Probiotics for the Prevention and Treatment of Antibiotic-Associated Diarrhea: A Systematic Review and Meta-analysis
Abstract
CONTEXT: Probiotics are live microorganisms intended to confer a health benefit when consumed. One condition for which probiotics have been advocated is the diarrhea that is a common adverse effect of antibiotic use. OBJECTIVE: To evaluate the evidence for probiotic use in the prevention and treatment of antibiotic-associated diarrhea (AAD). DATA SOURCES: Twelve electronic databases were searched (DARE, Cochrane Library of Systematic Reviews, CENTRAL, PubMed, EMBASE, CINAHL, AMED, MANTIS, TOXLINE, ToxFILE, NTIS, and AGRICOLA) and references of included studies and reviews were screened from database inception to February 2012, without language restriction. STUDY SELECTION: Two independent reviewers identified parallel randomized controlled trials (RCTs) of probiotics (Lactobacillus, Bifidobacterium, Saccharomyces, Streptococcus, Enterococcus, and/or Bacillus) for the prevention or treatment of AAD. DATA EXTRACTION: Two independent reviewers extracted the data and assessed trial quality. RESULTS: A total of 82 RCTs met inclusion criteria. The majority used Lactobacillus-based interventions alone or in combination with other genera; strains were poorly documented. The pooled relative risk in a DerSimonian-Laird random-effects meta-analysis of 63 RCTs, which included 11 811 participants, indicated a statistically significant association of probiotic administration with reduction in AAD (relative risk, 0.58; 95% CI, 0.50 to 0.68; P < .001; I(2), 54%; [risk difference, -0.07; 95% CI, -0.10 to -0.05], [number needed to treat, 13; 95% CI, 10.3 to 19.1]) in trials reporting on the number of patients with AAD. This result was relatively insensitive to numerous subgroup analyses. However, there exists significant heterogeneity in pooled results and the evidence is insufficient to determine whether this association varies systematically by population, antibiotic characteristic, or probiotic preparation. CONCLUSIONS: The pooled evidence suggests that probiotics are associated with a reduction in AAD. More research is needed to determine which probiotics are associated with the greatest efficacy and for which patients receiving which specific antibiotics.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The subgroup analyses found that the Lactobacillus and Saccharomyces genera reduced incidence of antibiotic-associated diarrhoea.
“Our subgroup analyses found similarly to one previous meta-analysis37 that the Lactobacillus and Saccharomyces genera reduced incidence of AAD.”
From Probiotics for the prevention of antibiotic-associated diarrhoea: A systematic review and meta-analysis (2021) · cites this paper as [37]
Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048 · see citing works
Conducting Meta-Analyses in <i>R</i> with the <b>metafor</b> Package
Viechtbauer, W. (2010) · Journal of Statistical Software · doi:10.18637/jss.v036.i03 · Cited by 20,464 · see citing works
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955 · see citing works
Antibiotic-Associated Diarrhea
Bartlett, J. G. (2002) · New England Journal of Medicine · doi:10.1056/nejmcp011603 · Cited by 1,206 · see citing works
The Role of Probiotic Cultures in the Control of Gastrointestinal Health
Rolfe, R. D. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.396s · Cited by 925 · see citing works
McFarland, L. V. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00465.x · Cited by 872 · see citing works
Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis
D'Souza, A. L., Rajkumar, C., Cooke, J., & Bulpitt, C. J. (2002) · BMJ · doi:10.1136/bmj.324.7350.1361 · Cited by 664 · see citing works
Probiotics for the prevention of pediatric antibiotic-associated diarrhea
Goldenberg, J. Z., Lytvyn, L., Steurich, J., Parkin, P. C., Mahant, S., & Johnston, B. C. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004827.pub4 · Cited by 625 · see citing works
<i>Lactobacillus</i> Sepsis Associated With Probiotic Therapy
Land, M. H., Rouster-Stevens, K., Woods, C. R., Cannon, M. L., Cnota, J., & Shetty, A. K. (2005) · Pediatrics · doi:10.1542/peds.2004-2137 · Cited by 599 · see citing works
Hickson, M., D'Souza, A. L., Muthu, N., Rogers, T. R., Want, S., Rajkumar, C., & Bulpitt, C. J. (2007) · BMJ · doi:10.1136/bmj.39231.599815.55 · Cited by 599 · see citing works
Prevention of antibiotic-associated diarrhea by Saccharomyces boulardii: A prospective study
Surawicz, C. M., Elmer, G. W., Speelman, P., McFarland, L. V., Chinn, J., & van Belle, G. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)91613-2 · Cited by 570 · see citing works
Probiotics for preventing acute upper respiratory tract infections
Hao, Q., Dong, B. R., & Wu, T. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006895.pub3 · Cited by 569 · see citing works
Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children
Vanderhoof, J. A., Whitney, D. B., Antonson, D. L., Hanner, T. L., Lupo, J. V., & Young, R. J. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70053-3 · Cited by 536 · see citing works
Reid, G., Charbonneau, D., Erb, J., Kochanowski, B., Beuerman, D., Poehner, R., & Bruce, A. W. (2003) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(02)00465-0 · Cited by 514 · see citing works
Arvola, T., Laiho, K., Torkkeli, S., Mykkänen, H. M., Salminen, S., Maunula, L., & Isolauri, E. (1999) · PEDIATRICS · doi:10.1542/peds.104.5.e64 · Cited by 426 · see citing works
Cremonini, F., Caro, S., Covino, M., Armuzzi, A., Gabrielli, M., Santarelli, L., Nista, E. C., Cammarota, G., Gasbarrini, G., & Gasbarrini, A. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.07063.x · Cited by 341 · see citing works
Prevention of beta-lactam-associated diarrhea by Saccharomyces boulardii compared with placebo.
