Quality of life impairment, disability and economic burden associated with chronic daily headache, focusing on chronic migraine with or without medication overuse: A systematic review
Abstract
Objective: To evaluate the evidence for quality of life (QoL) impairment, disability, healthcare resource use and economic burden associated with chronic daily headache (CDH), focusing on chronic migraine (CM) with or without medication overuse. Methods: A systematic review and qualitative synthesis of studies of patients/subjects with CDH that included CM, occurring on at least 15 days per month. Main findings: Thirty-four studies were included for review (25 studies of patients and nine of subjects from the general population). CDH and CDH with medication overuse headache (MOH) were consistently associated with a lower QoL compared to control or episodic headache (EH) and CDH without MOH. CDH was consistently associated with greater disability and productivity loss, more consultations, more or longer hospitalizations and higher direct costs than EH. Data were not amenable to statistical pooling. Principal conclusions: The findings of this review underline the detriment to QoL and the disabling nature of CDH, and in particular CM and CDH with MOH, and negative impact on workplace productivity compared to other types of headache.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Medication overuse headache treatment has few evidence-based indications.
“Medication overuse headache (MOH) is a severe burden to sufferers and its treatment has few evidence-based indications.”
From Nabilone for the treatment of medication overuse headache: results of a preliminary double-blind, active-controlled, randomized trial (2012) · cites this paper as [7]
In these patients, the main unresolved problem is excessive use of drugs for acute treatment and overall deterioration in quality of life, so headache symptoms should be considered as part of the issue as a whole.
“In these patients, the main unresolved problem is the excessive use of drugs for the acute treatment and the overall deterioration experienced in their quality of life, so the headache symptoms should be considered as part of the issue as a whole [2, 6, 7].”
From Nabilone for the treatment of medication overuse headache: results of a preliminary double-blind, active-controlled, randomized trial (2012) · cites this paper as [7]
Cites
(1992) · PubMed · Cited by 33,716 · see citing works
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033 · see citing works
The International Classification of Headache Disorders: 2nd edition
Olesen, J., Goadsby, P. J., & Steiner, T. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00590-8 · Cited by 5,046 · see citing works
Christakis, D., Richards, J. A., Zimmerman, F. J., Garrison, M. M., Xu, D., & Yapanel, U. H. (2009) · Cited by 2,290 · see citing works
New Appendix Criteria Open for a Broader Concept of Chronic Migraine
Olesen, J., Bousser, M.-G., Diener, H.-C., Dodick, D., First, M., Goadsby, P., Göbel, H., Lainez, M., Lance, J., Lipton, R., et al. (2006) · Cephalalgia · doi:10.1111/j.1468-2982.2006.01172.x · Cited by 909 · see citing works
Epidemiology of Chronic Daily Headache in the General Population
Castillo, J., Muñoz, P., Guitera, V., & Pascual, J. (1999) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.1999.3903190.x · Cited by 711 · see citing works
Classification of daily and near-daily headaches
Silberstein, S. D., Lipton, R. B., & Sliwinski, M. J. (1996) · Neurology · doi:10.1212/wnl.47.4.871 · Cited by 613 · see citing works
Prevalence of Frequent Headache in a Population Sample
Scher, I., Stewart, W. F., Liberman, J. N., & Lipton, R. B. (1998) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.1998.3807497.x · Cited by 604 · see citing works
Wolff’s Headache and Other Head Pain
(2009) · Archives of Neurology · doi:10.1001/archneurol.2009.17 · Cited by 588 · see citing works
Chronic migraine in the population
BIGAL, M. E., Serrano, D., Reed, M. L., & Lipton, R. B. (2008) · Neurology · doi:10.1212/01.wnl.0000323925.29520.e7 · Cited by 488 · see citing works
