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Cited by 249Dental Health and Care UtilizationEndodontics and Root Canal TreatmentsDental materials and restorations

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Randomized Clinical Trial of 12% and 38% Silver Diamine Fluoride Treatment

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Fung, M.H.T., Duangthip, D., Wong, M.C.M., Lo, E.C.M., Chu, C.H.·2018·Journal of Dental Research
DOI 10.1177/0022034517728496PMC PMC6429575
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Abstract

This 30-mo randomized clinical trial compared the effectiveness of 2 concentrations (12% or 38%) of silver diamine fluoride (SDF) and 2 periodicity of application (once or twice a year) in arresting cavitated dentin caries in primary teeth. Children aged 3 to 4 y who had at least 1 active cavitated caries lesion were enrolled and randomly allocated into 4 groups for intervention. Group 1 had 12% SDF applied annually (every 12 mo), group 2 had 12% SDF applied semiannually (every 6 mo), group 3 had 38% SDF applied annually, and group 4 had 38% SDF applied semiannually. Clinical examinations were performed semiannually in kindergarten by a single examiner to investigate whether the SDF-treated caries became arrested. A total of 888 children with 4,220 decayed tooth surfaces received SDF application at baseline, and 799 (90.0%) children with 3,790 surfaces (89.8%) were evaluated at the 30-mo examination. The caries arrest rates were 55.2%, 58.6%, 66.9%, and 75.7% for groups 1, 2, 3, and 4, respectively ( P < 0.001). Caries treated with 38% SDF had a higher chance of becoming arrested than those treated with 12% SDF (odds ratio [OR], 1.98; 95% confidence interval [CI], 1.51-2.60, P < 0.001). The interaction between frequency of SDF application and visible plaque index (VPI) score was significant ( P = 0.017). Among those children who received annual SDF application, children with a higher VPI score had a lower chance to have their caries become arrested (OR, 0.59, 95% CI, 0.49-0.72). In conclusion, SDF at a concentration of 38% is more effective than that of 12% in arresting active caries in primary teeth. For children with poor oral hygiene, caries arrest rate of SDF treatment can be increased by increasing the frequency of application from annually to semiannually ( ClinicalTrials.gov NCT02385474).

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Research works printed but not linked: 3

  1. Ainamo J, 1975, Int Dent J, 25, 229
  2. Horst JA, 2016, J Calif Dent Assoc, 44, 16
  3. Nelson T, 2016, Pediatr Dent, 38, 212

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Metadata

Authors
Fung, M. H. T., Duangthip, D., Wong, M. C. M., Lo, E. C. M., & Chu, C. H.
Affiliations
University of Hong Kong (HK)
Corresponding author
Chu, C.H.
ORCID
Venue
Journal of Dental Research
Publisher
SAGE Publications
Published
2017-08-28
Volume
97
Issue
2
Pages
171-178
ISSN
  • 0022-0345 (ISSN-L)
  • 1544-0591
DOI
10.1177/0022034517728496
PMC
PMC6429575
OpenAlex
W2750360976
Cited by
249
References
23
Citations by year
2026: 14 · 2025: 33 · 2024: 49 · 2023: 31 · 2022: 31 · 2021: 28 · 2020: 32 · 2019: 15 · 2018: 15 · 2017: 1
FWCI
23.77
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Dental Research (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Topics
  • Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
  • Health Sciences › Dentistry › Oral Surgery › Endodontics and Root Canal Treatments
  • Health Sciences › Dentistry › General Dentistry › Dental materials and restorations
Keywords
silver diamine fluoride, caries arrest, primary teeth, dentin caries, treatment frequency, visible plaque index, oral hygiene, children, pediatric dentistry, fluoride varnish, secondary caries, dental caries prevention, caries remineralization
MeSH terms
Quaternary Ammonium Compounds, Cariostatic Agents, Child, Preschool, Dental Caries, Female, Fluorides, Topical, Hong Kong, Humans, Male, Tooth, Deciduous, Treatment Outcome, Silver Compounds

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