McFarland, L. V., Surawicz, C. M., Greenberg, R. N., Elmer, G. W., Moyer, K. A., Melcher, S. A., Bowen, K., & Cox, J. L. (1995) · PubMed · Cited by 338 · see citing works
Gao, X. W., Mubasher, M., Fang, C. Y., Reifer, C., & Miller, L. E. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.11 · Cited by 318 · see citing works
Epidemiology, Risk Factors and Treatments for Antibiotic-Associated Diarrhea
McFarland, L. V. (1998) · Digestive Diseases · doi:10.1159/000016879 · Cited by 310 · see citing works
Kotowska, M., Albrecht, P., & Szajewska, H. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02356.x · Cited by 288 · see citing works
Probiotics for the Prevention of Antibiotic‐Associated Diarrhea in Children
Szajewska, H., Canani, R. B., Guarino, A., Hojsak, I., Indrio, F., Kolaček, S., Orel, R., Shamir, R., Vandenplas, Y., van Goudoever, J. B., et al. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001081 · Cited by 264 · see citing works
Probiotics for the prevention of pediatric antibiotic-associated diarrhea
Johnston, B. C., Goldenberg, J. Z., Vandvik, P. O., Sun, X., & Guyatt, G. H. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004827.pub3 · Cited by 258 · see citing works
Safety of probiotics used to reduce risk and prevent or treat disease.
(2011) · PubMed Central · Cited by 242 · see citing works
Self-citationFavourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man
Felley, C. P., Corthesy-Theulaz, I. E., Rivero, J. L. B., Sipponen, P., Kaufmann, M., Bauerfeind, P., Wiesel, P. H., Brassart, D., Pfeifer, A. C., Blum, A. L., et al. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200101000-00005 · Cited by 220 · see citing works
Corrêa, N. B. O., Péret Filho, L. A., Penna, F. J., Lima, F. M. L. S., & Nicoli, J. R. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000159217.47419.5b · Cited by 208 · see citing works
Probiotics for preventing acute upper respiratory tract infections
Hao, Q., Lu, Z., Dong, B. R., Huang, C. Q., & Wu, T. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006895.pub2 · Cited by 206 · see citing works
Myllyluoma, E., Veijola, L., Ahlroos, T., Tynkkynen, S., Kankuri, E. M., Vapaatalo, H., Rautelin, H. I. K., & Korpela, R. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02448.x · Cited by 197 · see citing works
Sheu, B., Wu, J. ‐., Lo, C. ‐., Wu, H. ‐., Chen, J., Lin, Y. ‐., & Lin, M. ‐. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01335.x · Cited by 195 · see citing works
McFarland, L. V. (2009) · Anaerobe · doi:10.1016/j.anaerobe.2009.09.002 · Cited by 181 · see citing works
Prophylaxis against ampicillin-associated diarrhea with a lactobacillus preparation
Gotz, V. P., Romankiewicz, J. A., Moss, J., & Murray, H. W. (1979) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/36.6.754 · Cited by 177 · see citing works
Wunderlich, P. F., Braun, L., Fumagalli, I. A. L., D’Apuzzo, V., Heim, F., Karly, M., Lodi, R., Politta, G., Vonbank, F., & Zeltner, L. (1989) · Journal of International Medical Research · doi:10.1177/030006058901700405 · Cited by 177 · see citing works
Turck, D., Bernet, J., Marx, J., Kempf, H., Giard, P., Walbaum, O., Lacombe, A., Rembert, F., Toursel, F., Bernasconi, P., et al. (2003) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200307000-00004 · Cited by 172 · see citing works
Lewis, S. J., Potts, L., & Barry, R. E. (1998) · Journal of Infection · doi:10.1016/s0163-4453(98)80008-x · Cited by 172 · see citing works
Riquelme, A. J., Calvo, M. A., Guzmán, A. M., Depix, M. S., García, P. M., Pérez, C., Arrese, M. A., & Labarca, J. A. (2003) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200301000-00013 · Cited by 166 · see citing works
Beausoleil, M., Fortier, N., Guénette, S., L’Ecuyer, A., Savoie, M., Franco, M., Lachaîne, J., & Weiss, K. (2007) · Canadian Journal of Gastroenterology · doi:10.1155/2007/720205 · Cited by 162 · see citing works
Tankanow, R. M., Ross, M. B., Ertel, I. J., Dickinson, D. G., McCormick, L. S., & GARFINKEL, J. (1990) · DICP · doi:10.1177/106002809002400408 · Cited by 140 · see citing works
Cindoruk, M., Erkan, G., Karakan, T., Dursun, A., & Unal, S. (2007) · Helicobacter · doi:10.1111/j.1523-5378.2007.00516.x · Cited by 135 · see citing works
Reid, G., Bruce, A. W., & Taylor, M. (1992) · PubMed · Cited by 135 · see citing works
Ruszczyński, M., Radzikowski, A., & Szajewska, H. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03714.x · Cited by 131 · see citing works
