M. J.
Affiliations: National Institutes of Health (US)
University of Washington (US)
Corresponding author: Somerman, M.J.
ORCID: Nociti, F.H.
Foster, B.L.
Presland, R. B.
Collins, M.T.
Somerman, M.J.
Venue: Journal of Dental Research
Publisher: SAGE Publications
Published: 2013-12-11
Volume: 93
Issue: 2
Pages: 148-154
ISSN: 0022-0345 (ISSN-L)
1544-0591
DOI: 10.1177/0022034513516344
PMC: PMC6728571
OpenAlex: W2053797304
Cited by: 35
References: 31
Citations by year: 2026: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2019: 2 · 2018: 2 · 2017: 8 · 2016: 4 · 2015: 5 · 2014: 3
FWCI: 3.03
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Dental Research (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Keywords: vitamin D, 1,25-dihydroxyvitamin D3, DMP1, vitamin D receptor, cementoblasts, osteocytes, histone deacetylase, calcium and phosphorus homeostasis, fibroblast growth factor 23, hypophosphatemic rickets, bone mineral homeostasis, tooth mineralization
MeSH terms: Vorinostat, Fibroblast Growth Factor-23, Animals, Calcitriol, Cell Line, Dental Cementum, Dose-Response Relationship, Drug, Estrenes, Fibroblast Growth Factors, Flavonoids, Histone Deacetylases, Hydroxamic Acids, Indoles, Maleimides, Osteocytes, Type C Phospholipases, Protein Kinase C, Pyrrolidinones, Vitamins, Down-Regulation, Extracellular Matrix Proteins, Calcium-Calmodulin-Dependent Protein Kinases, Receptors, Calcitriol, MAP Kinase Signaling System, Mice, Histone Deacetylase Inhibitors

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Vitamin D Represses Dentin Matrix Protein 1 in Cementoblasts and Osteocytes

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