The Effects of Augmentation with Swine Small Intestine Submucosa on Tendon Healing under Tension: Histologic and Mechanical Evaluations in Sheep
Abstract
Background: Rotator cuff failure after surgery may be attributed to inferior tissue healing properties that result from repetitive cyclic loading during early rehabilitation. Enhancing the biological healing process may reduce the incidence of failures after rotator cuff repairs. Hypothesis: Augmentation of rotator cuff tissue using swine small intestine submucosa in a sheep model will improve the rate and quality of tissue repair. Study Design: Controlled laboratory study. Methods: We resected and reattached 26 sheep infraspinatus tendons under tension, with 13 animals receiving a small intestine submucosa patch (augmented group). Animals were sacrificed at 12 weeks, and biomechanical testing and histologic evaluation were performed. Biomechanical testing was completed in 10 tendons from each group. Specimens were loaded to failure at a constant displacement to obtain the load deformation curve used to calculate load to failure and stiffness of the healed bone-tendon interface. Histologic testing addressed tissue healing at the bone-tendon interface. Results: The load-to-failure data did not indicate a significant difference between the augmented and nonaugmented groups (1252 ± 402 N vs 985 ± 459 N, respectively; P >. 05). However, the augmented group had significantly better stiffness than the nonaugmented group (215 ± 44 N/mm vs 154 ± 63 N/mm, respectively; P =. 03). Histologic data revealed that the infraspinatus tendon in all specimens inserted into the bone through a zone of fibrocartilage, although none of the patches were intact. Conclusion: Although there were no differences in the load-to-failure data between the 2 groups, the statistically significant improvement in stiffness for the augmented group is clinically relevant. Stiffness is the biomechanical parameter representing the tissue response to subdestructive loads seen with early rehabilitation. Augmenting the repair with a collagen matrix improved the early healing characteristics of the repair construct. Clinical Relevance: Enhancing the biological process of tendon healing under tension by using a collagen matrix patch may improve the ultimate success of rotator cuff repair.
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Cites
Galatz, L. M., Ball, C. M., Teefey, S. A., Middleton, W. D., & Yamaguchi, K. (2004) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200402000-00002 · Cited by 2,144 · see citing works
Repairs of the rotator cuff. Correlation of functional results with integrity of the cuff.
Harryman, D. T., Mack, L. A., Wang, K. Y., Jackins, S. E., Richardson, M. L., & Matsen, F. A. (1991) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199173070-00004 · Cited by 1,255 · see citing works
Results of a second attempt at surgical repair of a failed initial rotator-cuff repair.
DeOrio, J. K., & Cofield, R. H. (1984) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-198466040-00011 · Cited by 925 · see citing works
Mechanical strength of repairs of the rotator cuff
Gerber, C., Schneeberger, A. G., Beck, M., & Schlegel, U. J. (1994) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.76b3.8175836 · Cited by 689 · see citing works
Functional and Anatomical Results After Rotator Cuff Repair
Gazielly, D. F., Gleyze, P., & Montagnon, C. (1994) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199407000-00009 · Cited by 552 · see citing works
Experimental Rotator Cuff Repair. A Preliminary Study*
Gerber, C., Schneeberger, A. G., Perren, S. M., & Nyffeler, R. W. (1999) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199909000-00009 · Cited by 464 · see citing works
Gartsman, G. M. (1997) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199705000-00011 · Cited by 284 · see citing works
Tissue-Engineered Rotator Cuff Tendon Using Porcine Small Intestine Submucosa
Déjardin, L. M., ARNOCZKY, S. P., Ewers, B. J., Haut, R. C., & Clarke, R. B. (2001) · The American Journal of Sports Medicine · doi:10.1177/03635465010290021001 · Cited by 275 · see citing works
Repair of Full Thickness Rotator Cuff Tears Gender, Age, and Other Factors Affecting Outcome
