Role of Saliva and Salivary Diagnostics in the Advancement of Oral Health
Open accessAbstract
The objective of this article was to provide an account of some of the developments related to saliva over the first 100 years of the Journal of Dental Research and to outline some of the many biomarkers identified in saliva in the last few years. The first section covers findings in salivary physiology, biochemistry, calcium phosphate chemistry related to saliva, microbiology, and the role of saliva in maintaining oral health. The second section highlights salivary diagnostics, salivaomics, and saliva exosomics in the context of the emerging theme of personalized and precision medicine.
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Administration of anti-asthmatic medications at night without oral hygiene could increase the risk of alterations in the oral cavity.
“which could increase the risk of alterations at the level of the oral cavity [2,37,38,39].”
From Drugs Prescribed for Asthma and Their Adverse Effects on Dental Health (2023) · cites this paper as [38]
Anti-asthmatic medications are frequently administered at night before going to sleep without performing oral hygiene.
“In addition, anti-asthmatic medications are frequently administered at night before going to sleep without performing any routine method of oral hygiene”
From Drugs Prescribed for Asthma and Their Adverse Effects on Dental Health (2023) · cites this paper as [38]
Cites
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766 · see citing works
Experimental gingivitis in man
Löe, H., Theilade, E., & Jensen, S. B. (1965) · The Journal of Periodontology · doi:10.1902/jop.1965.36.3.177 · Cited by 3,481 · see citing works
Dewhirst, F. E., Chen, T., Izard, J., Paster, B. J., Tanner, A. C. R., Yu, W.-H., Lakshmanan, A., & Wade, W. G. (2010) · Journal of Bacteriology · doi:10.1128/jb.00542-10 · Cited by 3,352 · see citing works
The oral microbiome – an update for oral healthcare professionals
Kilian, M., Chapple, I. L. C., Hannig, M., Marsh, P. D., Meuric, V., Pedersen, A. M. L., Tonetti, M. S., Wade, W. G., & Zaura, E. (2016) · British Dental Journal · doi:10.1038/sj.bdj.2016.865 · Cited by 1,269 · see citing works
Detection and quantification of mutations in the plasma of patients with colorectal tumors
Diehl, F., Li, M., Dressman, D., He, Y., Shen, D., Szabo, S., Diaz, L. A., Goodman, S. N., David, K. A., Juhl, H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507904102 · Cited by 1,188 · see citing works
Sanz, M., Beighton, D., Curtis, M. A., Cury, J. A., Dige, I., Dommisch, H., Ellwood, R., Giacaman, R. A., Herrera, D., Herzberg, M. C., et al. (2017) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12682 · Cited by 390 · see citing works
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Drugs Prescribed for Asthma and Their Adverse Effects on Dental Health
Pacheco-Quito, E.-M., Jaramillo, J., Sarmiento-Ordoñez, J., & Cuenca-León, K. (2023) · Dentistry Journal · doi:10.3390/dj11050113 · Cited by 33 · see citing works
- Authors
- Dawes, C., & Wong, D. T. W.
- Affiliations
- University of Manitoba (CA)
- University of California, Los Angeles (US)
- Corresponding author
- Wong, D.T.W.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2019-01-22
- Volume
- 98
- Issue
- 2
- Pages
- 133-141
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- PMC
- PMC6900436
- OpenAlex
- W2913441481
- Cited by
- 218
- References
- 6
- Citations by year
- 2026: 30 · 2025: 24 · 2024: 37 · 2023: 38 · 2022: 25 · 2021: 33 · 2020: 23 · 2019: 7 · 2015: 1
- FWCI
- 15.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- GlaxoSmithKline (GSK/IADR Oral Health Innovation Award 2008 & 2011)
- National Institute of Health (R01 DE17170, R01 DE17593, R01 DE19255, R21 CA126733, U01 CA233370, U01 DE15018, U01 DE16275, U01 DE17593, U01 DE17790, UH2/UH3 CA206126, UH2/UH3 TR000923)
- Topics
- Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › HIV/AIDS oral health manifestations
- Keywords
- saliva, salivary diagnostics, salivaomics, salivary biomarkers, salivary physiology, salivary biochemistry, oral microbiology, oral health, personalized medicine, precision medicine
- MeSH terms
- Calcium Phosphates, Diagnosis, Oral, Humans, Oral Health, Periodicals as Topic, Saliva, Biomarkers, History, 20th Century, History, 21st Century, Precision Medicine
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