The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Role of terminal warm blood cardioplegia in complex congenital heart surgery
Abstract
Introduction Myocardial protection is vital to ensure successful open heart surgery. Cardioplegic solution is one method to achieve good myocardial protection. Inevitably, ischemia-reperfusion injury occurs with aortic crossclamping. Histidine-tryptophan-ketoglutarate solution is a frequently used cardioplegia for complex congenital heart surgery. We postulated that addition of terminal warm blood cardioplegia before removal of the aortic crossclamp might improve myocardial protection. Method A randomized controlled trial was conducted on 109 cyanotic patients aged, 1 to 5 years who underwent complex biventricular repair. They were divided into a control group of 55 patients who had histidine-tryptophan-ketoglutarate only and a treatment group of 54 who had histidine-tryptophan-ketoglutarate with terminal warm blood cardioplegia. Endpoints were clinical parameters, troponin I levels, and caspase-3 as an apoptosis marker. Results The incidence of low cardiac output syndrome was 34%, with no significant difference between groups (35.2% vs. 33.3%, p = 0.84). The incidence of arrhythmias in our treatment group was lower compared to the control group (36% vs. 12%, p = 0.005). Troponin I and caspase-3 results did not show any significant differences between groups. For cases with Aristotle score ≥ 10, weak expression of caspase-3 in the treatment group post-cardiopulmonary bypass was lower compared to the control group. Conclusion For complex congenital cardiac surgery, the addition of terminal warm blood cardioplegia does not significantly improve postoperative clinical or metabolic markers.
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“In the pediatric population reported incidences are between 17 and 67% (9–11).”
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Cites
Role of apoptosis in reperfusion injury.
Eefting, F., Rensing, B., Wigman, J., Pannekoek, W., Liu, W.-M., Cramer, M., Lips, D., & Doevendans, P. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.12.023 · Cited by 439
Sanada, S., Komuro, I., & Kitakaze, M. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00553.2011 · Cited by 394
(2006) · Circulation · doi:10.1161/circ.114.4.257 · Cited by 364
The Aristotle score for congenital heart surgery
Lacour-Gayet, F. G., Clarke, D., Jacobs, J. P., Gaynor, J. W., Hamilton, L., Jacobs, M. L., Maruszewski, B. J., Pozzi, M., Spray, T. L., Tchervenkov, C. I., et al. (2004) · Seminars in Thoracic and Cardiovascular Surgery Pediatric Cardiac Surgery Annual · doi:10.1053/j.pcsu.2004.02.011 · Cited by 171
Black, S. C., Huang, J., Rezaiefar, P., Radinovic, S., Eberhart, A., Nicholson, D. W., & Rodger, I. W. (1998) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1998.0660 · Cited by 152
Kotani, Y., Tweddell, J. S., Gruber, P. J., Pizarro, C., Austin, E. H., Woods, R. K., Gruenwald, C. E., & Caldarone, C. A. (2013) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2013.05.052 · Cited by 106
Causes of death after congenital heart surgery.
Ma, M., Gauvreau, K., Allan, C. K., Mayer, J., & Jenkins, K. (2007) · Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.10.073 · Cited by 89
Pouard, P., Mauriat, P., Ek, F., Haydar, A., Gioanni, S., Laquay, N., Vaccaroni, L., & Vouhé, P. R. (2006) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2006.07.032 · Cited by 78
Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease
K. Chandler, H., & Kirsch, R. (2016) · Current Cardiology Reviews · doi:10.2174/1573403x12666151119164647 · Cited by 74 · cited 1×
“The overall incidence of LCOS was 34%, this is higher than in previous studies (approximately 25% at 6–18 h postoperatively).(19) This is because the patients in this study were more complex compared to those in previous reports.”
ResultLiu, J., Feng, Z., Zhao, J., Li, B., & Long, C. (2008) · ASAIO Journal · doi:10.1097/mat.0b013e318188b86c · Cited by 65
Research works printed but not linked: 1
- Habertheuer A, 2014, Biomed Res Int 2014, 2014, 325725
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Schoonen, A., van Klei, W. A., van Wolfswinkel, L., & van Loon, K. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.926957 · Cited by 74
Zhou, K., Li, D., Zhang, X., Wang, W., Li, S., & Song, G. (2021) · Congenital Heart Disease · doi:10.32604/chd.2021.016396 · Cited by 3
Şener, E. F., Hamurcu, Z., Taheri, S., Tahtasakal, R., Delibaşı, N., Elçik, D., Mehmetbeyoğlu, E., Tunçay, A., Dal, F., Bayram, K. K., et al. (2023) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20220479 · Cited by 2
Myocardial Protection in Children
Doğan, A., & Türköz, R. (2020) · Springer eBooks · doi:10.1007/978-3-030-24174-2_87 · Cited by 2
Enhancement of myocardial recovery with terminal ‘hot shot’ cardioplegia
Khilji, S. A., & Ghaffar, M. F. (2024) · Journal of Shalamar Medical & Dental College - JSHMDC · doi:10.53685/jshmdc.v5i2.229
Is Hot-shot Cardioplegia Necessary in Cardiac Surgery with Cardiopulmonary Bypass?
Amaç, B., Engin, M., & Abanoz, M. (2025) · Archives of Current Medical Research · doi:10.47482/acmr.1631396
Metadata
- Authors
- Busro, P. W., Romolo, H., Sastroasmoro, S., Rachmat, J., Sadikin, M., Santoso, A., Boom, C. E., Suwarto, S., & Jusuf, A. A.
- Affiliations
- Pembuluh Darah Harapan Kita (ID)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
- University of Indonesia (ID)
- Corresponding author
- Busro, Pribadi Wiranda
- ORCID
- Venue
- Asian Cardiovascular and Thoracic Annals
- Publisher
- SAGE Publications
- Published
- 2018-02-15
- Volume
- 26
- Issue
- 3
- Pages
- 196-202
- ISSN
- 0218-4923 (ISSN-L)
- 1816-5370
- OpenAlex
- W2789672860
- Cited by
- 6
- References
- 21
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Asian Cardiovascular and Thoracic Annals (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- histidine-tryptophan-ketoglutarate, cardioprotection, congenital heart surgery, cyanotic congenital heart disease, biventricular repair, aortic cross-clamping, ischemia-reperfusion injury, low cardiac output syndrome, postoperative arrhythmia, troponin I, caspase-3, apoptosis
- MeSH terms
- Arrhythmias, Cardiac, Cardiac Output, Low, Cardioplegic Solutions, Child, Preschool, Female, Glucose, Heart Arrest, Induced, Heart Defects, Congenital, Humans, Indonesia, Infant, Male, Mannitol, Myocardium, Potassium Chloride, Procaine, Temperature, Time Factors, Biomarkers, Treatment Outcome, Apoptosis, Troponin I, Caspase 3
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