Glucose-6-Phosphate Dehydrogenase Deficiency and Lung Cancer: A Hospital Based Case-Control Study
Abstract
A hospital based case-control study was conducted to test the hypothesis of a lower lung cancer risk in G6PD-deficient subjects. Cases were 156 male patients with lung cancer, admitted to « Binaghi » Hospital, Local Health Unit (USL) 20, Cagliari (Italy), between January 1984 and November 1986. Controls were 235 male patients, admitted to the same hospital In the same time period, for diseases other than cancer (all types) and hemolytic anemia. No decrease of the lung cancer risk was found in G6PD-deficient subjects. This result, in line with recent reports in the literature, suggests that the genetic condition of G6PD deficiency does not provide significant protection against the development of lung cancer in humans.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Smaller case control studies have failed to demonstrate a relationship between G6PD deficiency and cancer.
“smaller case control studies have also failed to demonstrate a relationship (Forteleoni et al., 1988; Pisano et al., 1991)”
From Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate (2012) · cites this paper as Pisano et al., 1991
Cites
RE: “ESTIMABILITY AND ESTIMATION IN CASE-REFERENT STUDIES”
Halperin, M. (1977) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112409 · Cited by 1,546 · see citing works
ESTIMABILITY AND ESTIMATION IN CASE-REFERENT STUDIES
Miettinen, O. S. (1976) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112220 · Cited by 1,322 · see citing works
Human glucose-6-phosphate dehydrogenase variants.
Yoshida, A., Beutler, E., & Motulsky, A. G. (1971) · PubMed · Cited by 217 · see citing works
COMPONENTS OF THE CRUDE RISK RATIO
Miettinen, O. S. (1972) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a121443 · Cited by 169 · see citing works
Favism and Thalassæmia in Sardinia and their Relationship to Malaria
SINISCALCO, M., Bernini, L. F., Latte, B., & Motulsky, A. G. (1961) · Nature · doi:10.1038/1901179a0 · Cited by 168 · see citing works
Schwartz, A., & Tannen, R. H. (1981) · Carcinogenesis · doi:10.1093/carcin/2.12.1335 · Cited by 123 · see citing works
Ramot, B., Szeinberg, A., Adam, A., Sheba, C., & Gafni, D. (1959) · Journal of Clinical Investigation · doi:10.1172/jci103943 · Cited by 113 · see citing works
Ramot, B., Fisher, S., Szeinberg, A., Adam, A., Sheba, C., & Gafni, D. (1959) · Journal of Clinical Investigation · doi:10.1172/jci104004 · Cited by 78 · see citing works
Hepatic cholesterol in lead nitrate induced liver hyperplasia
Dessı̀, S., Batetta, B., Laconi, E., Ennas, C., & Pani, P. (1984) · Chemico-Biological Interactions · doi:10.1016/0009-2797(84)90140-6 · Cited by 59 · see citing works
Pashko, L. L., Hard, G. C., Rovito, R. J., Williams, J. R., Sobel, E. L., & Schwartz, A. G. (1985) · PubMed · Cited by 55 · see citing works
Glucose-6-Phosphate Dehydrogenase Deficiency and the Incidence of Cancer
Beaconsfield, P., Rainsbury, R., & Kalton, G. (2009) · Oncologia · doi:10.1159/000224280 · Cited by 51 · see citing works
Ledda‐Columbano, G. M., Columbano, A., Dessı̀, S., Coni, P., Chiodino, C., & Pani, P. (1985) · Carcinogenesis · doi:10.1093/carcin/6.9.1371 · Cited by 43 · see citing works
Does G6PD deficiency protect against cancer? A critical review.
Cocco, P. (1987) · Journal of Epidemiology & Community Health · doi:10.1136/jech.41.2.89 · Cited by 39 · see citing works
Self-citationFeo, F., Pirisi, L. A., Pascale, R. M., Daino, L., Frassetto, S., Garcea, R., & Gaspa, L. (1984) · PubMed · Cited by 35 · see citing works
Acinar Cell Carcinoma of Rat Pancreas: Mechanism of Deregulation of Cholesterol Metabolism
Rao, K. N., Kottapally, S., & Shinozuka, H. (1984) · Toxicologic Pathology · doi:10.1177/019262338401200110 · Cited by 33 · see citing works
Dessı̀, S., Batetta, B., Cherchi, R. M., Onnis, R., Pisano, M., & Pani, P. (2009) · Oncology · doi:10.1159/000226624 · Cited by 29 · see citing works
Self-citationChanges in Serum and Hepatic Cholesterol in Lead-Induced Liver Hyperplasia
Pani, P., Dessı̀, S., Rao, K. N., Batetta, B., & Laconi, E. (1984) · Toxicologic Pathology · doi:10.1177/019262338401200208 · Cited by 29 · see citing works
The Association between Glucose-6-Phosphate Dehydrogenase Deficiency and Cancer in American Negroes
Naik, S. N., & Anderson, D. (2009) · Oncology · doi:10.1159/000224585 · Cited by 24 · see citing works
Cocco, P., Dessı̀, S., Avataneo, G., Picchiri, G., & Heinemann, E. (1989) · Carcinogenesis · doi:10.1093/carcin/10.5.813 · Cited by 24 · see citing works
Self-citationGlucose 6-phosphate dehydrogenase deficiency and incidence of hematologic malignancy.
