Aerobic Exercise in the Adjunctive Treatment of Depression: A Randomized Controlled Trial
Open accessAbstract
Two clinical trials have been conducted in a sample of depressed patients to determine whether the addition of an aerobic exercise programme to their usual treatment improved outcome after 12 weeks. In the first trial, an aerobic exercise group had a superior outcome compared with a control group in terms of trait anxiety and a standard psychiatric interview. A second trial was then conducted to compare an aerobic exercise programme with low intensity exercise. Both groups showed improvement but there were no significant differences between the groups. In neither trial was there any correlation between the extent of change in the subjects' physical fitness due to aerobic exercise and the extent of the improvement of psychiatric scores.
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Randomisation was adequately concealed in only three of the 14 included studies.
“randomisation was adequately concealed in only three studies”
The main outcome was measured by the participants themselves, by means of a questionnaire, in all but two of the studies.
“The main outcome was measured by the participants themselves, by means of a questionnaire, in all but two of the studies.73 75”
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References 13 · Cited by 123
- Authors
- Veale, D., Le Fevre, K., Pantelis, C., de Souza, V, Mann, A., & Sargeant, A.
- Affiliations
- The Royal Free Hospital (GB)
- Academic Department of Psychiatry, Royal Free Hospital School of Medicine, Pond Street, London NW3 2QG
- Vrije Universiteit Amsterdam (NL)
- ORCID
- Venue
- Journal of the Royal Society of Medicine
- Publisher
- SAGE Publications
- Published
- 1992-09
- Volume
- 85
- Issue
- 9
- Pages
- 541-544
- ISSN
- 0141-0768 (ISSN-L)
- 1758-1095
- PMC
- PMC1293641
- OpenAlex
- W1723211680
- Cited by
- 123
- References
- 13
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 8 · 2013: 7 · 2012: 3
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of the Royal Society of Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- aerobic exercise, depression, adjunctive therapy, exercise therapy, low-intensity exercise, trait anxiety, physical fitness, mental health outcomes
- MeSH terms
- Adult, Depressive Disorder, Exercise Therapy, Female, Humans, Male, Middle Aged, Oxygen Consumption, Psychiatric Status Rating Scales, Treatment Outcome
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