Romeo, A. A., Hang, D. W., Bach, B. R., & Shott, S. (1999) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199910000-00031 · Cited by 253 · see citing works
Cyclic loading of transosseous rotator cuff repairs: Tension overload as a possible cause of failure
Burkhart, S. S., Johnson, T. C., Wirth, M. A., & Athanasiou, K. A. (1997) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/s0749-8063(97)90151-1 · Cited by 252 · see citing works
The Joint Side Tear of the Rotator Cuff
Yamanaka, K., & Matsurnoto, T. (1994) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199407000-00012 · Cited by 238 · see citing works
Rotator cuff repair: Relevance of patient age
Hattrup, S. J., & Ariz, S. (1995) · Journal of Shoulder and Elbow Surgery · doi:10.1016/s1058-2746(05)80061-8 · Cited by 138 · see citing works
Strength after surgical repair of the rotator cuff
Rokito, A. S., Zuckerman, J. D., Gallagher, M., & Cuomo, F. (1996) · Journal of Shoulder and Elbow Surgery · doi:10.1016/s1058-2746(96)80025-5 · Cited by 137 · see citing works
Biomechanical evaluation of rotator cuff fixation methods
France, E. P., Paulos, L. E., Harner, C. D., & Straight, C. B. (1989) · The American Journal of Sports Medicine · doi:10.1177/036354658901700206 · Cited by 94 · see citing works
Mechanical factors in the initiation and propagation of tears of the rotator cuff
Reilly, P., Amis, A. A., Wallace, A. L., & Emery, R. J. (2003) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.85b4.12062 · Cited by 93 · see citing works
Lewis, C. W., Schlegel, T. F., Hawkins, R. J., James, S. P., & Turner, A. S. (2001) · PubMed · Cited by 64 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690 · see citing works
Novel Nanofiber-Based Scaffold for Rotator Cuff Repair and Augmentation
Moffat, K. L., Kwei, A. S.-P., Spalazzi, J. P., Doty, S. B., Levine, W. N., & Lu, H. H. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0014 · Cited by 307 · see citing works
Rodeo, S. A., Potter, H. G., Kawamura, S., Turner, A. S., Kim, H. J., & Atkinson, B. L. (2007) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200711000-00021 · Cited by 292 · see citing works
Self-citationTendon augmentation grafts: a systematic review
Longo, U. G., Lamberti, A., Maffulli, N., & Denaro, V. (2010) · British Medical Bulletin · doi:10.1093/bmb/ldp051 · Cited by 280 · see citing works
Biological Augmentation of Rotator Cuff Tendon Repair
Kovacevic, D., & Rodeo, S. A. (2008) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-007-0112-4 · Cited by 278 · see citing works
Scaffold devices for rotator cuff repair
Ricchetti, E. T., Aurora, A., Iannotti, J. P., & Derwin, K. A. (2012) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2011.10.003 · Cited by 211 · see citing works
Ciampi, P., Scotti, C., Nonis, A., Vitali, M., Serio, C. D., Peretti, G. M., & Fraschini, G. (2014) · The American Journal of Sports Medicine · doi:10.1177/0363546514525592 · Cited by 211 · see citing works
Extracellular matrix scaffold devices for rotator cuff repair
Derwin, K. A., Badylak, S. F., Steinmann, S. P., & Iannotti, J. P. (2010) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2009.10.020 · Cited by 205 · see citing works
Aurora, A., McCarron, J. A., Iannotti, J. P., & Derwin, K. A. (2007) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2007.03.008 · Cited by 173 · see citing works
Iván Encalada-Díaz, M., Cole, B. J., MacGillivray, J. D., Ruiz‐Suarez, M., Kercher, J. S., Friel, N. A., & González, F. S. (2010) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2010.08.013 · Cited by 168 · see citing works
Platelet Rich Plasma in Rotator Cuff Repair
Gamradt, S. C., Rodeo, S. A., & Warren, R. F. (2007) · Techniques in Orthopaedics · doi:10.1097/01.bto.0000261868.03232.dd · Cited by 164 · see citing works
Management of massive and irreparable rotator cuff tears
Neri, B. R., Chan, K. W., & Kwon, Y. W. (2009) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2009.03.013 · Cited by 164 · see citing works
Rotator Cuff Repair Augmentation in a Canine Model with Use of a Woven Poly-L-Lactide Device
Derwin, K. A., Codsi, M. J., Milks, R. A., Baker, A. R., McCarron, J. A., & Iannotti, J. P. (2009) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.h.00775 · Cited by 161 · see citing works
