G6PD Deficiency and Breast Cancer
Abstract
A study of the relative 2dG6P utilization in mononuclear cells from a group of 150 women with breast cancer was undertaken to evaluate a possible negative correlation between G6PD deficiency and cancer, as suggested by some authors. Twenty-one women (14.00 %) were heterozygotes and 2 were homozygotes (1.33 %). The prevalence found was not different from that expected. It would therefore seem that the G6PD Mediterranean allele does not play a protective role against the development of breast cancer.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Smaller case control studies have failed to demonstrate a relationship between G6PD deficiency and cancer.
“smaller case control studies have also failed to demonstrate a relationship (Forteleoni et al., 1988; Pisano et al., 1991)”
From Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate (2012) · cites this paper as Forteleoni et al., 1988
Cites
Gaetani, G., Ferraris, A. M., Galiano, S., et al. (1982) · Blood · doi:10.1182/blood.v59.1.76.76 · Cited by 52 · see citing works
Self-citationGlucose-6-Phosphate Dehydrogenase Deficiency and the Incidence of Cancer
Beaconsfield, P., Rainsbury, R., & Kalton, G. (2009) · Oncologia · doi:10.1159/000224280 · Cited by 51 · see citing works
Does G6PD deficiency protect against cancer? A critical review.
Cocco, P. (1987) · Journal of Epidemiology & Community Health · doi:10.1136/jech.41.2.89 · Cited by 39 · see citing works
Neonatal jaundice and severity of glucose-6-phosphate dehydrogenase deficiency in Sardinian babies
Meloni, T., Cutillo, S., Testa, U., et al. (1987) · Early Human Development · doi:10.1016/0378-3782(87)90026-0 · Cited by 36 · see citing works
Self-citationG.-6-P.D. DEFICIENCY AND CANCER
Sulis, E. (1972) · The Lancet · doi:10.1016/s0140-6736(72)91416-x · Cited by 33 · see citing works
2-deoxy-glucose-6-phosphate utilization in the study of glucose-6-phosphate dehydrogenase mosaicism.
Ferraris, A., Giuntini, P., Galiano, S., et al. (1981) · PubMed · Cited by 28 · see citing works
Self-citationThe Association between Glucose-6-Phosphate Dehydrogenase Deficiency and Cancer in American Negroes
Naik, S. N., & Anderson, D. (2009) · Oncology · doi:10.1159/000224585 · Cited by 24 · see citing works
Glucose 6-phosphate dehydrogenase deficiency and incidence of hematologic malignancy.
Ferraris, A., Broccia, G., Meloni, T., Forteleoni, G., & Gaetani, G. F. (1988) · Europe PMC (PubMed Central) · Cited by 22 · see citing works
Self-citationPreliminary Results of a Geographic Correlation Study on G6PD Deficiency and Cancer
Cocco, P., Manca, P., & Dessı̀, S. (1987) · Toxicologic Pathology · doi:10.1177/019262338701500116 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233 · see citing works
- Authors
- Forteleoni, G., Argiolas, L., Farris, A., Ferraris, A. M., Gaetani, G. F., & Meloni, T.
- Affiliations
- University of Sassari (IT)
- Cattedra di Ematologia, Università di Genova
- University of Genoa (IT)
- ORCID
- Meloni, Tullio
- Venue
- Tumori Journal
- Publisher
- SAGE Publications
- Published
- 1988-12
- Volume
- 74
- Issue
- 6
- Pages
- 665-667
- ISSN
- 0300-8916 (ISSN-L)
- 2038-2529
- OpenAlex
- W2419492306
- Cited by
- 15
- References
- 9
- Citations by year
- 2024: 1 · 2021: 2 · 2020: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Tumori Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Keywords
- glucose-6-phosphate dehydrogenase deficiency, breast cancer, mononuclear cells, heterozygotes, homozygotes, cancer susceptibility, genetic polymorphism
- MeSH terms
- Adult, Alleles, Breast Neoplasms, Female, Glucosephosphate Dehydrogenase, Glucosephosphate Dehydrogenase Deficiency, Humans, Middle Aged
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
