Cited by 199Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.

GABAergic Function in Alzheimer's Disease: Evidence for Dysfunction and Potential as a Therapeutic Target for the Treatment of Behavioural and Psychological Symptoms of Dementia

Open access

Lanctôt, Krista L, Herrmann, Nathan, Mazzotta, Paolo, Khan, Lyla R, Ingber, Neil·2004·The Canadian Journal of Psychiatry

DOI 10.1177/070674370404900705

Open this paper in CoChat — free account Open PDF

Abstract

Alzheimer's disease (AD) is characterized by disruptions in multiple major neurotransmitters. While many studies have attempted to establish whether GABA is disrupted in AD patients, findings have varied. We review evidence for disruptions in GABA among patients with AD and suggest that the variable findings reflect subtypes of the disease that are possibly manifested clinically by differing behavioural symptoms. GABA, the major inhibitory neurotransmitter, has long been a target for anxiolytics, hypnotic sedatives, and anticonvulsants. We review the clinical use of GABAergic agents in treating persons with AD symptoms. While newer generation GABAergic medications are now available, they have yet to be evaluated among patients with AD.

Integrity signals

Registry

Crossref · 10.1177/070674370404900705

Cites

147 of 147 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Psychopharmacology: The third generation of progress
O’Connell, R. A. (1988) · Comprehensive Psychiatry · doi:10.1016/0010-440x(88)90057-0 · Cited by 3,020
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.
Perry, E., Tomlinson, B. E., Blessed, G., Bergmann, K., Gibson, P., & Perry, R. H. (1978) · British medical journal · doi:10.1136/bmj.2.6150.1457 · Cited by 2,043
Psychopharmacology: The Third Generation of Progress.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-509_2 · Cited by 2,021
The Biochemical Basis of Neuropharmacology.
(1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-81-4-575_2 · Cited by 1,882
Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
Whitehouse, P. J., Price, D. L., Clark, A. W., Coyle, J. T., & DeLong, M. R. (1981) · Annals of Neurology · doi:10.1002/ana.410100203 · Cited by 1,736
Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes
Rudolph, U., Crestani, F., Benke, D., Brünig, I., Benson, J. A., Fritschy, J.-M., Martin, J. R., Bluethmann, H., & Möhler, H. (1999) · Nature · doi:10.1038/44579 · Cited by 1,172
Diagnosis and Treatment of Alzheimer Disease and Related Disorders
Small, G. W. (1997) · JAMA · doi:10.1001/jama.1997.03550160083043 · Cited by 992
Molecular and neuronal substrate for the selective attenuation of anxiety
Löw, K., Crestani, F., Keist, R., Benke, D., Brünig, I., Benson, J. A., Fritschy, J.-M., Rülicke, T., Bluethmann, H., Möhler, H., et al. (2000) · Science · doi:10.1126/science.290.5489.131 · Cited by 946
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype
McKernan, R. M., Rosahl, T. W., Reynolds, D. S., Sur, C., Wafford, K. A., Atack, J. R., Farrar, S., Myers, J., Cook, G., Ferris, P., et al. (2000) · Nature Neuroscience · doi:10.1038/75761 · Cited by 944
Neurotransmitter-related enzymes in senile dementia of the alzheimer type
Davies, P. (1979) · Brain Research · doi:10.1016/0006-8993(79)90336-6 · Cited by 634
The ‘ABC’ of GABA receptors
Bormann, J. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01413-3 · Cited by 629
GABA receptor mechanisms in the central nervous system
Sivilotti, L. G., & Nistri, A. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90036-z · Cited by 553
The role of interactions between the cholinergic system and other neuromodulatory systems in learing and memory
Decker, M. W., & McGaugh, J. L. (1991) · Synapse · doi:10.1002/syn.890070209 · Cited by 527
A POST-MORTEM STUDY OF THE CHOLINERGIC AND GABA SYSTEMS IN SENILE DEMENTIA
Rossor, M. N., Garrett, N., Johnson, A. L., Mountjoy, C. Q., Roth, M., & Iversen, L. L. (1982) · Brain · doi:10.1093/brain/105.2.313 · Cited by 460
The ABC of GABA receptors: a brief review
Chebib, M., & Johnston, G. A. R. (1999) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.1999.03151.x · Cited by 436
