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Evaluation of monocyte-to-high-density lipoprotein cholesterol ratio and monocyte-to-lymphocyte ratio in ischemic stroke
Open accessAbstract
Objectives: We aimed to evaluate the diagnostic value of the combination of the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) with the monocyte-to-lymphocyte ratio (MLR) in ischemic stroke patients. Methods: There were 253 patients who were diagnosed with ischemic stroke and 211 healthy subjects enrolled into this retrospective study. Result: MHR and MLR were significantly higher in ischemic stroke patients compared with controls. MHR and MLR remained as independent variables for the presence of ischemic stroke. In receiver operating characteristic analyses, the optimal cut-off values for MHR and MLR were 0.28 and 0.19, respectively. The area under the curve for MHR was 0.777 (sensitivity, 66.01%; specificity, 77.25%), and that for MLR was 0.742 (sensitivity, 70.36%; specificity, 67.77%) in ischemic stroke patients. Moreover, the combination MHR and MLR increased the sensitivity compared with MHR or MLR alone. Conclusion: The present study shows that a high MHR and MLR are each predictive for the risk of ischemic stroke, and together, they exhibit a better diagnostic value compared with each ratio alone.
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“The SII, SIRI, MHR, NHR, LHR, and PHR are considered cost-effective and simple laboratory parameters indicating systemic inflammation in many diseases (18, 19, 21–23, 26, 27, 30–34).”
From Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder (2022) · cites this paper as [32]
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Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients
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Wei, Y., Wang, T., Li, G., Feng, J., Deng, L., Xu, H., Yin, L., Ma, J., Chen, D., & Chen, J. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.941728 · Cited by 99
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Metadata
- Authors
- Liu, H., Zhan, F., & Wang, Y.
- Affiliations
- Soochow University (CN)
- Department of Clinical Laboratory, Changzhou Tumor Hospital Affiliated with Soochow University, Jiangsu, China
- Corresponding author
- Liu, Huiling
- Venue
- Journal of International Medical Research
- Publisher
- SAGE Publications
- Published
- 2020-07
- Volume
- 48
- Issue
- 7
- Pages
- 300060520933806-300060520933806
- ISSN
- 0300-0605 (ISSN-L)
- 1473-2300
- PMC
- PMC7361497
- OpenAlex
- W3043176161
- Cited by
- 31
- References
- 1
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 2 · 2023: 8 · 2022: 7 · 2021: 6
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of International Medical Research (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- ischemic stroke, monocyte-to-lymphocyte ratio, inflammatory markers, diagnostic accuracy, cut-off values, combined biomarker prediction
- MeSH terms
- Ischemic Stroke, Brain Ischemia, Humans, Cholesterol, HDL, Lymphocytes, Monocytes, Retrospective Studies, Stroke
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