Biologic augmentation of rotator cuff tendon repair
Rodeo, S. A. (2007) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2007.03.012 · Cited by 159 · see citing works
Yin, Z., Hu, J., Yang, L., Zheng, Z., An, C., Wu, B., Zhang, C., Shen, W., Liu, H., Chen, J., et al. (2016) · Science Advances · doi:10.1126/sciadv.1600874 · Cited by 148 · see citing works
Hee, C. K., Dines, J. S., Dines, D. M., Roden, C. M., Wisner-Lynch, L., Turner, A. S., McGilvray, K. C., Lyons, A. S., Puttlitz, C. M., & Santoni, B. G. (2011) · The American Journal of Sports Medicine · doi:10.1177/0363546511404942 · Cited by 144 · see citing works
Self-citationBiomimetic scaffold design for functional and integrative tendon repair
Zhang, X., Bogdanowicz, D. R., Erişken, C., Lee, N. M., & Lu, H. H. (2012) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2011.11.016 · Cited by 133 · see citing works
Use of Graft Jacket as an Augmentation for Massive Rotator Cuff Tears
Burkhead, W. Z., Schiffern, S. C., & Krishnan, S. G. (2007) · Seminars in Arthroplasty JSES · doi:10.1053/j.sart.2006.11.017 · Cited by 127 · see citing works
Gilot, G. J., Alvarez-Pinzon, A. M., Barcksdale, L., Westerdahl, D., Krill, M. K., & Peck, E. (2015) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2015.02.032 · Cited by 123 · see citing works
Cytokines in rotator cuff degeneration and repair
Bedi, A., Maak, T. G., Walsh, C. P., Rodeo, S. A., Grande, D., Dines, D. M., & Dines, J. S. (2012) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2011.09.020 · Cited by 119 · see citing works
Outcomes After Patch Use in Rotator Cuff Repair
Steinhaus, M. E., Makhni, E. C., Cole, B. J., Romeo, A. A., & Verma, N. N. (2016) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2016.02.009 · Cited by 116 · see citing works
Biomaterials strategies to balance inflammation and tenogenesis for tendon repair
Hou, J., Yang, R., Vuong, I., Li, F., Kong, J., & Mao, H. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.05.043 · Cited by 110 · see citing works
Preclinical Models for Translating Regenerative Medicine Therapies for Rotator Cuff Repair
Derwin, K. A., Baker, A. R., Iannotti, J. P., & McCarron, J. A. (2009) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2009.0209 · Cited by 109 · see citing works
Experiences with sheep as an animal model for shoulder surgery: Strengths and shortcomings
Turner, A. S. (2007) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2007.03.002 · Cited by 108 · see citing works
Self-citationSantoni, B. G., McGilvray, K. C., Lyons, A. S., Bansal, M., Turner, A. S., MacGillivray, J. D., Coleman, S. H., & Puttlitz, C. M. (2010) · The American Journal of Sports Medicine · doi:10.1177/0363546510366866 · Cited by 99 · see citing works
Self-citationChung, S. W., Song, B. W., Kim, Y. H., Park, K. U., & Oh, J. H. (2013) · The American Journal of Sports Medicine · doi:10.1177/0363546513503810 · Cited by 95 · see citing works
Decellularized and Engineered Tendons as Biological Substitutes: A Critical Review
Lovati, A. B., Bottagisio, M., & Moretti, M. (2016) · Stem Cells International · doi:10.1155/2016/7276150 · Cited by 93 · see citing works
Chaturvedi, L. S., Marsh, H. W., Shang, X., Zheng, Y., & Basson, M. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605817200 · Cited by 80 · see citing works
Rotator cuff tears: pathology and repair
Yadav, H., Nho, S. J., Romeo, A. A., & MacGillivray, J. D. (2008) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-008-0686-8 · Cited by 79 · see citing works
McCarron, J. A., Milks, R. A., Chen, X., Iannotti, J. P., & Derwin, K. A. (2010) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2009.12.008 · Cited by 77 · see citing works
ARNOCZKY, S. P., Bishai, S. K., Schofield, B., Sigman, S. A., Bushnell, B. D., Hommen, J. P., & Kampen, C. L. V. (2016) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2016.06.047 · Cited by 76 · see citing works
Shea, K. P., Obopilwe, E., Sperling, J. W., & Iannotti, J. P. (2011) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2011.07.024 · Cited by 75 · see citing works
Rotator cuff tears: what have we learned from animal models?
