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Rapamycin slows aging in mice
Abstract
Summary: Rapamycin increases lifespan in mice, but whether this represents merely inhibition of lethal neoplastic diseases, or an overall slowing in multiple aspects of aging is currently unclear. We report here that many forms of age‐dependent change, including alterations in heart, liver, adrenal glands, endometrium, and tendon, as well as age‐dependent decline in spontaneous activity, occur more slowly in rapamycin‐treated mice, suggesting strongly that rapamycin retards multiple aspects of aging in mice, in addition to any beneficial effects it may have on neoplastic disease. We also note, however, that mice treated with rapamycin starting at 9 months of age have significantly higher incidence of testicular degeneration and cataracts; harmful effects of this kind will guide further studies on timing, dosage, and tissue‐specific actions of rapamycin relevant to the development of clinically useful inhibitors of TOR action.
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Rapamycin delays multiple aspects of aging in mice.
“Notably, rapamycin delays multiple aspects of aging in mice (Wilkinson et al., 2012).”
From The Hallmarks of Aging (2013) · cites this paper as Wilkinson et al., 2012
Lifespan-extending doses of rapamycin in mice also promote the formation of cataracts, although cataracts have not been associated with rapalog treatment in humans.
“Finally, lifespan-extending doses of rapamycin in mice also promote the formation of cataracts 25, although cataracts have not been associated with rapalog treatment in humans.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [25]
Another side effect of doses of rapamycin that extend lifespan in mice is testicular degeneration, and reduced male fertility has been observed in humans treated with rapalogs.
“Another side effect of doses of rapamycin that extend lifespan in mice is testicular degeneration 25,144, and reduced male fertility has been observed in humans treated with rapalogs 145,146.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [25]
Inhibition of TOR activity has undesirable side-effects, such as impaired wound healing, insulin resistance, cataract and testicular degeneration in mice.
“it also has undesirable side-effects, such as impaired wound healing, insulin resistance, cataract and testicular degeneration in mice”
From The Hallmarks of Aging (2013) · cites this paper as Wilkinson et al., 2012
Rapamycin slows aging in a dose-dependent manner.
“When rapamycin is administered late in life, it extends lifespan (Harrison et al., 2009; Miller et al., 2011), slows aging in a dose-dependent manner, shows differential effects by sex (Wilkinson et al., 2012), and is synergistic with metformin.”
From Metformin as a tool to target aging (2016) · cites this paper as Wilkinson et al., 2012
Rapamycin shows differential effects by sex.
“When rapamycin is administered late in life, it extends lifespan (Harrison et al., 2009; Miller et al., 2011), slows aging in a dose-dependent manner, shows differential effects by sex (Wilkinson et al., 2012), and is synergistic with metformin.”
From Metformin as a tool to target aging (2016) · cites this paper as Wilkinson et al., 2012
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Metadata
- Authors
- Wilkinson, J. E., Burmeister, L., Brooks, S. V., Chan, C., Friedline, S., Harrison, D. E., Hejtmancik, J. F., Nadon, N., Strong, R., Wood, L. K., Woodward, M. A., & Miller, R. A.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2012-06-04
- Volume
- 11
- Issue
- 4
- Pages
- 675-682
- ISSN
- 1474-9718
- 1474-9726
- PMC
- PMC3434687
- Cited by
- 619
- References
- 5
- Language
- en
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