Transport of Sugars, Including Sucrose, by the msm Transport System of Streptococcus mutans
Abstract
The range of substrates transported by the sugar-binding protein-dependent msm (multiple sugar metabolism) system of S. mutans was investigated. By determining the ability of unlabeled sugar to compete with radiolabeled melibiose transport, we have demonstrated that the transported sugars included a number of carbohydrates structurally related to raffinose. A model accommodating these results has been devised which accounts for the sugars transported by the msm transport system. Competition with radiolabeled melibiose transport indicated sucrose to be an msm substrate. This was confirmed by examination of uptake of radiolabeled sucrose in scrAB mutants lacking the sucrose-specific phosphotransferase system.
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S mutans also transports oligosaccharides through ATP-binding cassette transporters, such as the multiple sugar metabolism and maltose transport complex systems.
“While readily metabolizable mono‐ and disaccharides are preferred, S mutans also transports oligosaccharides through ATP‐binding cassette transporters, such as the multiple sugar metabolism and maltose transport complex systems.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [289]
Cites
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Self-citationSucrose transport by Streptococcus mutans. Evidence for multiple transport systems
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The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755 · see citing works
Moye, Z. D., Zeng, L., & Burne, R. A. (2014) · Journal of Oral Microbiology · doi:10.3402/jom.v6.24878 · Cited by 164 · see citing works
“It was demonstrated that the primary PTS permease (EII) for trehalose (a-D-glucopyranosyl1,1-a-D-glucopyranoside) and the msm ABC transporter contributed modestly to growth on sucrose, so these systems appear to function in lower-affinity sucrose uptake, as suggested previously (14, 91).”
Background
- Authors
- Tao, L., Sutcliffe, I. C., Russell, R. R. B., & Ferretti, J. J.
- Affiliations
- University of Oklahoma Health Sciences Center (US)
- Newcastle University (GB)
- ORCID
- Sutcliffe, I.C.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 1993-10
- Volume
- 72
- Issue
- 10
- Pages
- 1386-1390
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2000861470
- Cited by
- 69
- References
- 14
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 3 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01de008191-10)
- National Institute of Dental and Craniofacial Research (DE 08191)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- Streptococcus mutans, sugar transport, sucrose transport, sugar-binding proteins, sugar uptake
- MeSH terms
- Biological Transport, Carbon Radioisotopes, Fructose, Glucans, Glucose, Isomaltose, Melibiose, Operon, Raffinose, Streptococcus mutans, Sucrose, Trehalose, Trisaccharides, Gene Expression Regulation, Bacterial, Carbohydrate Metabolism
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