Edelstein, L., Thomas, S. J., & Soslowsky, L. J. (2011) · PubMed · Cited by 70 · see citing works
Bryant, D., Holtby, R. M., Willits, K. R., Litchfield, R. B., Drosdowech, D. S., Spouge, A. R., White, D. M., & Guyatt, G. H. (2016) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2016.06.006 · Cited by 69 · see citing works
Assessment of the canine model of rotator cuff injury and repair
Derwin, K. A., Baker, A. R., Codsi, M. J., & Iannotti, J. P. (2007) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2007.04.002 · Cited by 62 · see citing works
Animal Models for Translational Research on Shoulder Pathologies
Longo, U. G., Forriol, F., Campi, S., Maffulli, N., & Denaro, V. (2011) · Sports Medicine and Arthroscopy Review · doi:10.1097/jsa.0b013e318205470e · Cited by 60 · see citing works
Roßbach, B. P., Güleçyüz, M. F., Kempfert, L., Pietschmann, M. F., Ullamann, T., Ficklscherer, A., Niethammer, T. R., Zhang, A., Klar, R. M., & Müller, P. E. (2019) · The American Journal of Sports Medicine · doi:10.1177/0363546519892580 · Cited by 56 · see citing works
Use of small intestine submucosa in a rat model of acute and chronic rotator cuff tear
Perry, S. M., Gupta, R. R., Kleunen, J. P. V., Ramsey, M. L., Soslowsky, L. J., & Glaser, D. L. (2007) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2007.03.009 · Cited by 52 · see citing works
Romeo, A. A., Easley, J. T., Regan, D. P., Hackett, E. S., Johnson, J. W., Johnson, J. K., Puttlitz, C. M., & McGilvray, K. C. (2021) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2021.07.018 · Cited by 47 · see citing works
Sarrafian, T. L., Wang, H., Hackett, E. S., Yao, J. Q., Shih, M., Ramsay, H. L., & Turner, A. S. (2010) · The Journal of Foot & Ankle Surgery · doi:10.1053/j.jfas.2009.12.005 · Cited by 46 · see citing works
Self-citationRotator cuff repair using a decellularized tendon slices graft: an in vivo study in a rabbit model
Pan, J., Liu, G., Ning, L., Zhang, Y., Luo, J., Huang, F., & Qin, T. (2014) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-014-2923-7 · Cited by 45 · see citing works
Tendon tissue engineering: biomechanical considerations
Jaiswal, D., Yousman, L. C., Neary, M., Fernschild, E., Zolnoski, B., Katebifar, S., Rudraiah, S., Mazzocca, A. D., & Kumbar, S. G. (2020) · Biomedical Materials · doi:10.1088/1748-605x/ab852f · Cited by 45 · see citing works
Biomechanical Fixation in Arthroscopic Rotator Cuff Repair
Nho, S. J., Yadav, H., Pensak, M. J., Dodson, C. C., Good, C. R., & MacGillivray, J. D. (2007) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2006.10.010 · Cited by 44 · see citing works
Does Augmentation with a Reinforced Fascia Patch Improve Rotator Cuff Repair Outcomes?
