The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Role of viral infection in sudden hearing loss
Open accessAbstract
According to a recent epidemiological survey, the incidence of sudden sensorineural hearing loss (SSNHL) is increasing yearly. The cause of SSNHL is of great interest in research. To date, viral infection, vascular occlusion, abnormal cellular stress responses within the cochlea, and immune-mediated mechanisms are considered the most likely etiologies of this disease. Among these etiologies, the relationship between viral infection and sudden deafness has been unclear. In this review, we mainly discuss the viral hypothesis of SSNHL. There is little research proving or clearly indicating the pathogenesis of this disease. Further research is needed to elucidate the precise etiopathogenesis to better understand SSNHL and establish more suitable treatment to help restore hearing in affected patients.
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“Although some hypotheses have been proposed regarding the causes of SSNHL, such as vascular insufficiency, 22 virus infection, 28 and immune dysfunction, 29 none of these can explain SSNHL in all patients.”
From Recurrent sudden sensorineural hearing loss—A literature review (2022) · cites this paper as [28]
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“Acute respiratory tract infections (RTIs), which include both upper and lower respiratory tract illnesses, are among the most common infectious diseases worldwide and are predominantly viral in origin. Pathogens such as influenza, respiratory syncytial virus (RSV), rhinovirus, and coronaviruses are frequent culprits [6].”
From Acute Respiratory Tract Infection and Sudden Sensorineural Hearing Loss: A Multinational Cohort Study (2025) · cites this paper as [6]
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Citations
Cites
Clinical Practice Guideline: Sudden Hearing Loss
Stachler, R. J., Chandrasekhar, S. S., Archer, S. M., Rosenfeld, R. M., Schwartz, S. R., Barrs, D. M., Brown, S. R., Fife, T. D., Ford, P., Ganiats, T. G., et al. (2012) · Otolaryngology–Head and Neck Surgery · doi:10.1177/0194599812436449 · Cited by 971
Viral Causes of Hearing Loss: A Review for Hearing Health Professionals
Cohen, B. E., Durstenfeld, A., & Roehm, P. C. (2014) · Trends in Hearing · doi:10.1177/2331216514541361 · Cited by 474
Pathology and Pathophysiology of Idiopathic Sudden Sensorineural Hearing Loss
Merchant, S. N., Adams, J. C., & Nadol, J. B. (2005) · Otology & Neurotology · doi:10.1097/00129492-200503000-00004 · Cited by 274
Treatment of Sudden Sensorineural Hearing Loss
Conlin, A. E., & Parnes, L. S. (2007) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.133.6.573 · Cited by 259
Theory of Membrane Breaks in Sudden Hearing Loss
Simmons, F. B. (1968) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.1968.00770010043009 · Cited by 229
Yun, N. E., & Walker, D. H. (2012) · Viruses · doi:10.3390/v4102031 · Cited by 224
Merchant, S. N., Durand, M. L., & Adams, J. C. (2008) · ORL · doi:10.1159/000111048 · Cited by 182
Idiopathic sudden sensorineural hearing loss.
Mattox, D. E., & Lyles, C. A. (1989) · PubMed · Cited by 169
Diagnosis and Treatment of Sudden‐Onset Sensorineural Hearing Loss: A Study of 51 Patients
Zadeh, M. H., Storper, I. S., & Spitzer, J. B. (2003) · Otolaryngology · doi:10.1067/mhn.2003.50 · Cited by 168
LXXIII Sudden Perceptive Deafness and Viral Infection
van Dishoeck, H. A. E., & Bierman, T. A. (1957) · Annals of Otology Rhinology & Laryngology · doi:10.1177/000348945706600406 · Cited by 147
Research works printed but not linked: 2
- Morrison A, Booth JB. Sudden deafness: an otological emergency. Br J Hosp Med 1970; 4: 287–298.
- Wright KE. Mumps. In: Newton VE, Valley PJ (eds). Infection and hearing impairment. Chichester, England: John Wiley, 2006, pp.109–126.
Cited by
Sorted by citations
Sudden irreversible hearing loss post COVID-19
Koumpa, F. S., Forde, C. T., & Manjaly, J. (2020) · BMJ Case Reports · doi:10.1136/bcr-2020-238419 · Cited by 224
Jeong, M., Ocwieja, K. E., Han, D., Wackym, P. A., Zhang, Y., Brown, A., Moncada-Reid, C., Vambutas, A., Kanne, T. J., Crain, R., et al. (2021) · Communications Medicine · doi:10.1038/s43856-021-00044-w · Cited by 116
Update on Findings about Sudden Sensorineural Hearing Loss and Insight into Its Pathogenesis
Yamada, S., Kita, J., Shinmura, D., Nakamura, Y., Sahara, S., Misawa, K., & Nakanishi, H. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216387 · Cited by 72
Salepci, E., Türk, B., Ozcan, S. N., Bektaş, M. E., Aybal, A., Dökmetaş, İ., & Turgut, S. (2020) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-020-06284-1 · Cited by 64
Cardiovascular Risk and Sudden Sensorineural Hearing Loss: A Systematic Review and Meta‐Analysis
Simões, J., Vlaminck, S., Seiça, R. M. F., Acke, F. R. E., & Miguéis, A. (2022) · The Laryngoscope · doi:10.1002/lary.30141 · Cited by 64
Metadata
- Authors
- Chen, X., Fu, Y.-Y., & Zhang, T.-Y.
- Affiliations
- Shanghai Medical College of Fudan University (CN)
- ENT institute, Eye & ENT Hospital of Fudan University, Shanghai, China
- ENT institute, Eye & ENT Hospital of Fudan University, Shanghai, China; Hearing Medicine Key Laboratory, National Health and Family Planning Commission, Shanghai, China
- ORCID
- Chen, Xin
- Venue
- Journal of International Medical Research
- Publisher
- SAGE Publications
- Published
- 2019-05-27
- Volume
- 47
- Issue
- 7
- Pages
- 2865-2872
- ISSN
- 0300-0605 (ISSN-L)
- 1473-2300
- PMC
- PMC6683896
- OpenAlex
- W2947966724
- Cited by
- 136
- References
- 52
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 22 · 2023: 25 · 2022: 34 · 2021: 17 · 2020: 11 · 2019: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of International Medical Research (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Health Sciences › Health Professions › Speech and Hearing › Hearing Loss and Rehabilitation
- Keywords
- sudden sensorineural hearing loss, viral infection, viral hypothesis, etiopathogenesis, immune-mediated mechanisms, vascular occlusion, cellular stress response, hearing loss treatment
- MeSH terms
- Hearing Loss, Sudden, Humans, Prognosis, Risk Factors, Virus Diseases, Viruses
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