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Double-Blind Report on the Efficacy of Lactic Acid-Producing Enterococcus SF68 in the Prevention of Antibiotic-Associated Diarrhoea and in the Treatment of Acute Diarrhoea
Abstract
A multicentre double-blind, placebo-controlled clinical trial, involving 123 patients at 10 centres, was carried out to assess the efficacy of a preparation of lactic acid-producing Enterococcus SF 68 in the prevention of antibiotic-associated diarrhoea and in the treatment of acute diarrhoea. In the prevention study, 45 patients being treated with antibiotics were given, concurrently, one capsule twice daily of either Enterococcus SF68 or placebo. Acute diarrhoea was present in 78 patients who were given the same treatment but three times daily. All treatments were continued for 7 days. Enterococcus SF 68 was shown to be effective in reducing the incidence of antibiotic-associated diarrhoea in comparison with placebo (8.7% compared with 27.2%, respectively). Patients with acute enteritis showed a significantly faster resolution of bowel abnormalities during treatment with Enterococcus SF68 compared with placebo.
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Citations
Cited by
McFarland, L. V. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00465.x · Cited by 872
Newberry, S. J. (2012) · JAMA · doi:10.1001/jama.2012.3507 · Cited by 870
Enterococci as probiotics and their implications in food safety
Franz, C. M. A. P., Huch, M., Abriouel, H., Holzapfel, W., & Gálvez, A. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.08.014 · Cited by 788
Sazawal, S., Hiremath, G., Dhingra, U., Malik, P., Deb, S., & Black, R. E. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70495-9 · Cited by 561
Probiotics for treating acute infectious diarrhoea
Allen, S. J., Martinez, E. G., Gregorio, G. V., & Dans, L. F. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003048.pub3 · Cited by 628
Metadata
- Authors
- Wunderlich, P. F., Braun, L., Fumagalli, I., D'Apuzzo, V., Heim, F., Karly, M., Lodi, R., Politta, G., Vonbank, F., & Zeltner, L.
- Venue
- Journal of International Medical Research
- Publisher
- SAGE Publications
- Published
- 1989-07
- Volume
- 17
- Issue
- 4
- Pages
- 333-338
- ISSN
- 0300-0605 (ISSN-L)
- 1473-2300
- OpenAlex
- W2152231693
- Cited by
- 177
- References
- 0
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Double-Blind Report on the Efficacy of Lactic Acid-Producing Enterococcus SF68 in the Prevention of Antibiotic-Associated Diarrhoea and in the Treatment of Acute Diarrhoea. https://app.cochat.ai/papers/10.1177/030006058901700405
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- Wunderlich, P. F., Braun, L., Fumagalli, I., D'Apuzzo, V., Heim, F., Karly, M., Lodi, R., Politta, G., Vonbank, F., & Zeltner, L. (1989). Double-Blind Report on the Efficacy of Lactic Acid-Producing Enterococcus SF68 in the Prevention of Antibiotic-Associated Diarrhoea and in the Treatment of Acute Diarrhoea. Journal of International Medical Research. https://doi.org/10.1177/030006058901700405
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