Baker, A. R., McCarron, J. A., Tan, C. D., Iannotti, J. P., & Derwin, K. A. (2012) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-012-2348-x · Cited by 43 · see citing works
Shea, K. P., McCarthy, M. B., Ledgard, F., Arciero, C. L., Chowaniec, D. M., & Mazzocca, A. D. (2010) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2010.01.020 · Cited by 40 · see citing works
Synthetic Augmentation in Massive Rotator Cuff Tears
Longo, U. G., Lamberti, A., Rizzello, G., Maffulli, N., & Denaro, V. (2011) · Medicine and sport science/Medicine and sport · doi:10.1159/000328891 · Cited by 38 · see citing works
Synthetic Augmentation for Massive Rotator Cuff Tears
Longo, U. G., Lamberti, A., Khan, W. S., Maffulli, N., & Denaro, V. (2011) · Sports Medicine and Arthroscopy Review · doi:10.1097/jsa.0b013e318224e359 · Cited by 38 · see citing works
Rothrauff, B. B., Pauyo, T., Debski, R. E., Rodosky, M. W., Tuan, R. S., & Musahl, V. (2017) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2016.0446 · Cited by 37 · see citing works
Liu, G., Pan, J., Zhang, Y., Ning, L., Luo, J., Huang, F., & Qin, T. (2018) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2018.04.019 · Cited by 37 · see citing works
Easley, J. T., Puttlitz, C. M., Hackett, E. S., Broomfield, C., Nakamura, L., Hawes, M. L., Getz, C. L., Frankle, M. A., Pierre, P. S., Tashjian, R. Z., et al. (2019) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2019.05.024 · Cited by 37 · see citing works
Rotator Cuff Repair With Patch Augmentation: What Do We Know?
Cobb, T. E., Dimock, R. A. C., Memon, S. D., Consigliere, P., Ajami, S., Imam, M. A., & Narvani, A. A. (2022) · PubMed Central · doi:10.22038/abjs.2022.61345.3012 · Cited by 31 · see citing works
Klinger, H.-M., BUCHHORN, G. H., Heidrich, G., Kahl, E., & Baums, M. H. (2007) · Clinical Biomechanics · doi:10.1016/j.clinbiomech.2007.10.010 · Cited by 30 · see citing works
Rotator cuff: biology and current arthroscopic techniques
Lorbach, O., & Tompkins, M. A. (2012) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-012-1901-1 · Cited by 28 · see citing works
Decellularized Human Dermis to Treat Massive Rotator Cuff Tears: In Vitro Evaluations
Fini, M., Bondioli, E., Castagna, A., Torricelli, P., Giavaresi, G., Rotini, R., Marinelli, A., Guerra, E., Orlandi, C., Carboni, A., et al. (2011) · Connective Tissue Research · doi:10.3109/03008207.2011.649929 · Cited by 25 · see citing works
Yang, J., Kang, Y., Zhao, W., Jiang, J., Jiang, Y., Zhao, B. Q., Jiao, M., Yuan, B., Zhao, J., & Ma, B. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.08.016 · Cited by 24 · see citing works
Research progress of gut microbiota and frailty syndrome
Wang, X. Q., & Wu, M. (2021) · Open Medicine · doi:10.1515/med-2021-0364 · Cited by 23 · see citing works
Review Article: Regenerative Techniques for Repair of Rotator Cuff Tears
Ahmad, Z., HENSON, F. M. D., Wardale, J., Noorani, A. M., Tytherleigh-Strong, G. M., & Rushton, N. (2013) · Journal of orthopaedic surgery · doi:10.1177/230949901302100223 · Cited by 22 · see citing works
Biomechanical Analysis of Rotator Cuff Repairs With Extracellular Matrix Graft Augmentation