Classification of Daily and Near‐Daily Headaches: Proposed Revisions to the IHS Criteria
Silberstein, S. D., Lipton, R. B., Solomon, S., & Mathew, N. T. (1994) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.1994.hed3401001.x · Cited by 432 · see citing works
Depression and functional disability in chronic pediatric pain
Kashikar-Zuck, S., Goldschneider, K. R., Powers, S. W., Vaught, M. H., & Hershey, A. D. (2001) · The Clinical Journal of Pain · doi:10.1097/00002508-200112000-00009 · Cited by 357 · see citing works
Munakata, J., Hazard, E., Serrano, D., Klingman, D., Rupnow, M. F. T., Tierce, J. C., Reed, M. L., & Lipton, R. B. (2009) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2009.01369.x · Cited by 298 · see citing works
Chronic daily headache in Chinese elderly
Wang, S.-J., Fuh, J., Lu, S. ‐., Liu, C. Y., Hsu, L., Wang, P.-N., & Liu, H.-C. (2000) · Neurology · doi:10.1212/wnl.54.2.314 · Cited by 270 · see citing works
Chronic Daily Headache in Taipei, Taiwan: Prevalence, Follow-Up and Outcome Predictors
Lu, S., Fuh, J., Chen, W., Juang, K., & Wang, S.-J. (2001) · Cephalalgia · doi:10.1046/j.1468-2982.2001.00294.x · Cited by 253 · see citing works
BIGAL, M. E., Rapoport, A. M., Lipton, R. B., Tepper, S. J., & Sheftell, F. D. (2003) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2003.03068.x · Cited by 242 · see citing works
Prevalence and description of chronic daily headache in the general population in France
Lantéri‐Minet, M., Auray, J., Hasnaoui, A. E., Dartigues, J., Duru, G., Henry, P., Lucas, C., Pradalier, A., Chazot, G., & Gaudin, A.-F. (2003) · Pain · doi:10.1016/s0304-3959(02)00348-2 · Cited by 211 · see citing works
Self-citationQuality of life differs among headache diagnoses: analysis of SF-36 survey in 901 headache patients
Wang, S., Fuh, J., Lu, S., & Juang, K. (2001) · Pain · doi:10.1016/s0304-3959(00)00380-8 · Cited by 185 · see citing works
Quality‐of‐Life Differences Between Patients With Episodic and Transformed Migraine
Meletiche, D. M., Lofland, J. H., & Young, W. B. (2001) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2001.041006573.x · Cited by 165 · see citing works
Quality of life in chronic daily headache
Guitera, V., Muñoz, P., Castillo, J., & Pascual, J. (2002) · Neurology · doi:10.1212/wnl.58.7.1062 · Cited by 160 · see citing works
Quality of life in migraine and chronic daily headache patients.
Monzón, M. J., & Láinez, M. J. A. (1998) · PubMed · doi:10.1111/j.1468-2982.1998.1809638.x · Cited by 114 · see citing works
Long-Term Follow-Up of Patients Treated for Chronic Headache with Analgesic Overuse
Pini, L.-A., Cicero, A., & Sandrini, M. (2001) · Cephalalgia · doi:10.1046/j.1468-2982.2001.00288.x · Cited by 95 · see citing works
Use of the Emergency Department for Severe Headache. A Population‐Based Study
Friedman, B. W., Serrano, D., Reed, M. L., Diamond, M. L., & Lipton, R. B. (2008) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2008.01282.x · Cited by 89 · see citing works
Quality of life and disability in primary chronic daily headaches
D’Amico, D., Usai, S., Grazzi, L., et al. (2003) · Neurological Sciences · doi:10.1007/s100720300052 · Cited by 83 · see citing works
Disability and quality of life in different primary headaches: results from Italian studies
Bussone, G., Usai, S., Grazzi, L., Rigamonti, A., Solari, A., & D’Amico, D. (2004) · Neurological Sciences · doi:10.1007/s10072-004-0263-y · Cited by 78 · see citing works
Chronic daily headache in adolescents
Wang, S., Fuh, J., & Lu, S. (2009) · Neurology · doi:10.1212/wnl.0b013e3181ae2377 · Cited by 75 · see citing works
Emotional Problems and Prevalence of Medication Overuse in Pediatric Chronic Daily Headache
Pakalnis, A., Butz, C., Splaingard, D., Kring, D., & Fong, J. S. (2007) · Journal of Child Neurology · doi:10.1177/0883073807307090 · Cited by 64 · see citing works
Rossi, P. D., Lorenzo, G. D., Malpezzi, M. G., Lorenzo, C. D., Cesarino, F., Faroni, J., Siracusano, A., & Troisi, A. (2005) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2005.05110.x · Cited by 62 · see citing works