de Bortoli, N., Leonardi, G., Ciancia, E. M., Merlo, A., Bellini, M., Costa, F., Mumolo, M. G., Ricchiuti, A., Cristiani, F., Santi, S., et al. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01085.x · Cited by 131 · see citing works
Prevention of antibiotic-associated diarrhoea by a fermented probiotic milk drink
Wenus, C., Goll, R., Loken, E. B., Biong, A. S., Halvorsen, D. S., & Florholmen, J. R. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602718 · Cited by 117 · see citing works
The Effects of Probiotics on PPI‐Triple Therapy for Helicobacter pylori Eradication
Kim, M., Kim, N., Lee, S. H., Park, Y. S., Hwang, J., Kim, J., Jeong, S., Lee, D. H., Kim, J. S., Jung, H. C., et al. (2008) · Helicobacter · doi:10.1111/j.1523-5378.2008.00601.x · Cited by 115 · see citing works
Lönnermark, E., Friman, V., Lappas, G., Sandberg, T., Berggren, A., & Adlerberth, I. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181b2683f · Cited by 110 · see citing works
Probiotics, antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in humans
Surawicz, C. M. (2003) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00054-4 · Cited by 105 · see citing works
Duman, D., Bor, S., ??z??temiz, ?., ahin, T. L., uz, D. O., tan, F. I., Vural, T., Sandkci, M., ksal, F. I., ek, L. I., et al. (2005) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200512000-00015 · Cited by 104 · see citing works
Managing antibiotic associated diarrhoea: Probiotics may help in prevention
Barbut, F., & Meynard, J. L. (2002) · BMJ · doi:10.1136/bmj.324.7350.1345 · Cited by 100 · see citing works
Koning, C. J., Jonkers, D. M. A. E., Stobberingh, E. E., Mulder, L. H. C., Rombouts, F. M., & Stockbrügger, R. W. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01547.x · Cited by 100 · see citing works
Szajewska, H., Albrecht, P., & Topczewska-Cabanek, A. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318182e716 · Cited by 99 · see citing works
Engelbrektson, A. L., Korzenik, J. R., Pittler, A., Sanders, M. E., Klaenhammer, T. R., Leyer, G. J., & Kitts, C. L. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47615-0 · Cited by 95 · see citing works
Song, M., Park, D. I., Park, J. H., Kim, H. J., Cho, Y. K., Sohn, C. I., Jeon, W. K., & Kim, B. I. (2010) · Helicobacter · doi:10.1111/j.1523-5378.2010.00751.x · Cited by 93 · see citing works
Tursi, A., Brandimarte, G., Giorgetti, G. M., & Modeo, M. E. (2004) · PubMed · Cited by 93 · see citing works
Probiotics for the Prevention of Antibiotic-Associated Diarrhea
Kopacz, K., & Phadtare, S. (2022) · Healthcare · doi:10.3390/healthcare10081450 · Cited by 85 · see citing works
de Vrese, M., Kristen, H., Rautenberg, P., Laue, C., & Schrezenmeir, J. (2011) · Journal of Dairy Research · doi:10.1017/s002202991100063x · Cited by 84 · see citing works
Cimperman, L., Bayless, G., Best, K., Diligente, A., Mordarski, B. A., Oster, M., Smith, M., Vatakis, F., Wiese, D. M., Steiber, A. L., et al. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3182166a42 · Cited by 81 · see citing works
The Probiotic Effect of Saccharomyces boulardii in a Pediatric Age Group
Erdeve, Ö. (2004) · Journal of Tropical Pediatrics · doi:10.1093/tropej/50.4.234 · Cited by 75 · see citing works
La Rosa, M., Bottaro, G., Gulino, N., Gambuzza, F., Di Forti, F., Inì, G., & Tornambè, E. (2003) · PubMed · Cited by 74 · see citing works
Conway, S., Hart, A. R., Clark, A., & Harvey, I. M. (2007) · British Journal of General Practice · doi:10.3399/096016407782604811 · Cited by 71 · see citing works
Sullivan, Å. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg346 · Cited by 71 · see citing works
Merenstein, D. J., Foster, J., & D’Amico, F. (2009) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2009.119 · Cited by 61 · see citing works
Lactobacillus Sepsis Associated With Probiotic Therapy
Berger, R. E. (2005) · The Journal of Urology · doi:10.1016/s0022-5347(01)68804-9 · Cited by 60 · see citing works
Zoppi, G., Cinquetti, M., Benini, A., Bonamini, E., & Minelli, E. B. (2001) · Current Therapeutic Research · doi:10.1016/s0011-393x(01)89006-8 · Cited by 59 · see citing works
Song, H. J., Kim, J.-Y., Jung, S.-A., Kim, S.-E., Park, H.-S., Jeong, Y., Hong, S. P., Cheon, J. H., Kim, W. H., Kim, H.-J., et al. (2010) · Journal of Korean Medical Science · doi:10.3346/jkms.2010.25.12.1784 · Cited by 58 · see citing works
Schrezenmeir, J., Heller, K. J., McCue, M. J., Llamas, C. V., Lam, W., Burow, H., Kindling-Rohracker, M., Fischer, W., Sengespeik, H. C., Comer, G. M., et al. (2004) · Clinical Pediatrics · doi:10.1177/000992280404300305 · Cited by 56 · see citing works
Prevention of antibiotic-associated diarrhea in infants by probiotics.