Ely, E. E., Figueroa, N. M., & Gilot, G. J. (2014) · Orthopedics · doi:10.3928/01477447-20140825-05 · Cited by 21 · see citing works
Johnson, J. W., von Stade, D., Gadomski, B. C., Easley, J. T., Nelson, B. B., Bisazza, K. T., Regan, D. P., Troyer, K. L., Zhou, T., & McGilvray, K. C. (2022) · The American Journal of Sports Medicine · doi:10.1177/03635465221125175 · Cited by 20 · see citing works
New perspectives in rotator cuff tendon regeneration: review of tissue engineered therapies
Rotini, R., Fini, M., Giavaresi, G., Marinelli, A., Guerra, E., Antonioli, D., Castagna, A., & Giardino, R. (2008) · La Chirurgia degli Organi di Movimento · doi:10.1007/s12306-007-0015-2 · Cited by 20 · see citing works
Yokoya, S., Harada, Y., Negi, H., Matsushita, R., Matsubara, N., & Adachi, N. (2020) · Orthopaedic Journal of Sports Medicine · doi:10.1177/2325967120960166 · Cited by 19 · see citing works
Zhang, X., Fang, Z., Cho, E., Huang, K., Zhao, J., Jiang, J., & Huangfu, X. (2019) · BioMed Research International · doi:10.1155/2019/9346567 · Cited by 18 · see citing works
Recent Scientific Advances Towards the Development of Tendon Healing Strategies
Sayegh, E. T., Sandy, J. D., Virk, M. S., Romeo, A. A., Wysocki, R. W., Galante, J. O., Trella, K. J., Plaas, A., & Wang, V. M. (2015) · Current Tissue Engineering · doi:10.2174/2211542004666150713190231 · Cited by 18 · see citing works
The Porcine Small Intestinal Submucosa (SIS) Patch in Foot and Ankle Reconstruction
Bibbo, C. (2009) · The Journal of Foot & Ankle Surgery · doi:10.1053/j.jfas.2009.09.004 · Cited by 17 · see citing works
Biphasic Interpositional Allograft for Rotator Cuff Repair Augmentation Is Safe in an Ovine Model
Credille, K. T., Wang, Z. R. C., Horner, N. S., Regan, D. P., Gadomski, B. C., Easley, J. T., Garrigues, G. E., & Yanke, A. B. (2023) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2023.03.018 · Cited by 15 · see citing works
Provencher, M. T., Mazzocca, A. D., & Romeo, A. A. (2007) · Techniques in Orthopaedics · doi:10.1097/01.bto.0000261758.10190.4e · Cited by 15 · see citing works
Min, H. K., Kwon, O. S., Oh, S. H., & Lee, J. H. (2016) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-016-9120-3 · Cited by 13 · see citing works
Johnson, J. W., von Stade, D., Regan, D. P., Easley, J. T., Chow, L., Dow, S., Romeo, T., Schlegel, T., & McGilvray, K. C. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-354 · Cited by 13 · see citing works
Self-citationLeigh, D. R., Mesiha, M., Baker, A. R., Walker, E., & Derwin, K. A. (2012) · Journal of Orthopaedic Research® · doi:10.1002/jor.22149 · Cited by 13 · see citing works
An Update on Scaffold Devices for Rotator Cuff Repair
Amini, M. H., Ricchetti, E. T., Iannotti, J. P., & Derwin, K. A. (2017) · Techniques in Shoulder & Elbow Surgery · doi:10.1097/bte.0000000000000122 · Cited by 12 · see citing works
Trends in rotator cuff surgery: Research through the decades
Viswanath, A. I., & Monga, P. (2021) · Journal of Clinical Orthopaedics and Trauma · doi:10.1016/j.jcot.2021.04.011 · Cited by 12 · see citing works
Fascia lata allograft bridging of a rotator cuff tear in a rabbit animal model.