Efficacy and Tolerability of Carbamazepine for Agitation and Aggression in Dementia
Tariot, P. N., Erb, R., Podgorski, C. A., Cox, C., Patel, S., Jakimovich, L., & Irvine, C. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.1.54 · Cited by 422
Neurochemical characteristics of early and late onset types of Alzheimer's disease.
Rossor, M. N., Iversen, L. L., Reynolds, G. P., Mountjoy, C. Q., & Roth, M. (1984) · BMJ · doi:10.1136/bmj.288.6422.961 · Cited by 415
Studies of the uptake of3H-GABA and [3H]glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography
Iversen, L. L., & Bloom, F. E. (1972) · Brain Research · doi:10.1016/0006-8993(72)90621-x · Cited by 369
The Course of Psychopathologic Features in Mild to Moderate Alzheimer Disease
Devanand, D. P. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830150083012 · Cited by 347
Pre- and postsynaptic neurochemical alterations in Alzheimer's disease
Reisine, T., Yamamura, H. I., Bird, E. D., Spokes, E. G., & Enna, S. J. (1978) · Brain Research · doi:10.1016/0006-8993(78)90562-0 · Cited by 342
The Biochemical Basis of Neuropharmacology
(1997) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(97)89442-5 · Cited by 329
Transmitter deficits in Alzheimer's disease
Hardy, J., Adolfsson, R., Alafuzoff, I. I., Bucht, G., Marcusson, J. O., Nyberg, P., Perdahl, E., Wester, P. O., & Winblad, B. G. (1985) · Neurochemistry International · doi:10.1016/0197-0186(85)90050-6 · Cited by 327
Dementia of the Alzheimer's Type: Changes in Hippocampal L‐[ 3 H]Glutamate Binding
Greenamyre, J. T., Penney, J. B., D’Amato, C. J., & Young, A. B. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb04127.x · Cited by 278
The Cholinergic Hypothesis of Neuropsychiatric Symptoms in Alzheimer's Disease
Cummings, J. L., & Back, C. (1998) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-199821001-00009 · Cited by 276
The Glutamatergic System and Alzheimer???s Disease
Butterfield, D. A., & Pocernich, C. B. (2003) · CNS Drugs · doi:10.2165/00023210-200317090-00004 · Cited by 274
Enzyme Activities in Relation to pH and Lactate in Postmortem Brain in Alzheimer‐Type and Other Dementias
Yates, C. M., Butterworth, J., Tennant, M. C., & Gordon, A. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04948.x · Cited by 263
Neuropsychiatric aspects of Alzheimer's disease
Cummings, J. L., & Kaufer, D. (1996) · Neurology · doi:10.1212/wnl.47.4.876 · Cited by 252
Amino Acid Transmitters
Curtis, D. R., & Johnston, G. A. R. (1970) · Springer eBooks · doi:10.1007/978-1-4615-7163-6_5 · Cited by 232
Placebo-Controlled Study of Divalproex Sodium for Agitation in Dementia
Porsteinsson, A. P., Tariot, P. N., Erb, R., Cox, C., Smith, E., Jakimovich, L. J., Noviasky, J. A., Kowalski, N., Holt, C. J., & Irvine, C. (2001) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200102000-00009 · Cited by 206
GABA and hippocampal inhibition
Curtis, D. R., Felix, D., & McLellan, H. (1970) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1970.tb10663.x · Cited by 199
Comparison of Rapidly Acting Intramuscular Olanzapine, Lorazepam, and Placebo A Double-blind, Randomized Study in Acutely Agitated Patients with Dementia
Meehan, K. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00365-7 · Cited by 198
Alzheimer's disease: Changes in hippocampal N-methyl-d-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors—an autoradiographic study
Jansen, K. L. R., Faull, R. L. M., Dragunow, M., & Synek, B. J. L. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90246-z · Cited by 197
A Pilot Randomized Trial of Carbamazepine for Behavioral Symptoms in Treatment-Resistant Outpatients with Alzheimer Disease
Olin, J. T., Fox, L. S., Pawluczyk, S., Taggart, N. A., & Schneider, L. S. (2001) · The American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200111000-00008 · Cited by 163
A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease
Reinikainen, K. J., Paljärvi, L., Huuskonen, M., Soininen, H. S., Laakso, M., & Riekkinen, P. J. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90179-7 · Cited by 154
Role of Serotonin in the Behavioral and Psychological Symptoms of Dementia
