The DOI matches its Crossref record; 381 of the 382 references it cites were found in a registry or an index.
FELASA recommendations for the health monitoring of mouse, rat, hamster, guinea pig and rabbit colonies in breeding and experimental units
Open accessAbstract
The microbiological quality of experimental animals can critically influence animal welfare and the validity and reproducibility of research data. It is therefore important for breeding and experimental facilities to establish a laboratory animal health monitoring (HM) programme as an integrated part of any quality assurance system. FELASA has published recommendations for the HM of rodent and rabbit colonies in breeding and experimental units (Nicklas et al. Laboratory Animals, 2002), with the intention of harmonizing HM programmes. As stated in the preamble, these recommendations need to be adapted periodically to meet current developments in laboratory animal medicine. Accordingly, previous recommendations have been revised and shall be replaced by the present recommendations. These recommendations are aimed at all breeders and users of laboratory mice, rats, Syrian hamsters, guinea pigs and rabbits as well as diagnostic laboratories. They describe essential aspects of HM, such as the choice of agents, selection of animals and tissues for testing, frequency of sampling, commonly used test methods, interpretation of results and HM reporting. Compared with previous recommendations, more emphasis is put on the role of a person with sufficient understanding of the principles of HM, opportunistic agents, the use of sentinel animals (particularly under conditions of cage-level containment) and the interpretation and reporting of HM results. Relevant agents, testing frequencies and literature references are updated. Supplementary information on specific agents and the number of animals to be monitored and an example of a HM programme description is provided in the appendices.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The animals’ provenance, their health or immune status, and their history of previous testing or procedures can influence their physiology and behaviour, as well as their response to treatments, and thus impact on study outcomes.”
From Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 (2020) · cites this paper as [112]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The immune or microbiological status of the animals can also influence welfare, experimental variability, and scientific outcomes [112–114].”
From Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 (2020) · cites this paper as [112]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED: Histopathological Features of Capillaria hepatica Infection in Laboratory Rabbits
Mowat, V., Turton, J. A., Stewart, J., et al. (2009) · Toxicologic Pathology · doi:10.1177/0192623309339501 · Cited by 13
RetractedHow long do nosocomial pathogens persist on inanimate surfaces? A systematic review
Krämer, A., Schwebke, I., & Kampf, G. (2006) · BMC Infectious Diseases · doi:10.1186/1471-2334-6-130 · Cited by 2,508
A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease
Jonsson, C. B., Figueiredo, L. T. M., & Vapalahti, O. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00062-09 · Cited by 1,181
The Mouse in Biomedical Research
(1983) · Elsevier eBooks · doi:10.1016/c2013-0-10677-0 · Cited by 1,021
Weiss, S. R., & Leibowitz, J. L. (2011) · Advances in virus research · doi:10.1016/b978-0-12-385885-6.00009-2 · Cited by 926
Effects of Air Temperature and Relative Humidity on Coronavirus Survival on Surfaces
Casanova, L. M., Jeon, S., Rutala, W. A., Weber, D. J., & Sobsey, M. D. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.02291-09 · Cited by 736
Nicklas, W., Baneux, P. J. R., Boot, R., Decelle, T., Deeny, A., Fumanelli, M., & Illgen-Wilcke, B. (2002) · Laboratory Animals · doi:10.1258/0023677021911740 · Cited by 547
Self-citationCitrobacter rodentium of mice and man