Jirapinyo, P., Densupsoontorn, N., Thamonsiri, N., & Wongarn, R. (2002) · PubMed · Cited by 56 · see citing works
Effect of Probiotics on Helicobacter Pylori Eradication
Park, S. K., Park, D. I., Choi, J. S., Kang, M.-S., Park, J. H., Kim, H. J., Cho, Y. K., Sohn, C. I., Jeon, W. K., & Kim, B. I. (2019) · Case Medical Research · doi:10.31525/ct1-nct04034641 · Cited by 55 · see citing works
Szymański, H., Armańska, M., Kowalska‐Duplaga, K., & Szajewska, H. (2008) · Digestion · doi:10.1159/000151300 · Cited by 54 · see citing works
Saccharomyces boulardiiFungemia in a Patient Receiving Ultra‐levure Therapy
Frédénucci, I., Chomarat, M., Boucaud, C., & Flandrois, J. (1998) · Clinical Infectious Diseases · doi:10.1086/517685 · Cited by 51 · see citing works
Safdar, N., Barigala, R., Said, A., & McKinley, L. L. (2008) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2008.00980.x · Cited by 50 · see citing works
Fungämie nach oraler Gabe vonSaccharomyces boulardiibei einem multimorbiden Patienten
Lestin-Bernstein, F., Pertschy, A., & Rimek, D. (2003) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-2003-44948 · Cited by 47 · see citing works
Efficacy of probiotics in Helicobacter pylori eradication therapy
Yaşar, B., Abut, E., Kayadibi, H., TOROS, B., Sezikli, M., Akkan, Z., Keskin, Ö., & Kurdaş, O. Ö. (2010) · The Turkish Journal of Gastroenterology · doi:10.4318/tjg.2010.0090 · Cited by 44 · see citing works
Probiotics in antibiotic-associated diarrhoea
Cremonini, F., Caro, S. D., Santarelli, L., Gabrielli, M., Candelli, M., Nista, E. C., Lupascu, A., Gasbarrini, A., & Gasbarrini, A. (2002) · Digestive and Liver Disease · doi:10.1016/s1590-8658(02)80171-2 · Cited by 43 · see citing works
[Saccharomyces boulardii fungemia. Apropos of a case].
Zunic, P., Lacotte, J., Pegoix, M., Buteux, G., Leroy, G., Mosquet, B., & Moulin, M. (1991) · PubMed · Cited by 41 · see citing works
Lighthouse, J. (2004) · Hepatology Research · doi:10.1016/j.hepres.2003.11.005 · Cited by 40 · see citing works
Yoon, H., Kim, N., Kim, J. Y., Park, S. Y., Park, J. H., Jung, H. C., & Song, I. S. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06477.x · Cited by 38 · see citing works
Koning, C. J., Jonkers, D. M. A. E., Smidt, H., Rombouts, F. M., Pennings, H.-J., Wouters, E. F. �., Stobberingh, E. E., & Stockbrügger, R. W. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509993497 · Cited by 36 · see citing works
Bravo, M. V., Bunout, D. C., Leiva, L., de la Maza, M. P., Barrera, G., de la Maza, J., & Hirsch, S. (2008) · PubMed · Cited by 34 · see citing works
Osterman, M. T. (2008) · Yearbook of Gastroenterology · doi:10.1016/s0739-5930(08)79195-5 · Cited by 34 · see citing works
[Probiotics as prophylactic agents against antibiotic-associated diarrhea in hospitalized patients].
Stein, G. Y., Nanim, R., Karniel, E., Moskowitz, I., & Zeidman, A. (2007) · PubMed · Cited by 20 · see citing works
Piechno, S., Séguin, P., & Gangneux, J. (2007) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03022650 · Cited by 14 · see citing works
Worona-Dibner, L. (2014) · PubMed · Cited by 11 · see citing works
Monteiro, E., Fernandes, J. P., Vieira, M. R., Correia, J. P., Caetano, J. M., Ribeiro, T., Antunes, A. B., Noronha, R., Batista, F., Reis, L., et al. (1981) · PubMed · Cited by 10 · see citing works
Guslandi, M. (2006) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0627 · Cited by 9 · see citing works
Should Probiotics be Routine Therapy for the Prevention of Antibiotic-associated Diarrhea?
Katz, J. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181bdf010 · Cited by 7 · see citing works
[Prevention of antibiotic-associated diarrhea in children].
Zakharova, I. N., Dmitrieva, I. A., Горюхина, О. М., & Ng, S. (2011) · PubMed · Cited by 7 · see citing works
Selinger, C. P., Lockett, M., Bell, A., Sebastian, S., & Haslam, N. (2011) · Gut · doi:10.1136/gut.2011.239301.7 · Cited by 6 · see citing works
Effectivness of Probiotic on Treatment of Helicobacter Pylori Infection in Children
Saneeyan, H., Layegh, S., & Rahimi, H. (2011) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 6 · see citing works
Antibiotic-Associated Diarrhea
Bartlett, J. G. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9780511722240.051 · Cited by 5 · see citing works
Woo, K. H., Chen, X., & Injeti, E. R. (2011) · The Journal of Clinical Pharmacology · doi:10.1177/0091270010418046 · Cited by 5 · see citing works
Probiotics and antibiotic associated diarrhoea
Battle, M. (2002) · BMJ · doi:10.1136/bmj.325.7369.901/b · Cited by 3 · see citing works
Helicobacter Pylori Eradication
Rakıcı, H. (2014) · http://isrctn.com/ · doi:10.1186/isrctn36321686 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592 · see citing works
Mendes, R., Garbeva, P., & Raaijmakers, J. M. (2013) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12028 · Cited by 2,836 · see citing works
Clostridium difficile Infection
Leffler, D. A., & LaMont, J. T. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1403772 · Cited by 1,461 · see citing works
The pros, cons, and many unknowns of probiotics
Suez, J., Zmora, N., Segal, E., & Elinav, E. (2019) · Nature Medicine · doi:10.1038/s41591-019-0439-x · Cited by 1,398 · see citing works
Mechanisms of action of probiotics