Lanctôt, K. L., Herrmann, N., & Mazzotta, P. (2001) · Journal of Neuropsychiatry · doi:10.1176/jnp.13.1.5 · Cited by 153
Self-citation
Cerebrospinal fluid levels of transition metals in patients with Parkinson's disease
Jiménez‐Jiménez, F. J., Molina, J. A., Aguilar, M. V., Meseguer, I., Mateos-Vega, C. J., González‐Muñoz, M. J., de Bustos, F., Martínez‐Salio, A., Pareja, M. O., Zurdo, M., et al. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050073 · Cited by 151
Benzodiazepines as antidepressants: Does GABA play a role in depression?
Petty, F., Trivedi, M. H., Fulton, M., & Rush, A. J. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(95)00049-7 · Cited by 143
A postmortem study of amino acid neurotransmitters in Alzheimer's disease
Ellison, D. W., Beal, M. F., Mazurek, M. F., Bird, E. D., & Martin, J. B. (1986) · Annals of Neurology · doi:10.1002/ana.410200510 · Cited by 141
Levels of -Aminobutyric Acid in Cerebrospinal Fluid in Various Neurologic Disorders
Manyam, N. V. B., Katz, L., Hare, T. A., Gerber, J. C., & Grossman, M. H. (1980) · Archives of Neurology · doi:10.1001/archneur.1980.00500550054006 · Cited by 135
GAMMA-AMINOBUTYRIC ACID CONCENTRATION IN BRAIN TISSUE AT TWO STAGES OF ALZHEIMER'S DISEASE
Lowe, S. L., Francis, P. T., PROCTER, A. W., Palmer, A. M., DAVISON, A. N., & Bowen, D. M. (1988) · Brain · doi:10.1093/brain/111.4.785 · Cited by 132
Cerebrospinal Fluid -Aminobutyric Acid Variations in Neurological Disorders
Enna, S. J., Stern, L. Z., Wastek, G. J., & Yamamura, H. I. (1977) · Archives of Neurology · doi:10.1001/archneur.1977.00500230053008 · Cited by 121
Amino acids, glutathione, and glutathione transferase activity in the brains of patients with Alzheimer's disease
Perry, T. L., Yong, V. W., Bergeron, C., Hansen, S., & Jones, K. L. (1987) · Annals of Neurology · doi:10.1002/ana.410210403 · Cited by 121
Carbamazepine Treatment of Agitation in Nursing Home Patients with Dementia: A Preliminary Study
Tariot, P. N., Erb, R., Leibovici, A., Podgorski, C. A., Cox, C., Asnis, J., Kolassa, J. E., & Irvine, C. (1994) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1994.tb06982.x · Cited by 120
Safety and tolerability of divalproex sodium in the treatment of signs and symptoms of mania in elderly patients with dementia: results of a double-blind, placebo-controlled trial
Tariot, P. N., Schneider, L. S. S., Mintzer, J. E., Cutler, A. J., Cunningham, M. R., Thomas, J. W., & Sommerville, K. W. (2001) · Current Therapeutic Research · doi:10.1016/s0011-393x(01)80042-4 · Cited by 118
A disorder of cortical GABAergic innervation in Alzheimer's disease
Hardy, J., Cowburn, R. F., BARTON, A. J. L., Reynolds, G. P., Dodd, P. R., Wester, P. O., O’Carroll, A., Lofdahl, E., & Winblad, B. G. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90016-4 · Cited by 116
Pharmacologic treatment of noncognitive behavioral disturbances in elderly demented patients
Coccaro, E. F., Kramer, E., Zemishlany, Z., Thorne, A., Rice, C. M., Giordani, B., Duvvi, K., Patel, B. M., Torres, J., & Nora, R. M. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.12.1640 · Cited by 115
Sodium valproate in the treatment of aggressive behavior in patients with dementia—a randomized placebo controlled clinical trial
Sival, R. C., Haffmans, P. M. J., Jansen, P. A. F., Duursma, S. A., & Eikelenboom, P. (2002) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.653 · Cited by 115
Valproate in the treatment of behavioral agitation in elderly patients with dementia
Lott, A. D., McElroy, S. L., & Keys, M. (1995) · Journal of Neuropsychiatry · doi:10.1176/jnp.7.3.314 · Cited by 114
Insights into the structure and function of GABA-benzodiazepine receptors: ion channels and psychiatry
Zorumski, C. F., & Isenberg, K. E. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.2.162 · Cited by 112
The selectivity of the reduction of serotonin S2 receptors in Alzheimer-type dementia
Cross, A. J., Crow, T. J., Ferrier, I. N., & Johnson, J. A. (1986) · Neurobiology of Aging · doi:10.1016/0197-4580(86)90019-9 · Cited by 112
Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type
