E3 ubiquitin ligases and human papillomavirus-induced carcinogenesis

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Incidence Trends for Human Papillomavirus–Related and –Unrelated Oral Squamous Cell Carcinomas in the United States

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Distinct Risk Factor Profiles for Human Papillomavirus Type 16–Positive and Human Papillomavirus Type 16–Negative Head and Neck Cancers

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Connections with Connexins: the Molecular Basis of Direct Intercellular Signaling

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Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

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Ubiquitin signalling in the NF-κB pathway

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New insights into TGF-β–Smad signalling

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Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

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The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

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Gap junctions and the connexin protein family

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Comparison of In Vitro Anticancer-Drug-Screening Data Generated With a Tetrazolium Assay Versus a Protein Assay Against a Diverse Panel of Human Tumor Cell Lines

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E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.

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Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2

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Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors

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Insulin-like Growth Factor (IGF)-binding Protein-3 Induces Apoptosis and Mediates the Effects of Transforming Growth Factor-β1 on Programmed Cell Death through a p53- and IGF-independent Mechanism

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Drug discovery in the ubiquitin–proteasome system

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Cloning and Expression of the cDNA for E6-AP, a Protein that Mediates the Interaction of the Human Papillomavirus E6 Oncoprotein with p53

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The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture

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Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC)

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Human Scribble (Vartul) Is Targeted for Ubiquitin-Mediated Degradation by the High-Risk Papillomavirus E6 Proteins and the E6AP Ubiquitin-Protein Ligase

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Papillomavirus Type 16 Oncogenes Downregulate Expression of Interferon-Responsive Genes and Upregulate Proliferation-Associated and NF-κB-Responsive Genes in Cervical Keratinocytes

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Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins

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Human Papillomavirus Type 16 E7 Oncoprotein Associates with the Cullin 2 Ubiquitin Ligase Complex, Which Contributes to Degradation of the Retinoblastoma Tumor Suppressor

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Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT Domain E3 Ligase

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Destabilization of the RB Tumor Suppressor Protein and Stabilization of p53 Contribute to HPV Type 16 E7-Induced Apoptosis

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The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein–ubiquitin ligase SCFSkp2Preprint

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MDM2 Is a Negative Regulator of p21 , Independent of p53

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Regulation of TGF‐β family signaling by E3 ubiquitin ligases

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Clinician's guide to human papillomavirus immunology: knowns and unknowns

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Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway

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Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types.

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The E5 gene from human papillomavirus type 16 is an oncogene which enhances growth factor-mediated signal transduction to the nucleus.

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Deubiquitinating enzymes--the importance of driving in reverse along the ubiquitin-proteasome pathway.

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SCF-mediated protein degradation and cell cycle control

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The role of human papillomavirus infection in head and neck cancers

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E3-Ubiquitin Ligase/E6-AP Links Multicopy Maintenance Protein 7 to the Ubiquitination Pathway by a Novel Motif, the L2G Box

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The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradation

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Characterization of Human hect Domain Family Members and Their Interaction with UbcH5 and UbcH7

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Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue

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Human papillomavirus-induced carcinogenesis and the ubiquitin–proteasome system

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Extended follow‐up of a phase II trial in relapsed, refractory multiple myeloma:

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The Human Papillomavirus Type 16 E5 Gene Cooperates with the E7 Gene to Stimulate Proliferation of Primary Cells and Increases Viral Gene Expression

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The loss of mdm2 induces p53 mediated apoptosis

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Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process

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Differential expression and activation of NF‐κB family proteins during oral carcinogenesis: Role of high risk human papillomavirus infection

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The E5 Gene of HPV-16 Enhances Keratinocyte Immortalization by Full-Length DNA

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Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs

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Reduced levels of connexin43 in cervical dysplasia: inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression.

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Degradation of Tyrosine Phosphatase PTPN3 (PTPH1) by Association with Oncogenic HumanPapillomavirus E6 Proteins

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HPV16 E5 protein disrupts the c-Cbl–EGFR interaction and EGFR ubiquitination in human foreskin keratinocytes

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EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer

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The Human Papilloma Virus E7 Oncoprotein Inhibits Transforming Growth Factor-β Signaling by Blocking Binding of the Smad Complex to Its Target Sequence

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Human Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3

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p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma

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The DNA repair protein, O6-Methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein

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Human papillomavirus type 16 E6 and E7 oncoproteins upregulate c-IAP2 gene expression and confer resistance to apoptosis

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The Papillomavirus E7 Oncoprotein Is Ubiquitinated by UbcH7 and Cullin 1- and Skp2-Containing E3 Ligase

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Insulin-like growth factor 1 is a potent stimulator of cervical cancer cell invasiveness and proliferation that is modulated by α v β 3 integrin signaling

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High-Risk But Not Low-Risk HPV E2 Proteins Bind to the APC Activators Cdh1 and Cdc20 and Cause Genomic Instability

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SOC1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein

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Human Papillomavirus Type 18 E6 Protein Binds the Cellular PDZ Protein TIP-2/GIPC, Which Is Involved in Transforming Growth Factor β Signaling and Triggers Its Degradation by the Proteasome

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NFX1 Interacts with mSin3A/Histone Deacetylase To Repress hTERT Transcription in Keratinocytes

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Human papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase.

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Regulation of the Human Papillomavirus Type 18 E6/E6AP Ubiquitin Ligase Complex by the HECT Domain-Containing Protein EDD

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Ubiquitin branches out

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An Essential Role of Human Ada3 in p53 Acetylation

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The Role of the Ubiquitin Ligase E6-AP in Human Papillomavirus E6-mediated Degradation of PDZ Domain-containing Proteins

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USP11 Stabilizes HPV-16E7 and Further Modulates the E7 Biological Activity

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Degradation of hDlg and MAGIs by human papillomavirus E6 is E6-AP-independent

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Stability of the Human Papillomavirus Type 18 E2 Protein Is Regulated by a Proteasome Degradation Pathway through Its Amino-Terminal Transactivation Domain

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Toll-Like Receptors in Human Papillomavirus Infection

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Human Papilloma Virus (HPV) and Host Cellular Interactions

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Human Papillomavirus Seropositivity Synergizes withMDM2Variants to Increase the Risk of Oral Squamous Cell Carcinoma

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Identification of annexin A1 as a novel substrate for E6AP‐mediated ubiquitylation

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p53 and MDM2 Expression in Oral Squamous Cell Carcinoma

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Differential Production of Cytokines and Activation of NF-κB in HPV-Transformed Keratinocytes

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Cellular Steady-State Levels of “High Risk” but Not “Low Risk” Human Papillomavirus (HPV) E6 Proteins Are Increased by Inhibition of Proteasome-Dependent Degradation Independent of Their p53- and E6AP-Binding Capabilities

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Expression of p53, MDM2, p21, heat shock protein 70, and HPV 16/18 E6 proteins in oral verrucous carcinoma and oral verrucous hyperplasia

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The Human Papillomavirus Type 18 E2 Protein Is a Cell Cycle-Dependent Target of the SCF Skp2 Ubiquitin Ligase

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Connexin 43 expression is downregulated in raft cultures of human keratinocytes expressing the human papillomavirus type 16 E5 protein

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Decreased Expression of Annexin A1 during the Progression of Cervical Neoplasia

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