Plaza-Diaz, J., Ruiz-Ojeda, F. J., Gil-Campos, M., & Gil, A. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy063 · Cited by 1,423 · see citing works
The composition of the gut microbiota throughout life, with an emphasis on early life
Rodríguez, J. M., Murphy, K., Stanton, C., Ross, R. P., Kober, O. I., Juge, N., Avershina, E., Rudi, K., Narbad, A., Jenmalm, M. C., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26050 · Cited by 1,320 · see citing works
Probiotics, prebiotics and synbiotics- a review
Pandey, K. R., Naik, S. R., & Vakil, B. V. (2015) · Journal of Food Science and Technology · doi:10.1007/s13197-015-1921-1 · Cited by 1,350 · see citing works
Debast, S. B., Bauer, M. P., & Kuijper, E. J. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12418 · Cited by 1,212 · see citing works
Suez, J., Zmora, N., Zilberman-Schapira, G., Mor, U., Dori-Bachash, M., Bashiardes, S., Zur, M., Regev-Lehavi, D., Ben-Zeev Brik, R., Federici, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.047 · Cited by 1,184 · see citing works
Microorganisms with Claimed Probiotic Properties: An Overview of Recent Literature
Fijan, S. (2014) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph110504745 · Cited by 1,059 · see citing works
Health Benefits of Probiotics: A Review
Kechagia, M., Basoulis, D., Konstantopoulou, S. M., Dimitriadi, D., Gyftopoulou, K., Skarmoutsou, N., & Fakiri, E. (2013) · ISRN Nutrition · doi:10.5402/2013/481651 · Cited by 1,014 · see citing works
Langdon, A. E., Crook, N., & Dantas, G. A. (2016) · Genome Medicine · doi:10.1186/s13073-016-0294-z · Cited by 917 · see citing works
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
Goldenberg, J. Z., Ma, S. S., Saxton, J. D., Martzen, M. R., Vandvik, P. O., Thorlund, K., Guyatt, G. H., & Johnston, B. C. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006095.pub3 · Cited by 741 · see citing works
Shane, A. L., Mody, R. K., Crump, J. A., Tarr, P. I., Steiner, T. S., Kotloff, K., Langley, J. M., Wanke, C., Warren, C. A., Cheng, A. C., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix669 · Cited by 627 · see citing works
Mcfarland, L. V., Evans, C., & Goldstein, E. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00124 · Cited by 569 · see citing works
The Gastrointestinal Microbiome: A Review
Barko, P. C., McMichael, M. A., Swanson, K. S., & Williams, D. A. (2018) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.14875 · Cited by 750 · see citing works
Microbial regulation of organismal energy homeostasis
Cani, P. D., Van Hul, M., Lefort, C., Depommier, C., Rastelli, M., & Everard, A. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0017-4 · Cited by 569 · see citing works
Nutrition, immunity and COVID-19
Calder, P. C. (2020) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2020-000085 · Cited by 587 · see citing works
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children
Goldenberg, J. Z., Yap, C., Lytvyn, L., Lo, C. K.-F., Beardsley, J., Mertz, D., & Johnston, B. C. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006095.pub4 · Cited by 550 · see citing works
Shane, A. L., Mody, R. K., Crump, J. A., Tarr, P. I., Steiner, T. S., Kotloff, K. L., Langley, J. M., WANKE, C. A., Warren, C. A., Cheng, A. C., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix959 · Cited by 541 · see citing works
Intestinal microbiota, diet and health
Power, S. E., O'Toole, P. W., Stanton, C., Ross, R. P., & Fitzgerald, G. F. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114513002560 · Cited by 476 · see citing works
Fiocchi, A., Pawankar, R., Cuello-Garcia, C., Ahn, K., Al-Hammadi, S., Agarwal, A., Beyer, K., Burks, W., Canonica, G. W., Ebisawa, M., et al. (2015) · World Allergy Organization Journal · doi:10.1186/s40413-015-0055-2 · Cited by 473 · see citing works
Probiotics, gut microbiota and health
Butel, M. J. (2013) · Médecine et Maladies Infectieuses · doi:10.1016/j.medmal.2013.10.002 · Cited by 459 · see citing works
Diagnosis and Treatment ofClostridium difficilein Adults
Bagdasarian, N., Rao, K. K., & Malani, P. (2015) · JAMA · doi:10.1001/jama.2014.17103 · Cited by 445 · see citing works
ACG Clinical Guideline: Diagnosis, Treatment, and Prevention of Acute Diarrheal Infections in Adults
Riddle, M. S., DuPont, H. L., & Connor, B. A. (2016) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.126 · Cited by 435 · see citing works
Metabolic and nutritional support of critically ill patients: consensus and controversies
Preiser, J.-C., van Zanten, A. R., Berger, M. M., Biolo, G., Casaer, M. P., Doig, G. S., Griffiths, R. D., Heyland, D. K., Hiesmayr, M., Iapichino, G., et al. (2015) · Critical Care · doi:10.1186/s13054-015-0737-8 · Cited by 416 · see citing works
The role of the bacterial microbiome in lung disease
Dickson, R. P., Erb‐Downward, J. R., & Huffnagle, G. B. (2013) · Expert Review of Respiratory Medicine · doi:10.1586/ers.13.24 · Cited by 412 · see citing works
Resistance of Gram-Positive Bacteria to Current Antibacterial Agents and Overcoming Approaches
Jubeh, B., Breijyeh, Z., & Karaman, R. (2020) · Molecules · doi:10.3390/molecules25122888 · Cited by 400 · see citing works
Allen, S. J., Wareham, K., Wang, D., Bradley, C., Hutchings, H. A., Harris, W., Dhar, A., Brown, H., Foden, A. P., Gravenor, M. B., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61218-0 · Cited by 385 · see citing works