Sasaki, H., Muramoto, O., Kanazawa, I., Arai, H., Kosaka, K., & Iizuka, R. (1986) · Annals of Neurology · doi:10.1002/ana.410190307 · Cited by 110
Sodium Valproate in the Treatment of Behavioral Disturbance in Dementia
Mellow, A. M., Solano-Lopez, C., & Davis, S. (1993) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879300600404 · Cited by 110
Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology
Seidl, R., Cairns, N. J., Singewald, N., Kaehler, S. T., & Lübec, G. (2001) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000346 · Cited by 109
Decreased CSF Concentrations of Homovanillic Acid and γ-Aminobutyric Acid in Alzheimer's Disease
Bareggi, S. R. (1982) · Archives of Neurology · doi:10.1001/archneur.1982.00510230035010 · Cited by 107
Benzodiazepines May Have Protective Effects Against Alzheimer Disease
Fastbom, J., Forsell, Y., & Winblad, B. G. (1998) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199803000-00002 · Cited by 102
Cortical GABA B and GABA A receptors in Alzheimer's disease
Chu, D. C. M., Penney, J. B., & Young, A. B. (1987) · Neurology · doi:10.1212/wnl.37.9.1454 · Cited by 100
Neurochemical substrates of rigidity and chorea in Huntington's disease
Storey, E., & Beal, M. F. (1993) · Brain · doi:10.1093/brain/116.5.1201 · Cited by 99
Neurotransmitter amino acids in cerebrospinal fluid of patients with Alzheimer's disease
Jiménez‐Jiménez, F. J., Molina, J. A., Gómez, P. A., Vargas, C., de Bustos, F., Benito‐León, J., Tallón-Barranco, A., Pareja, M. O., Gasalla, T., & Arenas, J. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050056 · Cited by 98
[3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type
Owen, F., Poulter, M., Waddington, J. L., Mashal, R. D., & Crow, T. J. (1983) · Brain Research · doi:10.1016/0006-8993(83)90276-7 · Cited by 95
Intralaminar Neurochemical Distributions in Human Midtemporal Cortex: Comparison Between Alzheimer's Disease and the Normal
Perry, E. K., Atack, J. R., Perry, R. H., Hardy, J., Dodd, P. R., Edwardson, J. A., Blessed, G., Tomlinson, B. E., & FAIRBAIRN, A. F. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb02801.x · Cited by 92
Carbamazepine treatment of agitation in Alzheimer's outpatients refractory to neuroleptics.
Gleason, R. P., & Ls, S. (1990) · PubMed · Cited by 92
GABA-ergic neurons and the neurobiology of schizophrenia and other psychoses
Keverne, E. B. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00025-8 · Cited by 86
New Insights Into The Mechanism of Action of Hypnotics
Doble, A. (1999) · Journal of Psychopharmacology · doi:10.1177/026988119901304s03 · Cited by 77
Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease
Smith, C., Bowen, D. M., Sims, N. R., Neary, D., & DAVISON, A. N. (1983) · Brain Research · doi:10.1016/0006-8993(83)91131-9 · Cited by 77
Positron Emission Tomography Measures of Benzodiazepine Binding in Alzheimer's Disease
Meyer, M., Koeppe, R. A., Frey, K. A., Foster, N. L., & Kuhl, D. E. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540270110027 · Cited by 75
Hippocampal Free Amino Acids in Alzheimer's Disease
Tarbit, I., Perry, E. K., Perry, R. H., Blessed, G., & Tomlinson, B. E. (1980) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1980.tb07883.x · Cited by 75
Nicotine-induced excitation of midbrain dopamine neurons in vitro involves ionotropic glutamate receptor activation
Grillner, P., & Svensson, T. H. (2000) · Synapse · doi:10.1002/1098-2396(200010)38:1 · Cited by 75
erratum: Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes
Rudolph, U., Crestani, F., Benke, D., Brünig, I., Benson, J. A., Fritschy, J., Martin, J. R., Bluethmann, H., & Möhler, H. (2000) · Nature · doi:10.1038/35007116 · Cited by 71
Valproic Acid Treatment of Agitation in Dementia
Herrmann, N. (1998) · The Canadian Journal of Psychiatry · doi:10.1177/070674379804300108 · Cited by 70
Self-citation
An Open Trial of Valproate for Agitation in Geriatric Neuropsychiatric Disorders
Porsteinsson, A. P., Tariot, P. N., Erb, R., & Gaile, S. (1997) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-199700540-00010 · Cited by 70
A preliminary study of free amino acids in the postmorten temporal cortex from Alzheimer-type dementia patients
