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Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System
Open accessAbstract
The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the hepatobiliary system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the hepatobiliary system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.
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Cites
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Elmore, S. (2007) · Toxicologic Pathology · doi:10.1080/01926230701320337 · Cited by 13,853
Cited by
Wilkinson, J. E., Burmeister, L., Brooks, S. V., Chan, C., Friedline, S., Harrison, D. E., Hejtmancik, J. F., Nadon, N., Strong, R., Wood, L. K., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00832.x · Cited by 619
Immunohistochemistry for Pathologists: Protocols, Pitfalls, and Tips
Kim, S.-W., Roh, J., & Park, C.-S. (2016) · Journal of Pathology and Translational Medicine · doi:10.4132/jptm.2016.08.08 · Cited by 499
Mann, P. C., Vahle, J., Keenan, C. M., Baker, J. F., Bradley, A. E., Goodman, D. G., Harada, T., Herbert, R., Kaufmann, W., Kellner, R., et al. (2012) · Toxicologic Pathology · doi:10.1177/0192623312438738 · Cited by 241
Self-citationPathology of mouse models of accelerated aging
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Kent, L. N., Rakijas, J. B., Pandit, S. K., Westendorp, B., Chen, H.-Z., Huntington, J. T., Tang, X., Bae, S., Srivastava, A., Senapati, S., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85506 · Cited by 95
Metadata
- Authors
- Thoolen, B., Maronpot, R. R., Harada, T., Nyska, A., Rousseaux, C., Nolte, T., Malarkey, D. E., Kaufmann, W., Küttler, K., Deschl, U., Nakae, D., Gregson, R., Vinlove, M. P., Brix, A. E., Singh, B., Belpoggi, F., & Ward, J. M.
- Venue
- Toxicologic Pathology
- Publisher
- SAGE Publications
- Published
- 2010-12
- Volume
- 38
- Issue
- 7_suppl
- Pages
- 5S-81S
- ISSN
- 0192-6233 (ISSN-L)
- 1533-1601
- OpenAlex
- W2101225650
- Cited by
- 631
- References
- 1
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System. https://app.cochat.ai/papers/10.1177/0192623310386499
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- Thoolen, B., Maronpot, R. R., Harada, T., Nyska, A., Rousseaux, C., Nolte, T., Malarkey, D. E., Kaufmann, W., Küttler, K., Deschl, U., Nakae, D., Gregson, R., Vinlove, M. P., Brix, A. E., Singh, B., Belpoggi, F., & Ward, J. M. (2010). Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System. Toxicologic Pathology. https://doi.org/10.1177/0192623310386499
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.