The DOI matches its Crossref record; 184 of the 184 references it cites were found in a registry or an index.
Oxidative Stress and Oxidative Damage in Carcinogenesis
Open accessAbstract
Carcinogenesis is a multistep process involving mutation and the subsequent selective clonal expansion of the mutated cell. Chemical and physical agents including those that induce reative oxygen species can induce and/or modulate this multistep process. Several modes of action by which carcinogens induce cancer have been identified, including through production of reactive oxygen species (ROS). Oxidative damage to cellular macromolecules can arise through overproduction of ROS and faulty antioxidant and/or DNA repair mechanisms. In addition, ROS can stimulate signal transduction pathways and lead to activation of key transcription factors such as Nrf2 and NF-κB. The resultant altered gene expression patterns evoked by ROS contribute to the carcinogenesis process. Recent evidence demonstrates an association between a number of single nucleotide polymorphisms (SNPs) in oxidative DNA repair genes and antioxidant genes with human cancer susceptibility. These aspects of ROS biology will be discussed in the context of their relationship to carcinogenesis.
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Cited by
Kurutas, E. B. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0186-5 · Cited by 2,152
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases
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Oxidative Stress in Aging Human Skin
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Reactive oxygen species and cancer paradox: To promote or to suppress?
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Metadata
- Authors
- Klaunig, J. E., Kamendulis, L. M., & Hocevar, B. A.
- Venue
- Toxicologic Pathology
- Publisher
- SAGE Publications
- Published
- 2009-12-17
- Volume
- 38
- Issue
- 1
- Pages
- 96-109
- ISSN
- 0192-6233 (ISSN-L)
- 1533-1601
- OpenAlex
- W2123250752
- Cited by
- 957
- References
- 184
- FWCI
- 13.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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