Arai, H., Kobayashi, K., Ichimiya, Y., Kosaka, K., & Iizuka, R. (1984) · Neurobiology of Aging · doi:10.1016/0197-4580(84)90009-5 · Cited by 70
Quantitative autoradiography of hippocampal GABAB and GABAA receptor changes in Alzheimer's disease
Chu, D. C. M., Penney, J. B., & Young, A. B. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90264-3 · Cited by 69
Density and pharmacology of α5 subunit-containing GABAA receptors are preserved in hippocampus of Alzheimer’s disease patients
Howell, O. W., Atack, J. R., Dewar, D., McKernan, R. M., & Sur, C. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00163-9 · Cited by 67
Brain gamma-aminobutyrate aminotransferase (GABA-T) and monoamine oxidase (MAO) in patients with Alzheimer's disease
Sherif, F. M., Gottfries, C. G., Alafuzoff, I. I., & Oreland, L. (1992) · Journal of Neural Transmission - Parkinsons Disease and Dementia Section · doi:10.1007/bf02260906 · Cited by 67
-Aminobutyric Acid and Homovanillic Acid Concentration in the CSF of Patients With Senile Dementia of Alzheimer's Type
Zimmer, R., Teelken, A. W., Trieling, W. B., Weber, W., Weihmayr, T., & Lauter, H. (1984) · Archives of Neurology · doi:10.1001/archneur.1984.04210080010005 · Cited by 67
Serotonergic pathology is not widespread in Alzheimer patients without prominent aggressive symptoms
PROCTER, A. W., Francis, P. T., Stratmann, G. C., & Bowen, D. M. (1992) · Neurochemical Research · doi:10.1007/bf00993268 · Cited by 65
Drugs and stimulus-bound attack
Panksepp, J. (1971) · Physiology & Behavior · doi:10.1016/0031-9384(71)90162-4 · Cited by 64
An in vitro 1H nuclear magnetic resonance study of the temporoparietal cortex of Alzheimer brains
Mohanakrishnan, P., Fowler, A. H., Vonsattel, J. P., Husain, M. M., Jolles, P. R., Liem, P. H., & Komoroski, R. A. (1995) · Experimental Brain Research · doi:10.1007/bf00230654 · Cited by 62
Effectiveness of Gabapentin for the Treatment of Behavioral Disorders in Dementia
Herrmann, N., Lanctôt, K. L., & Myszak, M. (2000) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200002000-00015 · Cited by 61
Self-citation
Occurrence of Thrombocytopenia in Psychiatric Patients Taking Valproate
Trannel, T. J., Ahmed, I., & Goebert, D. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.1.128 · Cited by 61
NMDA, AMPA, and benzodiazepine binding site changes in Alzheimer's disease visual cortex
Carlson, M. D., Penney, J. B., & Young, A. B. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90120-z · Cited by 58
Changes in benzodiazepine receptors in alzheimer‐type dementia
Shimohama, S., Taniguchi, T., Fujiwara, M., & Kameyama, M. (1988) · Annals of Neurology · doi:10.1002/ana.410230419 · Cited by 58
Withdrawal From Controlled Carbamazepine Therapy Followed by Further Carbamazepine Treatment in Patients With Dementia
Tariot, P. N., Jakimovich, L. J., Erb, R., Cox, C., Lanning, B. D., Irvine, C., & Podgorski, C. A. (1999) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v60n1007 · Cited by 57
Recent advances in GABA research
Kardos, J. (1999) · Neurochemistry International · doi:10.1016/s0197-0186(99)00036-4 · Cited by 56
Treatment of Dementia With Behavioral Disturbance Using Divalproex or a Combination of Divalproex and a Neuroleptic
Narayan, M., & Nelson, J. C. (1997) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v58n0804 · Cited by 56
Increased .GAMMA.-aminobutyrate aminotransferase activity in brain of patients with Alzheimer's disease.
AOYAGI, T., Wada, T., Nagai, M., KOJIMA, F., HARADA, S., TAKEUCHI, T., Takahashi, H., HIROKAWA, K., & TSUMITA, T. (1990) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.38.1748 · Cited by 56
Comparison of Thioridazine and Diazepam in the Control of Nonpsychotic Symptoms Associated with Senility: Double‐Blind Study
KIRVEN, L. E., & MONTERO, E. F. (1973) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1973.tb01661.x · Cited by 55
The Effect of Diazepam Sedation on Cerebral Glucose Metabolism in Alzheimer's Disease as Measured Using Positron Emission Tomography
