The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Analysis of a Semitendinosus Autograft in a Rabbit Model
Abstract
The purpose of this study was to evaluate the histo logic and biomechanical changes that occur between 12 and 52 weeks in an intraarticular, semitendinosus autograft placed through tibial and femoral drill holes in a rabbit model. The results of this study show that, in this rabbit model, the soft tissue graft maintained its biologic fixation in the osseous tunnel when stressed to failure at 1 year. The bony fixation occurred by the formation of an indirect tendon insertion, and this for mation was complete by 26 weeks. At 52 weeks, large differences persisted in the strength and stiffness of the graft compared with the normal semitendinosus tendon and anterior cruciate ligament. Based on the results of this study, we support a cautious approach in returning patients to early full activity, including sports, after anterior cruciate ligament reconstruction with a semitendinosus autograft.
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“This is consistent with previous animal studies that reported excessive graft necrosis in the early phase, followed by an influx of fibroblasts [53, 67, 68].”
Citations
Cites
Biomechanical analysis of human ligament grafts used in knee-ligament repairs and reconstructions.
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Anterior Cruciate Ligament Graft Fixation
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An Analysis of Autograft Fixation After Anterior Cruciate Ligament Reconstruction in a Rabbit Model
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Biologic fixation of ligament prostheses and augmentations
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THE BIOLOGY OF ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTIONS
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Effects of fibrin sealant on incorporation of autograft and xenograft tendons within bone tunnels
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Cited by
Sorted by citations
Treatment of Anterior Cruciate Ligament Injuries, Part I
Beynnon, B. D., Johnson, R. J., Abate, J. A., Fleming, B. C., & Nichols, C. E. (2005) · The American Journal of Sports Medicine · doi:10.1177/0363546505279913 · Cited by 653
Mikos, A. G., Herring, S. W., Ochareon, P., Elisseeff, J. H., Lu, H. H., Kandel, R. A., Schöen, F. J., Toner, M., Mooney, D. J., Atala, A., et al. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.3307 · Cited by 598
Current Trends in Anterior Cruciate Ligament Reconstruction
Fu, F. H., Bennett, C., Lattermann, C. M., & Ma, C. B. (1999) · The American Journal of Sports Medicine · doi:10.1177/03635465990270062501 · Cited by 564
Atala, A., Kasper, F. K., & Mikos, A. G. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004890 · Cited by 559
Tendon healing in a bone tunnel. Part II
Weiler, A., Hoffmann, R. F. G., Bail, H. J., Rehm, O., & Südkamp, N. P. (2002) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1053/jars.2002.30657 · Cited by 480
Metadata
- Authors
- Blickenstaff, K. R., Grana, W. A., & Egle, D.
- Affiliations
- Winchester Medical Center (US)
- University of Oklahoma Health Sciences Center (US)
- University of Oklahoma (US)
- Venue
- The American Journal of Sports Medicine
- Publisher
- SAGE Publications
- Published
- 1997-07
- Volume
- 25
- Issue
- 4
- Pages
- 554-559
- ISSN
- 0363-5465 (ISSN-L)
- 1552-3365
- OpenAlex
- W2083179020
- Cited by
- 164
- References
- 15
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 2 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 5
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Foot and Ankle Surgery
- Keywords
- semitendinosus autograft, anterior cruciate ligament reconstruction, rabbit model, graft histology, graft biomechanics, graft stiffness, return to sport
- MeSH terms
- Activities of Daily Living, Animals, Biomechanical Phenomena, Collagen, Connective Tissue, Disease Models, Animal, Elasticity, Evaluation Studies as Topic, Femur, Follow-Up Studies, Hindlimb, Humans, Rabbits, Rupture, Sports, Stress, Mechanical, Tendons, Tibia, Transplantation, Autologous, Wound Healing, Anterior Cruciate Ligament
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