Cited by 222Health disparities and outcomesDeath Anxiety and Social ExclusionStress Responses and Cortisol

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Social Isolation and Adult Mortality: The Role of Chronic Inflammation and Sex Differences

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Yang, Yang Claire, McClintock, Martha K., Kozloski, Michael, Li, Ting·2013·Journal of Health and Social Behavior

DOI 10.1177/0022146513485244PMC PMC3998519

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Abstract

The health and survival benefits of social embeddedness have been widely documented across social species, but the underlying biophysiological mechanisms have not been elucidated in the general population. We assessed the process by which social isolation increases the risk for all-cause and chronic disease mortality through proinflammatory mechanisms. Using the 18-year mortality follow-up data ( n = 6,729) from the National Health and Nutrition Examination Survey (1988–2006) on Social Network Index and multiple markers of chronic inflammation, we conducted survival analyses and found evidence that supports the mediation role of chronic inflammation in the link between social isolation and mortality. A high-risk fibrinogen level and cumulative inflammation burden may be particularly important in this link. There are notable sex differences in the mortality effects of social isolation in that they are greater for men and can be attributed in part to their heightened inflammatory responses.

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Authors: Yang, Y. C., McClintock, M. K., Kozloski, M., & Li, T.
Affiliations: University of North Carolina at Chapel Hill (US)
University of Chicago (US)
Corresponding author: Yang, Yang Claire
ORCID: Yang, Yang Claire
McClintock, Martha K.
Li, Ting
Venue: Journal of Health and Social Behavior
Publisher: SAGE Publications
Published: 2013-05-06
Volume: 54
Issue: 2
Pages: 183-203
ISSN: 0022-1465 (ISSN-L)
2150-6000
DOI: 10.1177/0022146513485244
PMC: PMC3998519
OpenAlex: W2151758923
Cited by: 222
References: 60
Citations by year: 2026: 16 · 2025: 24 · 2024: 14 · 2023: 27 · 2022: 19 · 2021: 31 · 2020: 16 · 2019: 9 · 2018: 23 · 2017: 11 · 2016: 7 · 2015: 11 · 2014: 11 · 2013: 3
FWCI: 12.14
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Health and Social Behavior (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (2r24hd050924-06)
National Institute on Aging (K01AG036745, R37AG030481, T32AG000243)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24 HD-050924)
Topics: Social Sciences › Health › Health disparities and outcomes
Social Sciences › Psychology › Social Psychology › Death Anxiety and Social Exclusion
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: social isolation, adult mortality, chronic inflammation, fibrinogen, social network index, mediation, sex differences, all-cause mortality, chronic disease mortality, social embeddedness
MeSH terms: Adult, Aged, Aged, 80 and over, Chronic Disease, Female, Humans, Inflammation, Male, Middle Aged, Mortality, Nutrition Surveys, Sex Characteristics, Social Isolation

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Social Isolation and Adult Mortality: The Role of Chronic Inflammation and Sex Differences

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