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Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

Open access
Thoolen, Bob, Maronpot, Robert R., Harada, Takanori, Nyska, Abraham, Rousseaux, Colin, Nolte, Thomas, Malarkey, David E., Kaufmann, Wolfgang, Küttler, Karin, Deschl, Ulrich, Nakae, Dai, Gregson, Richard, Vinlove, Michael P., Brix, Amy E., Singh, Bhanu, Belpoggi, Fiorella, Ward, Jerrold M.·2010·Toxicologic Pathology

Abstract

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the hepatobiliary system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the hepatobiliary system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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Metadata

Authors
Thoolen, B., Maronpot, R. R., Harada, T., Nyska, A., Rousseaux, C., Nolte, T., Malarkey, D. E., Kaufmann, W., Küttler, K., Deschl, U., Nakae, D., Gregson, R., Vinlove, M. P., Brix, A. E., Singh, B., Belpoggi, F., & Ward, J. M.
Venue
Toxicologic Pathology
Published
2010-12
Volume
38
Issue
7_suppl
Pages
5S-81S
ISSN
  • 0192-6233 (ISSN-L)
  • 1533-1601
OpenAlex
W2101225650
Cited by
631
References
1
FWCI
6.67
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System. https://app.cochat.ai/papers/10.1177/0192623310386499
The paper
Thoolen, B., Maronpot, R. R., Harada, T., Nyska, A., Rousseaux, C., Nolte, T., Malarkey, D. E., Kaufmann, W., Küttler, K., Deschl, U., Nakae, D., Gregson, R., Vinlove, M. P., Brix, A. E., Singh, B., Belpoggi, F., & Ward, J. M. (2010). Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System. Toxicologic Pathology. https://doi.org/10.1177/0192623310386499

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.