Foster, N. L., VanDerSpek, A. F. L., Aldrich, M. S., Berent, S., Hichwa, R. D., Sackellares, J. C., Gilman, S., & Agranoff, B. W. (1987) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1987.84 · Cited by 55
Activation of Muscarinic Receptors Inhibits औ-Amyloid Peptide-induced Signaling in Cortical Slices
Gu, Z., Zhong, P., & Yan, Z. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209892200 · Cited by 54
Divalproex sodium in the treatment of aggressive behavior and dysphoria in patients with organic brain syndromes.
Horne, M. K., & Lindley, S. E. (1995) · PubMed · Cited by 53
Treatment of Dementia-Associated Agitation With Gabapentin
Roane, D. M., Feinberg, T. E., Meckler, L., Miner, C. R., Scicutella, A., & Rosenthal, R. N. (2000) · Journal of Neuropsychiatry · doi:10.1176/jnp.12.1.40 · Cited by 53
Preserved benzodiazepine receptors in Alzheimer’s disease measured with C-11 flumazenil PET and I-123 iomazenil SPECT in comparison with CBF
Ohyama, M., Senda, M., Ishiwata, K., Kitamura, S., Mishina, M., Ishii, K., Toyama, H., Oda, K., & Katayama, Y. (1999) · Annals of Nuclear Medicine · doi:10.1007/bf03164869 · Cited by 53
Alprazolam as an Alternative to Low‐Dose Haloperidol in Older, Cognitively Impaired Nursing Facility Patients
Christensen, D. B., & Benfield, W. R. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb01081.x · Cited by 52
Effect of carbamazepine on agitation in Alzheimer's inpatients refractory to neuroleptics.
Lemke, M. R. (1995) · PubMed · Cited by 51
Alleviating Agitation, Apprehension, and Related Symptoms in Geriatric Patients
COVINGTON, J. S. (1975) · Southern Medical Journal · doi:10.1097/00007611-197506000-00015 · Cited by 50
A detailed anatomical analysis of neurotransmitter receptors in the putamen and caudate in Parkinson's disease and Alzheimer's disease
Griffiths, P. D., Perry, R. H., & Crossman, A. R. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90358-1 · Cited by 49
Carbamazepine Treatment of Agitation Associated with Dementia
Leibovici, A., & Tariot, P. N. (1988) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198878800100208 · Cited by 49
Behavioural responses of bicucculline methiodide injections into the ventral hypothalamus of freely moving, socially interacting rats
Roeling, T. A. P., Kruk, M. R., Schuurmans, R., & Veening, J. G. (1993) · Brain Research · doi:10.1016/0006-8993(93)91122-9 · Cited by 48
SCHIZOPHRENIA WITH ONSET AT THE EXTREMES OF ADULT LIFE
Castle, D. J., Wessely, S. C., Howard, R. J., & Murray, R. M. (1997) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199707)12:7 · Cited by 48
Laminar Alterations in γ‐Aminobutyric AcidA, Muscarinic, and β Adrenoceptors and Neuron Degeneration in Cingulate Cortex in Alzheimer's Disease
Vogt, B. A., Crino, P. B., & Volicer, L. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02126.x · Cited by 47
Alterations in the brain GABAA/benzodiazepine receptor-chloride ionophore complex in a genetic model of paroxysmal dystonia: A quantitative autoradiographic analysis
Nóbrega, J. N., Richter, A., Burnham, W. M., & Löscher, W. N. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00334-2 · Cited by 45
A Preliminary Study of Carbamazepine in the Treatment of Assaultive Patients With Dementia
Patterson, J. F. (1988) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198878800100105 · Cited by 45
Offense produced by chemical stimulation of the anterior hypothalamus of the rat
Adams, D. B., Boudreau, W., Cowan, C. W., Kokonowski, C., Oberteuffer, K., & Yohay, K. H. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90369-q · Cited by 44
Neurotransmitters, peptides, and neural cell adhesion molecules in the cortices of normal elderly humans and alzheimer patients: a comparison
Yew, D. T. W., Li, W., Webb, S., Lai, H. W. L., & Zhang, L. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00017-5 · Cited by 43
THE EFFECTS OF SODIUM VALPROATE ON DISTURBED BEHAVIOR IN DEMENTIA
Sival, R. C., Haffmans, P. M. J., Gent, P., Jf, V. N., & Jansen, P. A. F. (1994) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1994.tb06571.x · Cited by 43
Co-Use of Donepezil and Hypnotics Among Alzheimer's Disease Patients Living in the Community