Modulating the microbiome to improve therapeutic response in cancer
McQuade, J. L., Daniel, C. R., Helmink, B. A., & Wargo, J. A. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30952-5 · Cited by 376 · see citing works
Thirty Years of Lactobacillus rhamnosus GG
Capurso, L. (2019) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001170 · Cited by 385 · see citing works
Johnston, B. C., Ma, S. S. Y., Goldenberg, J. Z., Thorlund, K., Vandvik, P. O., Loeb, M., & Guyatt, G. H. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-12-201212180-00563 · Cited by 367 · see citing works
Moal, V. L.-L., & Servin, A. L. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00080-13 · Cited by 355 · see citing works
Probiotics for Prevention and Treatment of Diarrhea
Guandalini, S. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3182257e98 · Cited by 351 · see citing works
Inflammation in Renal Diseases: New and Old Players
Andrade‐Oliveira, V., Foresto‐Neto, O., Watanabe, I. K. M., Zatz, R., & Câmara, N. O. S. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01192 · Cited by 330 · see citing works
Understanding the impact of antibiotic perturbation on the human microbiome
Schwartz, D. J., Langdon, A. E., & Dantas, G. A. (2020) · Genome Medicine · doi:10.1186/s13073-020-00782-x · Cited by 329 · see citing works
A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea
Pan, J., Gong, G., Wang, Q., Shang, J., He, Y., Catania, C., Birnbaum, D., Li, Y., Jia, Z., Zhang, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29672-z · Cited by 315 · see citing works
Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks
Morgun, A., Dzutsev, A., Dong, X., Greer, R. L., Sexton, D. J., Ravel, J., Schuster, M., Hsiao, W., Matzinger, P., & Shulzhenko, N. (2015) · Gut · doi:10.1136/gutjnl-2014-308820 · Cited by 304 · see citing works
Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis
Manzanares, W., Lemieux, M., Langlois, P. L., & Wischmeyer, P. E. (2016) · Critical Care · doi:10.1186/s13054-016-1434-y · Cited by 295 · see citing works
Microbiota-Targeted Therapies: An Ecological Perspective
Lemon, K. P., Armitage, G. C., Relman, D. A., & Fischbach, M. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004183 · Cited by 282 · see citing works
Manipulating the gut microbiota to maintain health and treat disease
Scott, K. P., Antoine, J., Midtvedt, T., & van Hemert, S. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.25877 · Cited by 284 · see citing works
Calder, P. C. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113001286 · Cited by 283 · see citing works
Probiotics importance and their immunomodulatory properties
Yousefi, B., Eslami, M., Ghasemian, A., Kokhaei, P., Farrokhi, A. S., & Darabi, N. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27559 · Cited by 278 · see citing works
Guidelines for the prevention and treatment of travelers’ diarrhea: a graded expert panel report
Riddle, M. S., Connor, B. A., Beeching, N. J., DuPont, H. L., Hamer, D. H., Kozarsky, P. E., Libman, M., Steffen, R. J., Taylor, D. N., Tribble, D. R., et al. (2017) · Journal of Travel Medicine · doi:10.1093/jtm/tax026 · Cited by 275 · see citing works
African fermented foods and probiotics
Franz, C. M. A. P., Huch, M., Mathara, J. M., Abriouel, H., Benomar, N., Reid, G., Gálvez, A., & Holzapfel, W. H. (2014) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2014.08.033 · Cited by 265 · see citing works
Probiotics for the Prevention of Antibiotic‐Associated Diarrhea in Children
Szajewska, H., Canani, R. B., Guarino, A., Hojsak, I., Indrio, F., Kolaček, S., Orel, R., Shamir, R., Vandenplas, Y., van Goudoever, J. B., et al. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001081 · Cited by 264 · see citing works
Cao, J., Yu, Z., Liu, W., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103643 · Cited by 258 · see citing works
Lactobacilli and Bifidobacteria in Human Breast Milk
Soto, A., Martín, V., Jiménez, E., Mader, I., Rodríguez, J. M., & Fernández, L. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000347 · Cited by 252 · see citing works
Microbiome-based interventions to modulate gut ecology and the immune system
Hitch, T. C. A., Hall, L. J., Walsh, S. K., Leventhal, G. E., Slack, E. M. C., de Wouters, T., Walter, J., & Clavel, T. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00564-1 · Cited by 250 · see citing works
Johnstone, J., Meade, M., Lauzier, F., Marshall, J., Duan, E., Dionne, J., Arabi, Y. M., Heels-Ansdell, D., Thabane, L., Lamarche, D., et al. (2021) · JAMA · doi:10.1001/jama.2021.13355 · Cited by 226 · see citing works
Szajewska, H., & Kołodziej, M. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13404 · Cited by 224 · see citing works
Szajewska, H., & Kołodziej, M. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13344 · Cited by 218 · see citing works
Cui, Y., Wang, Q., Chang, R., Zhou, X., & Xu, C. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b00080 · Cited by 217 · see citing works
Hungin, A. P. S., Mulligan, C., Pot, B., Whorwell, P., Agréus, L., Fracasso, P., Lionis, C., Mendive, J., Philippart de Foy, J.-M., Rubin, G., et al. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12460 · Cited by 212 · see citing works
Probiotics for Prevention and Treatment of Diarrhea