Ferraris, A., Broccia, G., Meloni, T., Forteleoni, G., & Gaetani, G. F. (1988) · Europe PMC (PubMed Central) · Cited by 22 · see citing works
Hexose monophosphate shunt and cholesterol synthesis in the diabetic and fasting states
Dessı̀, S., Chiodino, C., Batetta, B., Laconi, E., Ennas, C., & Pani, P. (1985) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(85)90038-3 · Cited by 18 · see citing works
Preliminary Results of a Geographic Correlation Study on G6PD Deficiency and Cancer
Cocco, P., Manca, P., & Dessı̀, S. (1987) · Toxicologic Pathology · doi:10.1177/019262338701500116 · Cited by 18 · see citing works
Self-citationGlucose-6-Phosphate Dehydrogenase Deficiency in Italy
SALVIDIO, E., Pannacciulli, I. M., TIZIANELLO, A., Gaetani, G. F., & Gf, P. (2009) · Acta Haematologica · doi:10.1159/000208870 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233 · see citing works
Metabolic targets for cancer therapy
Galluzzi, L., Kepp, O., Heiden, M. G. V., & Kroemer, G. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4145 · Cited by 705 · see citing works
Targeting cancer metabolism – aiming at a tumour's sweet-spot
Jones, N. P., & Schulze, A. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.12.017 · Cited by 162 · see citing works
Ho, H., Cheng, M., & Chiu, D. T.-Y. (2007) · Redox Report · doi:10.1179/135100007x200209 · Cited by 152 · see citing works
Overexpression of G6PD is associated with poor clinical outcome in gastric cancer
Wang, J., 袁伟杰, Chen, Z., Wu, S., 陈晋湘, Ge, J., Hou, F., & Chen, Z. (2011) · Tumor Biology · doi:10.1007/s13277-011-0251-9 · Cited by 126 · see citing works
Mortality in a Cohort of Men Expressing the Glucose-6-Phosphate Dehydrogenase Deficiency
Cocco, P., Todde, P., Fornera, S., Bonaria Manca, M., Manca, P., & Rosa Sias, A. (1998) · Blood · doi:10.1182/blood.v91.2.706 · Cited by 112 · see citing works
Self-citationThe Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH
Alfarouk, K. O., Ahmed, S. B. M., Elliott, R. L., Benoit, A., Alqahtani, S. S., Ibrahim, M. E., Bashir, A. H. H., Alhoufie, S. T. S., Elhassan, G. O., Wales, C. C., et al. (2020) · Metabolites · doi:10.3390/metabo10070285 · Cited by 104 · see citing works
Glucose-6-phosphate dehydrogenase – beyond the realm of red cell biology
Ho, H., Cheng, M.-L., & Chiu, D. T.-Y. (2014) · Free Radical Research · doi:10.3109/10715762.2014.913788 · Cited by 41 · see citing works
Glucose-6-phosphate dehydrogenase deficiency reduces susceptibility to cancer of endodermal origin
Pes, G. M., Errigo, A., Soro, S., Longo, N. P., & Dore, M. P. (2019) · Acta Oncologica · doi:10.1080/0284186x.2019.1616815 · Cited by 34 · see citing works
G6PD--an old bottle with new wine.
Ho, H., Cheng, M., & Chiu, D. T.-Y. (2005) · PubMed · Cited by 27 · see citing works
He, C., Yang, J., Ding, J., Li, S., Wu, H. M., Xiong, Y., Zhou, F., Jiang, Y.-R., Teng, L., & Yang, J. (2018) · Oncology Reports · doi:10.3892/or.2018.6755 · Cited by 22 · see citing works
You, H., You, N., Lee, J., Lim, H.-J., Kim, J., & Kang, H. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17031054 · Cited by 18 · see citing works
MOLECULAR BASIS OF G6PD DEFICIENCY: CURRENT STATUS AND ITS PERSPECTIVE
Dalouei, M. R. N., & Maryam, D. P. (2008) · ACTA MEDICA IRANICA · Cited by 7 · see citing works
Biosynthesis of Ribose-5-Phosphate—Metabolic Regulator of Escherichia coli Viability
Seregina, T. A., Shakulov, R. S., Petrushanko, I. Y., Lobanov, K. V., & Mironov, A. S. (2025) · Cells · doi:10.3390/cells14221775 · Cited by 5 · see citing works
Mortality of lead smelter workers with the glucose-6-phosphate dehydrogenase-deficient phenotype.
Cocco, P., Carta, P., Flore, C., Congia, P., Manca, M. B., Saba, G. J., & Salis, S. (1996) · PubMed · Cited by 5 · see citing works
Self-citationCase-Control Studies on Cancer Risk in G6PD-Deficient Male Populations
Cocco, P. L., Dessı̀, S., Manca, P., Cherchi, R. M., Pisano, M., & Todde, P. (1991) · Springer eBooks · doi:10.1007/978-1-4615-3694-9_15
Self-citationInfluence of Pyruvate Kinase Isoform Expression on Primary Cell Proliferation and Metabolism
Muralidhar, V. (2016) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
- Authors
- Pisano, M., Cocco, P., Cherchi, R., Onnis, R., & Cherchi, P.
- Affiliations
- Divisione di Chirurgia Toracica, Ospedale Binaghi, Usl 20 Cagliari
- University of Cagliari (IT)
- Ministère De La Santé (BF)
- ORCID
- Cocco, Pierluigi
- Venue
- Tumori Journal
- Publisher
- SAGE Publications
- Published
- 1991-02
- Volume
- 77
- Issue
- 1
- Pages
- 12-15
- ISSN
- 0300-8916 (ISSN-L)
- 2038-2529
- OpenAlex
- W4661696
- Cited by
- 17
- References
- 23
- Citations by year
- 2025: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Tumori Journal (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- glucose-6-phosphate dehydrogenase deficiency, lung cancer, cancer risk, genetic susceptibility, hemolytic anemia, protective effect
- MeSH terms
- Adult, Age Factors, Carcinoma, Squamous Cell, Glucosephosphate Dehydrogenase Deficiency, Humans, Lung Neoplasms, Male, Middle Aged, Risk Factors, Smoking, Case-Control Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
