Cited by 96Bariatric Surgery and OutcomesMinimally Invasive Surgical TechniquesDiabetes, Cardiovascular Risks, and Lipoproteins

Effect of laparoscopic Roux-en-Y gastric bypass on type 2 diabetes mellitus

Schauer, PR, Burguera, B, Ikramuddin, S, Cottam, D, Gourash, W, Hamad, G, Eid, GM, Mattar, S +5 more·2004·Nutrition in Clinical Practice

Abstract

Objective: To evaluate pre‐ and postoperative clinical parameters associated with improvement of diabetes up to 4 years after laparoscopic Roux‐en‐Y gastric bypass (LRYGBP) in patients with type 2 diabetes mellitus (T2DM). Summary background data: The surgical treatment of morbid obesity leads to dramatic improvement in the comorbidity status of most patients with T2DM. However, little is known concerning what preoperative clinical factors are associated with postoperative long‐term improvement in diabetes in the morbidly obese patient with diabetes. Methods: We evaluated pre‐ and postoperative data, including demographics, duration of diabetes, metabolic parameters, and clinical outcomes, in all patients with impaired fasting glucose (IFG) and type T2DM undergoing LRYGBP from July 1997 to May 2002. Results: During this 5‐year period, 1160 patients underwent LRYGBP, and 240 (21%) had IFG or T2DM. Follow‐up was possible in 191 of 240 patients (80%). There were 144 women (75%) with a mean preoperative age of 48 years (range, 26–67 years). After surgery, weight and body mass index decreased from 308 lbs and 50.1 kg/m2 to 211 lbs and 34 kg/m2 for a mean weight loss of 97 lbs and mean excess weight loss of 60%. Fasting plasma glucose and glycosylated hemoglobin concentrations returned to normal levels (83%) or markedly improved (17%) in all patients. A significant reduction in use of oral antidiabetic agents (80%) and insulin (79%) followed surgical treatment. Patients with the shortest duration (<5 years), the mildest form of T2DM (diet controlled), and the greatest weight loss after surgery were most likely to achieve complete resolution of T2DM. Conclusion: LRYGBP resulted in significant weight loss (60% percent of excess body weight loss) and resolution (83%) of T2DM. Patients with the shortest duration and mildest form of T2DM had a higher rate of T2DM resolution after surgery, suggesting that early surgical intervention is warranted to increase the likelihood of rendering patients euglycemic.

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Crossref · 10.1177/011542650401900160

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Authors
Schauer, P., Burguera, B., Ikramuddin, S., Cottam, D., Gourash, W., Hamad, G., Eid, G., Mattar, S., Ramanathan, R., Barinas‐Mitchel, E., Rao, R., Kuller, L., & Kelley, D.
Affiliations
University of Minnesota (US)
Venue
Nutrition in Clinical Practice
Publisher
Wiley
Published
2004-02
Volume
19
Issue
1
Pages
60-61
ISSN
  • 0884-5336 (ISSN-L)
  • 1941-2452
OpenAlex
W1973386775
Cited by
95
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 8 · 2019: 8 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 1 · 2014: 7 · 2013: 4 · 2012: 5
FWCI
0.65
Type
journal article
Language
en
Open access
closed
Locations
Nutrition in Clinical Practice (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Surgery › Minimally Invasive Surgical Techniques
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
laparoscopic Roux-en-Y gastric bypass, type 2 diabetes, morbid obesity, diabetes resolution, impaired fasting glucose, weight loss, excess weight loss, diabetes duration, oral antidiabetic drugs, insulin use, HbA1c, bariatric surgery

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