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Cited by 374

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Tenocytes from Ruptured and Tendinopathic Achilles Tendons Produce Greater Quantities of Type III Collagen than Tenocytes from Normal Achilles Tendons: An in Vitro Model of Human Tendon Healing

Maffulli, Nicola, Ewen, Stanley W. B., Waterston, Stuart W., Reaper, Jacqueline, Barrass, Victoria·2000·The American Journal of Sports Medicine
DOI 10.1177/03635465000280040901
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Abstract

Type I collagen is the main collagen in tendons; type III collagen is present in small amounts. Ruptured Achilles tendons contain a significantly greater proportion of type III collagen, which predisposes them to rupture. We used an in vitro model to determine whether tenocytes from Achilles tendons that were ruptured (N 22), nonruptured (N 7), tendinopathic (N 12), and fetal (N 8) show different behavior. Samples of Achilles tendon were digested with collagenase and the released tenocytes were collected. Primary tenocyte cultures were established and subsequently cultured onto glass coverslips. Once a confluent monolayer was obtained, the cell populations were “wounded” by scraping a pipette tip along the surface. The cultures were further incubated for either 1, 4, 8, 12, 16, or 24 hours, and production of types I and II collagen was assessed by immunostaining. In cultures from ruptured and tendinopathic tendons, there was increased production of type III collagen. Athletic participation places excess stress on the Achilles tendon, which could potentially lead to areas of microtrauma within the tendon. These areas may heal by the production of type III collagen, which is an abnormal healing response. Accumulation of such episodes of microtrauma could result in a critical point where the resistance of the tissue to tensile forces is compromised and tendon rupture occurs.

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Metadata

Authors
Maffulli, N., Ewen, S. W. B., Waterston, S. W., Reaper, J., & Barrass, V.
Venue
The American Journal of Sports Medicine
Publisher
SAGE Publications
Published
2000-07
Volume
28
Issue
4
Pages
499-505
ISSN
  • 0363-5465 (ISSN-L)
  • 1552-3365
DOI
10.1177/03635465000280040901
OpenAlex
W1921978279
Cited by
374
References
15
FWCI
6.51
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Tenocytes from Ruptured and Tendinopathic Achilles Tendons Produce Greater Quantities of Type III Collagen than Tenocytes from Normal Achilles Tendons: An in Vitro Model of Human Tendon Healing. https://app.cochat.ai/papers/10.1177/03635465000280040901
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Maffulli, N., Ewen, S. W. B., Waterston, S. W., Reaper, J., & Barrass, V. (2000). Tenocytes from Ruptured and Tendinopathic Achilles Tendons Produce Greater Quantities of Type III Collagen than Tenocytes from Normal Achilles Tendons: An in Vitro Model of Human Tendon Healing. The American Journal of Sports Medicine. https://doi.org/10.1177/03635465000280040901

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.