Guarino, A., Guandalini, S., & Vecchio, A. L. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000349 · Cited by 217 · see citing works
Vandenplas, Y., Huys, G. R. B., & Daube, G. (2014) · Jornal de Pediatria · doi:10.1016/j.jped.2014.08.005 · Cited by 218 · see citing works
Probiotic approach to prevent antibiotic resistance
Ouwehand, A. C., Forssten, S., Hibberd, A. A., Lyra, A., & Stahl, B. (2016) · Annals of Medicine · doi:10.3109/07853890.2016.1161232 · Cited by 216 · see citing works
Chudzik, A., Orzyłowska, A., Rola, R., & Stanisz, G. J. (2021) · Biomolecules · doi:10.3390/biom11071000 · Cited by 212 · see citing works
Blaabjerg, S., Artzi, D., & Aabenhus, R. (2017) · Antibiotics · doi:10.3390/antibiotics6040021 · Cited by 208 · see citing works
World Gastroenterology Organisation Global Guidelines: Probiotics and Prebiotics
Guarner, F., Sanders, M. E., Szajewska, H., Cohen, H., Eliakim, R., Herrera-deGuise, C., Karakan, T., Merenstein, D., Piscoya, A., Ramakrishna, B., et al. (2024) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000002002 · Cited by 209 · see citing works
Functional Foods, Nutraceuticals and Probiotics: A Focus on Human Health
Damián, M. R., Cortes‐Perez, N. G., Quintana, E. T., Ortiz‐Moreno, A., Garfias-Noguez, C., Cruceño-Casarrubias, C. E., Pardo, M. E. S., & Bermúdez‐Humarán, L. G. (2022) · Microorganisms · doi:10.3390/microorganisms10051065 · Cited by 209 · see citing works
Probiotics and their potential applications in active edible films and coatings
Espitia, P. J. P., Batista, R. A., de Azeredo, H. M. C., & Otoni, C. G. (2016) · Food Research International · doi:10.1016/j.foodres.2016.10.026 · Cited by 192 · see citing works
Related actions of probiotics and antibiotics on gut microbiota and weight modification
Angelakis, E., Merhej, V., & Raoult, D. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70179-8 · Cited by 190 · see citing works
Hsieh, M., Tsai, W.-H., Jheng, Y.-P., Su, S., Wang, S., Lin, C., Chen, Y.-H., & Chang, W. (2018) · Scientific Reports · doi:10.1038/s41598-018-35014-1 · Cited by 182 · see citing works
Probiotics and COVID-19: one size does not fit all
Mak, J. W. Y., Chan, F. K. L., & Ng, S. C. (2020) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(20)30122-9 · Cited by 182 · see citing works
Chamberlain, R., & Lau, C. (2016) · International Journal of General Medicine · doi:10.2147/ijgm.s98280 · Cited by 177 · see citing works
Disruption of the gut ecosystem by antibiotics.
Yoon, M. Y., & Yoon, S. S. (2018) · Yonsei Medical Journal · doi:10.3349/ymj.2018.59.1.4 · Cited by 175 · see citing works
HIV and the Gut Microbiota: Composition, Consequences, and Avenues for Amelioration
Vujkovic-Cvijin, I., & Somsouk, M. (2019) · Current HIV/AIDS Reports · doi:10.1007/s11904-019-00441-w · Cited by 175 · see citing works
Cremon, C., Barbaro, M. R., Ventura, M., & Barbara, G. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.08.010 · Cited by 173 · see citing works
Oh, B., Kim, B. S., Kim, J. W., Kim, J. S., Koh, S., Kim, B. G., Lee, K. L., & Chun, J. (2015) · Helicobacter · doi:10.1111/hel.12270 · Cited by 164 · see citing works
Gut microbiota, the pharmabiotics they produce and host health
Patterson, E., Cryan, J. F., Fitzgerald, G. F., Ross, R. P., Dinan, T. G., & Stanton, C. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665114001426 · Cited by 165 · see citing works
Hagihara, M., Kuroki, Y., Ariyoshi, T., Higashi, S., Fukuda, K., Yamashita, R., Matsumoto, A., Mori, T., Mimura, K., Yamaguchi, N., et al. (2020) · iScience · doi:10.1016/j.isci.2019.100772 · Cited by 162 · see citing works
Varankovich, N. V., Nickerson, M. T., & Korber, D. R. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00685 · Cited by 162 · see citing works
Role of the microbiome, probiotics, and ‘dysbiosis therapy’ in critical illness
Wischmeyer, P. E., McDonald, D. T., & Knight, R. D. (2016) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000321 · Cited by 161 · see citing works
Goodman, C., Keating, G., Georgousopoulou, E., Hespe, C., & Levett, K. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-043054 · Cited by 163 · see citing works
Feeding the Critically Ill Patient
McClave, S. A., Martindale, R. G., Rice, T. W., & Heyland, D. K. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000654 · Cited by 156 · see citing works
Publication Bias in Meta-Analysis: Confidence Intervals for Rosenthal’s Fail-Safe Number
Fragkos, K. C., Tsagris, M., & Frangos, C. C. (2014) · International Scholarly Research Notices · doi:10.1155/2014/825383 · Cited by 159 · see citing works
van Hemert, S., Breedveld, A. C., Rovers, J. M. P., Vermeiden, J. P. W., Witteman, B. J. M., Smits, M. G., & de Roos, N. M. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00241 · Cited by 150 · see citing works
Comparison of pediatric and adult antibiotic-associated diarrhea andClostridium difficileinfections
McFarland, L. V., Özen, M., Dinleyici, E. Ç., & Goh, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i11.3078 · Cited by 152 · see citing works
Smolińska, S., Popescu, F., & Zemelka‐Wiącek, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14113673 · Cited by 153 · see citing works
Summary Points and Consensus Recommendations From the North American Surgical Nutrition Summit