Varvitsiotis, D., Papaspiliopoulos, A., Vlachou, V., Feroussis, J., Papalois, A. E., Papacharalampous, X. N., Soucacos, P. N., & Zoubos, A. B. (2014) · Europe PMC (PubMed Central) · doi:10.4103/0973-6042.137526 · Cited by 11 · see citing works
Culture of human rotator cuff cells on orthobiologic support (porcine small intestinal submucosa
Gumina, S., PATTI, A. M., Vulcano, A., Rocca, C. D., & Postacchini, F. (2009) · MUSCULOSKELETAL SURGERY · doi:10.1007/s12306-009-0005-7 · Cited by 11 · see citing works
Gluteus Maximus Avulsion and Closed Degloving Lesion Associated with a Thoracolumbar Burst Fracture
Gwinn, D. E., Morgan, R., & Kumar, A. R. (2007) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.f.00706 · Cited by 11 · see citing works
Klinger, H.-M., Koelling, S., Baums, M. H., Kahl, E., Steckel, H., Smith, M. M., Schultz, W., & Miosge, N. (2009) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2008.00791.x · Cited by 10 · see citing works
No prosthetic management of massive and irreparable rotator cuff tears
Castagna, A., Garofalo, R., & Cesari, E. (2014) · Shoulder & Elbow · doi:10.1177/1758573214535369 · Cited by 10 · see citing works
Johnson, J. W., von Stade, D., Regan, D. P., Easley, J. T., Chow, L., Dow, S., Romeo, T., Schlegel, T., & McGilvray, K. C. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-2749 · Cited by 10 · see citing works
Self-citationCombined Growth Factor Hydrogel Enhances Rotator Cuff Enthesis Healing in Rat But Not Sheep Model
Bolam, S. M., Zhu, M. F., Lim, K. S., Konar, S., Oliver, M. H., Buckels, E. J., Matthews, B. G., Callon, K. E., Woodfield, T. B. F., Workman, J., et al. (2023) · Tissue Engineering Part A · doi:10.1089/ten.tea.2022.0215 · Cited by 9 · see citing works
Wang, J., Yu, X., Bai, Y., Wang, P.-Z., & Liu, C.-Y. (2020) · Livestock Science · doi:10.1016/j.livsci.2020.104208 · Cited by 9 · see citing works
Biomechanical enhancement in rotator cuff repairs: the impact of innovative nanofiber technology
Johnson, J. W., Gadomski, B., Regan, D. P., Johnson, J., Nelson, B. B., McGilvray, K. C., Labus, K. M., Romeo, A. A., & Easley, J. T. (2024) · JSES International · doi:10.1016/j.jseint.2024.08.203 · Cited by 7 · see citing works
Johnson, J. W., von Stade, D., Gadomski, B. C., Regan, D. P., Easley, J. T., Sikes, K. J., Troyer, K. L., Zhou, T., Schlegel, T., & McGilvray, K. C. (2023) · Journal of Orthopaedic Research® · doi:10.1002/jor.25529 · Cited by 6 · see citing works
Self-citationLionello, G., Fognani, R., Baleani, M., Sudanese, A., & Toni, A. (2015) · Clinical Biomechanics · doi:10.1016/j.clinbiomech.2015.09.003 · Cited by 6 · see citing works
Yoon, J. P., Park, S.-J., Kim, D.-H., Choi, Y. S., Lee, H., Kim, J.-Y., Park, E. J.-J., & Chung, S. W. (2025) · Clinics in Orthopedic Surgery · doi:10.4055/cios24490 · Cited by 5 · see citing works
Wood, C. J., & Cashmore, R. G. (2021) · VCOT Open · doi:10.1055/s-0041-1725056 · Cited by 5 · see citing works
The Clinical Application of Gel-Based Composite Scaffolds in Rotator Cuff Repair
Tharakan, S., Hadjiargyrou, M., & Ilyas, A. (2024) · Gels · doi:10.3390/gels11010002 · Cited by 5 · see citing works
Biomechanical properties of tendons and ligaments in humans and animals
Buschmann, J., & Bürgisser, G. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-100489-0.00002-8 · Cited by 5 · see citing works
Biologic Patches for Management of Irreparable Rotator Cuff Tears
Burns, J. P., & Snyder, S. J. (2009) · Techniques in Shoulder & Elbow Surgery · doi:10.1097/bte.0b013e3181938499 · Cited by 4 · see citing works
Biomechanical Effects of Fiber Patch Augmentation on Rotator Cuff Repairs
Mehta, V., Mandala, C. L., Shriver, R. J., & Benson, M. R. (2019) · Orthopedics · doi:10.3928/01477447-20191031-06 · Cited by 4 · see citing works
Overview of Orthobiology and Biomechanics
