The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Olfactory Dysfunction and Sinonasal Symptomatology in COVID‐19: Prevalence, Severity, Timing, and Associated Characteristics
Open accessAbstract
Objective: Olfactory dysfunction (OD)—hyposmia or anosmia—is a symptom of coronavirus disease 2019 (COVID‐19), caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). We sought to better determine prevalence, severity, and timing of OD in COVID‐19 relative to other sinonasal and pulmonary symptoms. Study Design: Prospective, cross‐sectional. Setting: Regional/cantonal hospital. Subjects: In total, 103 patients diagnosed with COVID‐19 with reverse transcription polymerase chain reaction (RT‐PCR)–based testing. Methods: All patients testing positive for COVID‐19 at Kantonsspital Aarau over a 6‐week period were approached. Timing and severity (at its worst, on scale of 0 [none], 1 [mild], 2 [moderate], and 3 [severe]) of OD, loss of taste, nasal obstruction, rhinorrhea/mucus production, fever, cough and shortness of breath (SOB) were assessed for each patient. Results: Prevalence of OD was 61.2%, and severity of OD was strongly correlated with severity of loss of taste experienced (ρ = 0.87, P <. 001). OD was experienced on the first day of COVID‐19 by 8.7% and overall occurred at median infection day 3 (mean, 3.4; range, 0‐12). Most experiencing OD reported anosmia, and mean severity of all with OD was moderate to severe (mean [SD], 2.7 [0.6]). Nasal obstruction (49.5%) and rhinorrhea (35.0%) were frequently reported but not correlated with OD. SOB was more severe in patients with OD. OD was associated negatively with older age (OR, 0.96; 95% CI, 0.93‐0.99; P =. 007) and positively with female sex (OR, 2.46; 95% CI, 0.98‐6.19; P =. 056). Conclusions: OD is highly prevalent during COVID‐19, occurring early and severely, often in conjunction with loss of taste. OD is associated negatively with older age and positively with female sex. Patients with OD may also experience more severe SOB.
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Clinical characteristics of coronavirus disease 2019 in China
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Organ-specific manifestations of COVID-19 infection
Gavriatopoulou, M., Korompoki, E., Fotiou, D., Ntanasis-Stathopoulos, I., Psaltopoulou, T., Kastritis, E., Terpos, E., & Dimopoulos, M. A. (2020) · Clinical and Experimental Medicine · doi:10.1007/s10238-020-00648-x · Cited by 502
Mood, Anxiety and Olfactory Dysfunction in COVID‐19: Evidence of Central Nervous System Involvement?
Speth, M. M., Singer‐Cornelius, T., Oberle, M., Gengler, I., Brockmeier, S. J., & Sedaghat, A. R. (2020) · The Laryngoscope · doi:10.1002/lary.28964 · Cited by 106
“The severity of OD occurring in these participants was associated with younger age and female gender, and also tended to correlate with more severe symptoms of COVID-19, such as shortness of breath.(19) Chemosensory dysfunction, outside of the context of COVID-19, has been previously shown to be associated with decrea…”
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Metadata
- Authors
- Speth, M. M., Singer‐Cornelius, T., Oberle, M., Gengler, I., Brockmeier, S. J., & Sedaghat, A. R.
- Venue
- Otolaryngology–Head and Neck Surgery
- Publisher
- Wiley
- Published
- 2020-05-19
- Volume
- 163
- Issue
- 1
- Pages
- 114-120
- ISSN
- 0161-6439 (ISSN-L)
- 0194-5998
- 1097-6817
- OpenAlex
- W3025216333
- Cited by
- 253
- References
- 30
- FWCI
- 18.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Speth, M. M., Singer‐Cornelius, T., Oberle, M., Gengler, I., Brockmeier, S. J., & Sedaghat, A. R. (2020). Olfactory Dysfunction and Sinonasal Symptomatology in COVID‐19: Prevalence, Severity, Timing, and Associated Characteristics. Otolaryngology–Head and Neck Surgery. https://doi.org/10.1177/0194599820929185
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