McClave, S. A., Kozar, R. A., Martindale, R. G., Heyland, D. K., Braga, M., Carli, F., Drover, J., Flum, D. R., Gramlich, L. M., Herndon, D. N., et al. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113495892 · Cited by 150 · see citing works
Nutrition Optimization Prior to Surgery
Evans, D. C., Martindale, R. G., Kiraly, L. N., & Jones, C. M. (2013) · Nutrition in Clinical Practice · doi:10.1177/0884533613517006 · Cited by 150 · see citing works
Effect of Oral Administration of Metronidazole or Prednisolone on Fecal Microbiota in Dogs
Igarashi, H., Maeda, S., Ohno, K., Horigome, A., Odamaki, T., & Tsujimoto, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107909 · Cited by 149 · see citing works
Zhang, W., Qu, W., Wang, H., & Yan, H. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01254-5 · Cited by 152 · see citing works
Feng, P., Ye, Z., Kakade, A., Virk, A. K., Li, X., & Liu, P. (2018) · Nutrients · doi:10.3390/nu11010022 · Cited by 148 · see citing works
Impact of probiotic supplements on microbiome diversity following antibiotic treatment of mice
Grazul, H., Kanda, L. L., & Gondek, D. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1138197 · Cited by 135 · see citing works
Adaptive Strategies of the Candidate Probiotic E. coli Nissle in the Mammalian Gut
Crook, N., Ferreiro, A. L., Gasparrini, A. J., Pesesky, M. W., Gibson, M. K., Wang, B., Sun, X., Condiotte, Z. J., Dobrowolski, S., Peterson, D. A., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.02.005 · Cited by 133 · see citing works
Effects of Four Antibiotics on the Diversity of the Intestinal Microbiota
Huang, C., Feng, S., Huo, F., & Liu, H. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01904-21 · Cited by 137 · see citing works
Antibiotics, obesity and the link to microbes - what are we doing to our children?
Turta, O., & Rautava, S. (2016) · BMC Medicine · doi:10.1186/s12916-016-0605-7 · Cited by 129 · see citing works
Current understanding of antibiotic-associated dysbiosis and approaches for its management
Kesavelu, D., & Jog, P. P. (2023) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361231154443 · Cited by 148 · see citing works
Lactobacillus reuteri Strain Combination In Helicobacter pylori Infection
Francavilla, R., Polimeno, L., Demichina, A., Maurogiovanni, G., Principi, M., Scaccianoce, G., Ierardi, E., Russo, F., Riezzo, G., Leo, A. D., et al. (2013) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000007 · Cited by 125 · see citing works
Calder, P. C., Ortega, E. F., Meydani, S. N., Adkins, Y. C., Stephensen, C. B., Thompson, B., & Zwickey, H. L. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac052 · Cited by 136 · see citing works
Zhang, W., Zhu, B., Xu, J., Liu, Y., Qiu, E., Li, Z., Li, Z., He, Y., Zhou, H., Bai, Y., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01040 · Cited by 123 · see citing works
Modulation of microbiota as treatment for intestinal inflammatory disorders: An uptodate
Gallo, A., Passaro, G., Gasbarrini, A., Landolfi, R., & Montalto, M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i32.7186 · Cited by 118 · see citing works
Probiotics modify human intestinal mucosa-associated microbiota in patients with colorectal cancer
Gao, Z., Guo, B., Gao, R., Zhu, Q., Wu, W., & Qin, H. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4124 · Cited by 115 · see citing works
Probiotic bacteria in cancer patients undergoing chemotherapy and radiation therapy
Mego, M., Holec, V., Drgona, L., Hainova, K., Ciernikova, S., & Zajac, V. (2013) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2013.08.018 · Cited by 112 · see citing works
Impact of Antibiotics on Necrotizing Enterocolitis and Antibiotic-Associated Diarrhea
Silverman, M. A., Konnikova, L., & Gerber, J. S. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.09.010 · Cited by 113 · see citing works
Aumeeruddy, M. Z., Zengin, G., & Mahomoodally, M. F. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.11.030 · Cited by 112 · see citing works
Prebiotics and Probiotics for Gastrointestinal Disorders
Rau, S., Gregg, A., Yaceczko, S. D., & Limketkai, B. N. (2024) · Nutrients · doi:10.3390/nu16060778 · Cited by 121 · see citing works
The quest for probiotic effector molecules—Unraveling strain specificity at the molecular level
Lee, I.-C., Tomita, S., Kleerebezem, M., & Bron, P. A. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.09.010 · Cited by 109 · see citing works
- Authors
- Newberry, S. J.
- Affiliations
- RAND Corporation (US)
- Corresponding author
- Newberry, Sydne J.
- ORCID
- Newberry, Sydne J.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2012-05-09
- Volume
- 307
- Issue
- 18
- Pages
- 1959
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1966875539
- Cited by
- 870
- References
- 92
- Citations by year
- 2026: 36 · 2025: 51 · 2024: 49 · 2023: 49 · 2022: 75 · 2021: 64 · 2020: 52 · 2019: 71 · 2018: 42 · 2017: 50 · 2016: 64 · 2015: 90 · 2014: 66 · 2013: 78 · 2012: 32
- FWCI
- 130.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (290-2007-10062-I)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- probiotics, antibiotic-associated diarrhea, diarrhea prevention, Lactobacillus, Bifidobacterium, Saccharomyces, Streptococcus, Enterococcus, Bacillus, antibiotic adverse effects, probiotic efficacy
- MeSH terms
- Anti-Bacterial Agents, Diarrhea, Humans, Randomized Controlled Trials as Topic, Probiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
