Enteral Glutamine Supplementation for Very‐Low‐Birth‐Weight Infants Decreases Hospital Costs
Abstract
Background: There is growing evidence that glutamine may be a conditionally essential amino acid for critically ill patients, including preterm infants cared for in neonatal intensive care units (NICUs). In a randomized study of 68 very‐low‐birth‐weight (VLBW) infants, we found evidence of lower morbidity in a group fed glutamine‐supplemented preterm infant formula from postnatal day 3 to day 30 than in a group fed a standard formula. We report here the effects of the glutamine supplementation on hospital costs in these infants. Methods: The costs were analyzed by log‐rank tests and Kaplan‐Meier plots. Results: The median costs for hospitalization, radiology, pharmacy, laboratory, and the NICU, and the median number of utilization units were reduced with glutamine supplementation. Conclusions: This study provides the first evidence for decreased hospital costs in VLBW neonates who receive enteral glutamine supplementation. (Journal of Parenteral and Enteral Nutrition 22:352–356, 1998)
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The REDOXS study generated concerns because randomization resulted in higher severity with more organ failures in the GLN groups, largely explaining the higher mortality.
“The REDOXS study (209), designed as a 2 x 2 factorial trial, generated concerns for a number of reasons, including the fact that the randomization resulted in higher severity with more organ failures in the GLN groups, largely explaining the higher mortality (234).”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [234]
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ESPEN guideline on clinical nutrition in the intensive care unit.
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Mechanick, J. I., Brett, E. M., Chausmer, A. B., Dickey, R. A., Wallach, S., Bergman, D. A., Garber, J. R., Hamilton, C. R., Handelsman, Y., Holdy, K. E., et al. (2003) · Endocrine Practice · doi:10.4158/ep.9.5.417 · Cited by 73 · see citing works
- Authors
- Dallas, M. J., Bowling, D., Roig, J. C., Auestad, N., & Neu, J.
- Affiliations
- University of Florida (US)
- Venue
- Journal of Parenteral and Enteral Nutrition
- Publisher
- Wiley
- Published
- 1998-11
- Volume
- 22
- Issue
- 6
- Pages
- 352-356
- ISSN
- 0148-6071 (ISSN-L)
- 1941-2444
- OpenAlex
- W2021394489
- Cited by
- 57
- References
- 0
- Citations by year
- 2026: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2016: 3 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Parenteral and Enteral Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (RR-00082, M01RR000082)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Keywords
- glutamine supplementation, very low birth weight infants, preterm infants, enteral nutrition, hospital costs, neonatal intensive care, preterm formula, health care utilization
- MeSH terms
- Birth Weight, Enteral Nutrition, Glutamine, Humans, Infant Food, Infant, Newborn, Length of Stay, Intensive Care, Neonatal, Hospital Costs, Infant, Very Low Birth Weight
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