Impact of Headache on Quality of Life in a General Population Survey in France (GRIM2000 Study)
Duru, G., Auray, J., Gaudin, A.-F., Dartigues, J., Henry, P., Lantéri‐Minet, M., Lucas, C., Pradalier, A., Chazot, G., & Hasnaoui, A. E. (2004) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2004.446005.x · Cited by 61 · see citing works
Self-citationCoping Styles of Headache Sufferers
Siniatchkin, M., Riabus, M. V., & Hasenbring, M. I. (1999) · Cephalalgia · doi:10.1046/j.1468-2982.1999.1903165.x · Cited by 60 · see citing works
Factors Associated With Burden of Primary Headache in a Specialty Clinic
Cassidy, E., Tomkins, E., Hardiman, O. M., & O’Keane, V. (2003) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2003.03106.x · Cited by 60 · see citing works
D’Amico, D., Grazzi, L., Usai, S., Rigamonti, A., Curone, M., & Bussone, G. (2005) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2005.05109.x · Cited by 54 · see citing works
Prognostic Significance of Personality Profiles in Patients With Chronic Migraine
Luconi, R., Bartolini, M., Taffi, R., Vignini, A., Mazzanti, L., Provinciali, L., & Silvestrini, M. (2007) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2007.00807.x · Cited by 50 · see citing works
Effectiveness of a Multidisciplinary Treatment Program for Chronic Daily Headache
Magnusson, J. E., Riess, C. M., & Becker, W. J. (2004) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100002869 · Cited by 47 · see citing works
Grazzi, L., Andrasik, F., D’Amico, D., Usai, S., Kass, S. J., & Bussone, G. (2004) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2004.04127.x · Cited by 45 · see citing works
Sun‐Edelstein, C., Bigal, M., & Rapoport, A. M. (2009) · Cephalalgia · doi:10.1111/j.1468-2982.2008.01753.x · Cited by 44 · see citing works
Filippis, S. D., Erbuto, D., Gentili, F., Innamorati, M., Lester, D., Tatarelli, R., Martelletti, P., & Pompili, M. (2008) · The Journal of Headache and Pain · doi:10.1007/s10194-008-0072-4 · Cited by 38 · see citing works
Sick Leave is Related to Frequencies of Migraine and Non-Migrainous Headache—The HUNT Study
Fiane, I., Haugland, M., Stovner, L., Zwart, J.-A., Bovim, G., & Hagen, K. (2006) · Cephalalgia · doi:10.1111/j.1468-2982.2006.01151.x · Cited by 37 · see citing works
Primary headaches in an outpatient neurology headache clinic in East Hungary
Gesztelyi, G., & Bereczki, D. (2004) · European Journal of Neurology · doi:10.1111/j.1468-1331.2004.00800.x · Cited by 37 · see citing works
Disability in Chronic Migraine With Medication Overuse: Treatment Effects at 3 Years
Andrasik, F., Grazzi, L., Usai, S., D’Amico, D., Kass, S. J., & Bussone, G. (2007) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2007.00861.x · Cited by 33 · see citing works
Phobias, other psychiatric comorbidities and chronic migraine
Corchs, F., Mercante, J. P. P., Guendler, V. Z., Vieira, D. S., Masruha, M. R., Moreira, F. R., Bernik, M., Zukerman, E., & Peres, M. F. P. (2006) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2006000600012 · Cited by 27 · see citing works
Economic impact of primary headaches in Turkey: a university hospital based study: part II
Karlı, N., Zarifoğlu, M., Ertafş, M., et al. (2006) · The Journal of Headache and Pain · doi:10.1007/s10194-006-0273-7 · Cited by 26 · see citing works
Psychiatric morbidity and cognitive representations of illness in chronic daily headache
Page, L., Howard, L. M., Husain, K., Tong, J., Dowson, A., Weinman, J. A., & Wessely, S. C. (2004) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2004.04.371 · Cited by 22 · see citing works
Cost assessment of headache in childhood and adolescence: preliminary data
Mazzotta, G. M., Gallai, B., Mattioni, A., et al. (2005) · The Journal of Headache and Pain · doi:10.1007/s10194-005-0207-9 · Cited by 21 · see citing works
Chronic daily headache: stress and impact on the quality of life
Galego, J. C. B., Moraes, A. M., Cordeiro, J. A., & Tognola, W. A. (2007) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2007000700006 · Cited by 20 · see citing works
Tenhunen, K., & Elander, J. (2005) · Journal of Health Psychology · doi:10.1177/1359105305051425 · Cited by 18 · see citing works