Stahl, S. M., Markowitz, J. S., Gutterman, E. M., & Papadopoulos, G. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0418 · Cited by 43
GABA-Agonist Therapy for Alzheimerʼs Disease
Mohr, E., Bruno, G., Foster, N. L., Gillespie, M., Cox, C., Hare, T. A., Tamminga, C. A., Fedio, P., & Chase, T. N. (1986) · Clinical Neuropharmacology · doi:10.1097/00002826-198606000-00004 · Cited by 43
A Retrospective Chart Review of Gabapentin for the Treatment of Aggressive and Agitated Behavior in Patients With Dementias
Hawkins, J. W., Tinklenberg, J. R., Sheikh, J. I., Peyser, C. E., & Yesavage, J. A. (2000) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200008000-00007 · Cited by 41
Carbamazepine for assaultive patients with organic brain disease
Patterson, J. F. (1987) · Psychosomatics · doi:10.1016/s0033-3182(87)72456-6 · Cited by 40
Divalproex: a Possible Treatment Alternative for Demented, Elderly Aggressive Patients
Haas, S., Vincent, K., Holt, J., & Lippmann, S. (1997) · Annals of Clinical Psychiatry · doi:10.1023/a:1026273806909 · Cited by 38
Carbamazepine in Dementia
ESSA, M. (1986) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-198608000-00007 · Cited by 37
Low-dose oral lorazepam administration in Alzheimer subjects and age-matched controls
Sunderland, T., Weingartner, H., Cohen, R. M., Tariot, P. N., NEWHOUSE, P. A., Thompson, K., LAWLOR, B. A., & Mueller, E. A. (1989) · Psychopharmacology · doi:10.1007/bf00634466 · Cited by 37
Zolpidem for Dementia-Related Insomnia and Nighttime Wandering
Shelton, P. S., & Hocking, L. B. (1997) · Annals of Pharmacotherapy · doi:10.1177/106002809703100309 · Cited by 35
A selective reduction of excitatory amino acids in cerebrospinal fluid of patients with Alzheimer type dementia compared with vascular dementia of the Binswanger type
Tohgi, H., Abe, T., Takahashi, S., & Kimura, M. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90321-w · Cited by 33
Laboratory examinations correlated with severity of dementia.
Oishi, M., Mochizuki, Y., Yoshihashi, H., Takasu, T., & Nakano, E. (1996) · PubMed · Cited by 32
Agitation in the Demented Elderly
Ancill, R. J., Carlyle, W., LIANG, R. A., & Holliday, S. G. (1991) · International Clinical Psychopharmacology · doi:10.1097/00004850-199100630-00002 · Cited by 31
GABA transporters (GAT-1) in Alzheimer's disease
Nägga, K., Bogdanović, N., & Marcusson, J. O. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050230 · Cited by 31
Carbamazepine for aggressive agitation in demented patients during nursing care
Marin, D. B., & GREENWALD, B. S. (1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.6.805 · Cited by 31
Valproic Acid for Physically Aggressive Behavior in Geriatric Patients
Sandborn, W. D., Bendfeldt, F., & Hamdy, R. C. (1995) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-199522330-00007 · Cited by 30
Psychotropic Drug Utilization in Long-Term-Care Facilities for the Elderly in Ontario, Canada
Conn, D. K., Ferguson, I., Mandelman, K., & Ward, C. (1999) · International Psychogeriatrics · doi:10.1017/s1041610299005797 · Cited by 29
Comparison of iodine-123-iomazenil SPECT and technetium-99m-HMPAO-SPECT in Alzheimer's disease.
Fukuchi, K., Hashikawa, K., Seike, Y., Moriwaki, H., Oku, N., Ishida, M., Fujita, M., Uehara, T., Tanabe, H., Kusuoka, H., et al. (1997) · PubMed · Cited by 29
EVALUATION OF OXAZEPAM AND PLACEBO IN EMOTIONALLY DISTURBED AGED PATIENTS.
Jf, S. (1965) · PubMed · Cited by 29
Neurochemical Bases of Aggressive Behavior
Eichelman, B. S. (1987) · Psychiatric Annals · doi:10.3928/0048-5713-19870601-07 · Cited by 28
GABA-Transaminase in brain and blood platelets: Basic and clinical aspects
Sherif, F. M. (1994) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(94)90089-2 · Cited by 27
Divalproex: a Possible Treatment Alternative for Demented, Elderly Aggressive Patients
Haas, S., Vincent, K., Holt, J., et al. (1997) · Annals of Clinical Psychiatry · doi:10.3109/10401239709147789 · Cited by 27
Gamma-aminobutyric acid (GABA) in cerebrospinal fluid.
Kuroda, H. (1983) · PubMed · doi:10.18926/amo/32437 · Cited by 26
Valproate-Associated Dysmyelopoiesis in Elderly Patients