Mundy, R., Macdonald, T., Dougan, G., Frankel, G., & Wiles, S. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00625.x · Cited by 545
Pathology of Laboratory Rodents and Rabbits
Percy, D. H., & Barthold, S. W. (2007) · Wiley eBooks · doi:10.1002/9780470344613 · Cited by 537
The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents
Suckow, M. A. (2012) · Elsevier eBooks · doi:10.1016/c2009-0-30495-x · Cited by 375
Research works printed but not linked: 19
- Nicklas W, 1993, Lab Anim Sci, 43, 296
- Koszdin KL, 2002, Contemp Top Lab Anim Sci, 41, 18
- Ike F, 2007, Comp Med, 57, 272
- Berard M, 2009, Comp Med, 59, 187
- Liang CT, 2009, J Am Assoc Lab Anim Sci, 48, 381
- Nicklas W, 1988, Lab Anim Sci, 38, 152
- Agca Y, 2007, Comp Med, 57, 51
- Lipman NS, 2000, Comp Med, 50, 426
- Labelle P, 2009, Comp Med, 59, 180
- ILAR. Committee on Long-Term Holding of Laboratory Rodents, 1976, ILAR News, 19, L1
- Dubin S, 1991, Lab Anim (NY), 20, 29
- Besselsen DG, 2000, Comp Med, 50, 498
- Janus LM, 2008, Comp Med, 58, 360
- Thomas ML, 2007, Comp Med, 57, 74
- Compton SR, 2004, Comp Med, 54, 382
- Smith PC, 2007, Comp Med, 57, 90
- Feinstein RE, 2011, Handbook of laboratory animal science, Vol. 1, Essential principles and practices, 613
- Boot R, 2001, Scand J Lab Anim Sci, 28, 2
- Besselsen DG, 2007, Comp Med, 57, 66
Cited by
Sorted by citations
Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0
Percie du Sert, N., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000411 · Cited by 2,677
The 3Rs and Humane Experimental Technique: Implementing Change
Hubrecht, R. C., & Carter, E. (2019) · Animals · doi:10.3390/ani9100754 · Cited by 687
“, [2]) and environmental variables are better controlled, so more emphasis is usually placed on achieving Reduction through good and appropriate experimental design.”
BackgroundReporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019Preprint
du Sert, N. P., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/703355 · Cited by 557
“The immune or microbiological status of the animals can also influence welfare, experimental variability and scientific outcomes [106-108].”
BackgroundSchaubeck, M., Clavel, T., Calasan, J., Lagkouvardos, I., Haange, S. B., Jehmlich, N., Basic, M., Dupont, A., Hornef, M., Bergen, M. V., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309333 · Cited by 447
Large-scale two-photon calcium imaging in freely moving mice
Zong, W., Obenhaus, H. A., Skytøen, E. R., Eneqvist, H., de Jong, N. L., do Vale, R. D., Jorge, M., Moser, M., & Moser, E. I. (2022) · Cell · doi:10.1016/j.cell.2022.02.017 · Cited by 344
Metadata
- Authors
- FELASA working group on revision of guidelines for health monitoring of rodents and rabbits, Mähler (Convenor), M., Berard, M., Feinstein, R., Gallagher, A., Illgen-Wilcke, B., Pritchett-Corning, K., & Raspa, M.
- Affiliations
- GV-SOLAS, Gesellschaft für Versuchstierkunde
- Swedish Veterinary Agency (SE)
- Medical Research Council (GB)
- University of Washington (US)
- AALAS, American Association for Laboratory Animal Science
- National Research Council (IT)
- Venue
- Laboratory Animals
- Publisher
- SAGE Publications
- Published
- 2014-02-04
- Volume
- 48
- Issue
- 3
- Pages
- 178-192
- ISSN
- 0023-6772 (ISSN-L)
- 1758-1117
- OpenAlex
- W2153218957
- Semantic Scholar
- 3f0f57dfc81bdbf0b4adc599d3696d57bd2535a2
- Cited by
- 646
- References
- 382
- Citations by year
- 2026: 36 · 2025: 63 · 2024: 69 · 2023: 60 · 2022: 67 · 2021: 73 · 2020: 62 · 2019: 62 · 2018: 47 · 2017: 42 · 2016: 28 · 2015: 24 · 2014: 12
- FWCI
- 51.91
- Type
- journal article
- Language
- en
- Update notices
- correction (2014-09-02)
- Open access
- bronze
- doi.org
- Locations
- Laboratory Animals (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Behavior and Welfare Studies
- Keywords
- laboratory animal health monitoring, sentinel animals, opportunistic pathogens, laboratory mice, laboratory rats, golden hamster, guinea pig, rabbits, laboratory animal medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
