Cited by 249Dental Health and Care UtilizationEndodontics and Root Canal TreatmentsDental materials and restorations

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Randomized Clinical Trial of 12% and 38% Silver Diamine Fluoride Treatment

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Fung, M.H.T., Duangthip, D., Wong, M.C.M., Lo, E.C.M., Chu, C.H.·2018·Journal of Dental Research

DOI 10.1177/0022034517728496PMC PMC6429575

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Abstract

This 30-mo randomized clinical trial compared the effectiveness of 2 concentrations (12% or 38%) of silver diamine fluoride (SDF) and 2 periodicity of application (once or twice a year) in arresting cavitated dentin caries in primary teeth. Children aged 3 to 4 y who had at least 1 active cavitated caries lesion were enrolled and randomly allocated into 4 groups for intervention. Group 1 had 12% SDF applied annually (every 12 mo), group 2 had 12% SDF applied semiannually (every 6 mo), group 3 had 38% SDF applied annually, and group 4 had 38% SDF applied semiannually. Clinical examinations were performed semiannually in kindergarten by a single examiner to investigate whether the SDF-treated caries became arrested. A total of 888 children with 4,220 decayed tooth surfaces received SDF application at baseline, and 799 (90.0%) children with 3,790 surfaces (89.8%) were evaluated at the 30-mo examination. The caries arrest rates were 55.2%, 58.6%, 66.9%, and 75.7% for groups 1, 2, 3, and 4, respectively ( P < 0.001). Caries treated with 38% SDF had a higher chance of becoming arrested than those treated with 12% SDF (odds ratio [OR], 1.98; 95% confidence interval [CI], 1.51-2.60, P < 0.001). The interaction between frequency of SDF application and visible plaque index (VPI) score was significant ( P = 0.017). Among those children who received annual SDF application, children with a higher VPI score had a lower chance to have their caries become arrested (OR, 0.59, 95% CI, 0.49-0.72). In conclusion, SDF at a concentration of 38% is more effective than that of 12% in arresting active caries in primary teeth. For children with poor oral hygiene, caries arrest rate of SDF treatment can be increased by increasing the frequency of application from annually to semiannually ( ClinicalTrials.gov NCT02385474).

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CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials
Moher, D., Hopewell, S., Schulz, K. F., Montori, V., Gotzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2010) · BMJ · doi:10.1136/bmj.c869 · Cited by 8,883
Problems and proposals for recording gingivitis and plaque.
Ainamo, J., & Bay, I. (1975) · PubMed · Cited by 3,022
Global Burden of Untreated Caries: A Systematic Review and Metaregression
Kassebaum, N. J., Bernabé, E., Dahiya, M., Bhandari, B., Murray, C. J. L., & Marcenes, W. (2015) · Journal of Dental Research · doi:10.1177/0022034515573272 · Cited by 1,679
Applied Multilevel Analysis
Twisk, J. W. R. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511610806 · Cited by 861
Silver Diamine Fluoride: A Caries “Silver-Fluoride Bullet”
Rosenblatt, A., Stamford, T. C. M., & Niederman, R. (2009) · Journal of Dental Research · doi:10.1177/0022034508329406 · Cited by 546
Effectiveness of Silver Diamine Fluoride and Sodium Fluoride Varnish in Arresting Dentin Caries in Chinese Pre-school Children
Chu, C. H., Lo, E. C. M., & Lin, H. (2002) · Journal of Dental Research · doi:10.1177/0810767 · Cited by 477
Self-citation
UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications and Consent
Horst, J. A., Ellenikiotis, H., & Milgrom, P. L. (2016) · Journal of the California Dental Association · doi:10.1080/19424396.2016.12220962 · Cited by 426
Caries remineralisation and arresting effect in children by professionally applied fluoride treatment – a systematic review
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Self-citation
Randomized clinical trial on effectiveness of silver diamine fluoride and glass ionomer in arresting dentine caries in preschool children
Zhi, Q. H., Lo, E. C. M., & Lin, H. (2012) · Journal of Dentistry · doi:10.1016/j.jdent.2012.08.002 · Cited by 270
Self-citation
Clinical Trials of Silver Diamine Fluoride in Arresting Caries among Children: A Systematic Review
Gao, S. S., Zhao, I. S., Hiraishi, N., Duangthip, D., Mei, M. L., Lo, E. C. M., & Chu, C. H. (2016) · JDR Clinical & Translational Research · doi:10.1177/2380084416661474 · Cited by 245
Self-citation

Show all 23 references

Research works printed but not linked: 3

Ainamo J, 1975, Int Dent J, 25, 229
Horst JA, 2016, J Calif Dent Assoc, 44, 16
Nelson T, 2016, Pediatr Dent, 38, 212

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Authors: Fung, M. H. T., Duangthip, D., Wong, M. C. M., Lo, E. C. M., & Chu, C. H.
Affiliations: University of Hong Kong (HK)
Corresponding author: Chu, C.H.
ORCID: Fung, M.H.T.
Duangthip, D.
Wong, M.C.M.
Lo, E.C.M.
Chu, C.H.
Venue: Journal of Dental Research
Publisher: SAGE Publications
Published: 2017-08-28
Volume: 97
Issue: 2
Pages: 171-178
ISSN: 0022-0345 (ISSN-L)
1544-0591
DOI: 10.1177/0022034517728496
PMC: PMC6429575
OpenAlex: W2750360976
Cited by: 249
References: 23
Citations by year: 2026: 14 · 2025: 33 · 2024: 49 · 2023: 31 · 2022: 31 · 2021: 28 · 2020: 32 · 2019: 15 · 2018: 15 · 2017: 1
FWCI: 23.77
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Dental Research (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Topics: Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
Health Sciences › Dentistry › Oral Surgery › Endodontics and Root Canal Treatments
Health Sciences › Dentistry › General Dentistry › Dental materials and restorations
Keywords: silver diamine fluoride, caries arrest, primary teeth, dentin caries, treatment frequency, visible plaque index, oral hygiene, children, pediatric dentistry, fluoride varnish, secondary caries, dental caries prevention, caries remineralization
MeSH terms: Quaternary Ammonium Compounds, Cariostatic Agents, Child, Preschool, Dental Caries, Female, Fluorides, Topical, Hong Kong, Humans, Male, Tooth, Deciduous, Treatment Outcome, Silver Compounds

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Randomized Clinical Trial of 12% and 38% Silver Diamine Fluoride Treatment

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