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Apligraf – a Living Human Skin Equivalent for the Treatment of Chronic Wounds
Abstract
Apligraf, a manufactured living human skin equivalent, was the first true composite tissue analog to become commercially available. It has been approved by the FDA for the treatment of venous leg ulcers and diabetic foot ulcers. The tissue engineered bi-layered skin equivalent has both an epidermis and a dermis, which consist of keratinocytes and fibroblasts derived from neonatal foreskin and bovine collagen. The skin equivalent produces a great number of cytokines and growth factors and is immunologically well tolerated. The product is easy to handle in clinical use and can be applied in an outpatient setting.
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“Its exact mechanism of action is not known, but it is known to produce cytokines and growth factors similar to healthy human skin.”
From A review of a bi-layered living cell treatment (Apligraf) in the treatment of venous leg ulcers and diabetic foot ulcers (2007) · cites this paper as Streit and Braathen 2000
In the citing paper
“The mechanism of action of Apligraf in the promotion of wound healing is not fully understood; however, it is known to produce a great number of cytokines and growth factors (Streit and Braathen 2000; Falanga et al 2002) which are thought to be responsible for stimulating differentiation and proliferation in an otherwise senescent, nonhealing wound bed.”
From A review of a bi-layered living cell treatment (Apligraf) in the treatment of venous leg ulcers and diabetic foot ulcers (2007) · cites this paper as Streit and Braathen 2000
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Cited by
Zaulyanov, L., & Kirsner, R. S. (2007) · Clinical Interventions in Aging · doi:10.2147/ciia.2007.2.1.93 · Cited by 266
Plant-derived human collagen scaffolds for skin tissue engineering
Willard, J. J., Drexler, J. W., Das, A., Roy, S., Shilo, S., Shoseyov, O., & Powell, H. M. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0338 · Cited by 87
Metadata
- Authors
- Streit, M., & Braathen, L. R.
- Venue
- The International Journal of Artificial Organs
- Publisher
- SAGE Publications
- Published
- 2000-12
- Volume
- 23
- Issue
- 12
- Pages
- 831-833
- ISSN
- 0391-3988
- 1724-6040
- Cited by
- 48
- References
- 0
- Language
- en
- Licence
- journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
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