Chahla, J. A., Cinque, M. E., LaPrade, R. F., & Mandelbaum, B. R. (2017) · Springer eBooks · doi:10.1007/978-3-662-54181-4_2 · Cited by 4 · see citing works
Gluteus Maximus Avulsion and Closed Degloving Lesion Associated with a Thoracolumbar Burst Fracture
Gwinn, D. E., Morgan, R., & Kumar, A. (2007) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200702000-00028 · Cited by 4 · see citing works
Utilización de injertos en la reparación de rerroturas del manguito rotador
Jiménez-Martín, A., Santos-Yubero, F. J., Najarro-Cid, F. J., Navarro-Martínez, S., Zurera-Carmona, M., & Pérez-Hidalgo, S. (2016) · Revista Española de Cirugía Ortopédica y Traumatología · doi:10.1016/j.recot.2016.06.003 · Cited by 3 · see citing works
Use of grafts in rotator cuff re-rupture
Jiménez-Martín, A., Santos-Yubero, F. J., Najarro-Cid, F. J., Navarro-Martínez, S., Zurera-Carmona, M., & Pérez-Hidalgo, S. (2016) · Revista Española de Cirugía Ortopédica y Traumatología · doi:10.1016/j.recote.2016.08.002 · Cited by 3 · see citing works
Lesiones masivas del manguito de los rotadores
Hernández, P. J. L. (2016) · Revista Colombiana de Ortopedia y Traumatología · doi:10.1016/j.rccot.2016.09.007 · Cited by 2 · see citing works
Biologic Scaffold Materials for Orthopaedic Soft Tissue Reconstruction
Badylak, S. F. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-239-7_21 · Cited by 2 · see citing works
Biologic Augmentation of Rotator Cuff Repair
Caldwell, J.-M. E., Zhang, X., Lu, H. H., & Levine, W. N. (2015) · Springer eBooks · doi:10.1007/978-3-319-25103-5_17 · Cited by 2 · see citing works
Rotator Cuff Augmentation: Its Role and Best Practices
Ciccone, W. J., Geers, B. A., Jensen, B., & Bishai, S. K. (2023) · Sports Medicine and Arthroscopy Review · doi:10.1097/jsa.0000000000000375 · Cited by 2 · see citing works
Histologic outcomes of rotator cuff patch augmentation: a literature review
Hitchens, H. R., FANG, W. H., Mo, K., Bascharon, R. A., Winder, R., & Vangsness, T. (2026) · JSES Reviews Reports and Techniques · doi:10.1016/j.xrrt.2026.100721 · Cited by 1 · see citing works
Scaffold Design for Integrative Tendon–Bone Repair
Zhang, X., Levine, W. N., & Lu, H. H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801590-2.00015-6 · Cited by 1 · see citing works
Rotator Cuff Injuries: The Evolving Role Of Tissue Engineering
Pastides, P., & Khan, W. S. (2011) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.7791 · Cited by 1 · see citing works
- What have we learned from animal models?
Uta Griesenbach, D. (2015) · CRC Press eBooks · doi:10.1201/b18629-11 · Cited by 1 · see citing works
- Authors
- Schlegel, T. F., Hawkins, R. J., Lewis, C. W., Motta, T., & Turner, A. S.
- Affiliations
- Steadman Clinic (US)
- Colorado State University (US)
- ORCID
- Hawkins, Richard J.
- Venue
- The American Journal of Sports Medicine
- Publisher
- SAGE Publications
- Published
- 2006-02
- Volume
- 34
- Issue
- 2
- Pages
- 275-280
- ISSN
- 0363-5465 (ISSN-L)
- 1552-3365
- OpenAlex
- W2133103125
- Cited by
- 126
- References
- 16
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 7 · 2013: 5 · 2012: 7
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Shoulder Injury and Treatment
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Health Sciences › Medicine › Surgery › Orthopedic Surgery and Rehabilitation
- Keywords
- small intestinal submucosa, tendon healing, rotator cuff repair, tendon augmentation, infraspinatus tendon, tendon-bone interface, stiffness, load to failure, cyclic loading, early rehabilitation, sheep model
- MeSH terms
- Animals, Arthroplasty, Biomechanical Phenomena, Disease Models, Animal, Intestinal Mucosa, Intestine, Small, Sheep, Swine, Tendon Injuries, Tendons, Transplantation, Heterologous, Wound Healing, Rotator Cuff, Treatment Failure, Models, Animal
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