Comorbidade psiquiátrica diminui a qualidade de vida de pacientes com enxaqueca crônica
Mercante, J. P. P., Bernik, M., Zukerman-Guendler, V., et al. (2007) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2007000500031 · Cited by 17 · see citing works
Psychosocial aspects of chronic daily headache
Barton-Donovan, L. K., & Blanchard, E. B. (2005) · The Journal of Headache and Pain · doi:10.1007/s10194-005-0147-4 · Cited by 16 · see citing works
Perceived Headache Associations in Singapore. Results of a Randomized National Survey
Ho, K., & Benjamin, K. C. O. (2001) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2001.111006164.x · Cited by 12 · see citing works
Coeytaux, R. R., & Spierings, E. (2005) · Cephalalgia · doi:10.1111/j.1468-2982.2005.00976.x · Cited by 9 · see citing works
Lafittau, M., Radat, F., Irachabal, S., & Créac’h, C. (2006) · L Encéphale · doi:10.1016/s0013-7006(06)76149-8 · Cited by 8 · see citing works
Disability in migraine patients: Italian experience
Bussone, G., Grazzi, L., Usai, S., et al. (2001) · The Journal of Headache and Pain · doi:10.1007/s101940170006 · Cited by 5 · see citing works
Quality of life and illness behaviour in chronic daily headache patients
Prudenzano, M. P., Guazzelli, M., Verri, A. P., et al. (2000) · The Journal of Headache and Pain · doi:10.1007/s101940070029 · Cited by 3 · see citing works
Chronic daily headache: classification, stress and impact on the quality of life
Galego, J. C. B. (2006) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2006000500036 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pini, L. A., Guerzoni, S., Cainazzo, M. M., Ferrari, A., Sarchielli, P., Tiraferri, I., Ciccarese, M., & Zappaterra, M. (2012) · The Journal of Headache and Pain · doi:10.1007/s10194-012-0490-1 · Cited by 107 · see citing works
Nichols, V. P., Ellard, D. R., Griffiths, F. E., Kamal, A., Underwood, M., & Taylor, S. J. C. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-019929 · Cited by 73 · see citing works
Multidisciplinary integrated headache care: a prospective 12-month follow-up observational study
Wallasch, T.-M., & Kropp, P. (2012) · The Journal of Headache and Pain · doi:10.1007/s10194-012-0469-y · Cited by 69 · see citing works
Gibbs, S. N., Shah, S., Deshpande, C. G., Bensink, M. E., Broder, M. S., Dumas, P. K., Buse, D. C., Vo, P., & Schwedt, T. J. (2020) · Headache: The Journal of Head and Face Pain · doi:10.1111/head.13829 · Cited by 50 · see citing works
Steiner, T. J., Terwindt, G. M., Katsarava, Z., Pozo-Rosich, P., Gantenbein, A. R., Roche, S. L., Dell’Agnello, G., & Tassorelli, C. (2022) · Cephalalgia · doi:10.1177/03331024221110102 · Cited by 39 · see citing works
Graef, J. E., Rief, W., French, D. J., Nilges, P., & Nestoriuc, Y. (2015) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12564 · Cited by 18 · see citing works
Khazraee, H., Bakhtiari, M., Kianimoghadam, A. S., & Hajmanouchehri, R. (2023) · Life · doi:10.3390/life13010131 · Cited by 13 · see citing works
- Authors
- Lantéri-Minet, M., Duru, G., Mudge, M., & Cottrell, S.
- Affiliations
- CHU de Nice – Hôpital Pasteur, France.
- Lyon 1 Université (FR)
- THEMA Consulting Pty Ltd, Australia.
- Venue
- Cephalalgia
- Publisher
- SAGE Publications
- Published
- 2011-04-04
- Volume
- 31
- Issue
- 7
- Pages
- 837-850
- ISSN
- 0333-1024 (ISSN-L)
- 1468-2982
- OpenAlex
- W1982183874
- Cited by
- 303
- References
- 54
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 22 · 2023: 26 · 2022: 23 · 2021: 27 · 2020: 23 · 2019: 15 · 2018: 22 · 2017: 16 · 2016: 12 · 2015: 26 · 2014: 23 · 2013: 20 · 2012: 13
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cephalalgia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- chronic daily headache, chronic migraine, medication overuse headache, quality of life, disability, productivity loss, health care utilization, economic burden, direct costs, hospitalization, episodic headache
- MeSH terms
- Analgesics, Chronic Disease, Humans, Migraine Disorders, Quality of Life, Cost of Illness, Headache Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