So, C. C., & Wong, K.-F. (2002) · American Journal of Clinical Pathology · doi:10.1309/4tef-lvgx-weq9-r8w8 · Cited by 24
Management of behavior in the institutionalized aged.
Cr, B. (1965) · PubMed · Cited by 23
GABA and brain abnormalities in schizophrenia
van Kammen, D. (1998) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(98)00006-7 · Cited by 21
Case Report of Carbamazepine Treatment of Organic Brain Syndrome with Psychotic Features
ANTON, R. F., Waid, L. R., Fossey, M. D., & AuBuchon, P. G. (1986) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-198608000-00006 · Cited by 19
Clonazepam Treatment of Multi-infarct Dementia
Smeraski, P. J. (1988) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198878800100108 · Cited by 19
Effects of psychotherapeutic drugs on hypothalamic-induced hissing in cats
Funderburk, W. H., Foxwell, M. H., & Hakala, M. W. (1970) · Neuropharmacology · doi:10.1016/0028-3908(70)90042-0 · Cited by 18
Clonazepam treatment of organic brain syndromes in three elderly patients.
Jp, F., & Alvarez, W. A. (1986) · PubMed · Cited by 18
Striatal Expression of Glutamic Acid Decarboxylase Gene in Alzheimer's Disease
Boissière‐Michot, F., Faucheux, B. A., Duyckaerts, C. J., Hauw, J., Agid, Y., & Hirsch, É. C. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71020767.x · Cited by 16
CSF GABA in caregiver spouses of Alzheimer patients
Pomara, N., Deptula, D., Galloway, M. P., LeWitt, P. A., & Stanley, M. (1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.6.787 · Cited by 16
Cerebrospinal fluid and plasma gamma-aminobutyric acid in Alzheimer's disease
Weiner, M., Speciale, S. G., Risser, R. C., Kramer, G. L., & Petty, F. (1996) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00305-8 · Cited by 15
A Single-Case-Study Method for Treating Resistiveness in patients with Alzheimer's Disease
Herz, L. R., Volicer, L., Ross, V. H., & Rheaume, Y. (1992) · Psychiatric Services · doi:10.1176/ps.43.7.720 · Cited by 14
Neurotransmitter receptor imaging in Alzheimer's disease.
Sedvall, G., Nybäck, H., Farde, L., & Persson, A. (1987) · PubMed · Cited by 14
Pharmacology of recombinant human GABAA receptor subtypes measured using a novel pH-based high-throughput functional efficacy assay
Simpson, P. B., Woollacott, A. J., Pillai, G. V., Maubach, K. A., Hadingham, K. L., Martin, K., Choudhury, H., & Seabrook, G. R. (2000) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(00)00219-3 · Cited by 12
Cerebellar GABAA receptors and anxiolytic action of diazepam
Vekovischeva, O. Y., Haapalinna, A., Sarviharju, M., Honkanen, A., & Korpi, E. R. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01691-1 · Cited by 12
Glutamate and GABA levels in CSF from patients affected by dementia and olivo-ponto-cerebellar atrophy
Tosca, P., Canevari, L., Paolo, E. D., Ferrari, R., Verzé, S., Zerbi, F., & Dagani, F. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1992.tb06042.x · Cited by 11
Clonazepam for Agitated Patients with Alzheimer's Disease
Ginsburg, M. L. (1991) · The Canadian Journal of Psychiatry · doi:10.1177/070674379103600329 · Cited by 9
Effects of a choline acetyltransferase inhibitor on self-stimulatory behavior in the rat.
Jb, M., & Me, G. (1970) · PubMed · Cited by 5
Brain aminobutyrate aminotransferase activity in Alzheimer's disease.
Sherif, F. M., Ss, A., & Eriksson, L. G. (1995) · PubMed · Cited by 4
Lorazepam treatment of resistive aggression in dementia
Fritz, J., & Stewart, J. T. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.9.1250a · Cited by 4
Senile Dementia and Presenile Dementia
Nakamura, S. (1990) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.161.supplement_49 · Cited by 2
[Anticonvulsants in agitation and behavior disorders in demented subjects. Report of 8 cases].
Fahs, H., Potiron, G., Senon, J., & Perivier, E. (1999) · PubMed · Cited by 2

Flagged first, then by citations

Research works printed but not linked: 22

Canadian Study of Health and Aging Working Group, 1994, Can Med Assoc J, 150, 899
Malick JB, 1970, Arch Int Pharmacodyn Ther, 184, 252
Delgado JMR, 1973, Antiaggressive effects of chlordiazepoxide
Sedvall G, 1987, J Neural Transm Suppl, 24, 43
Sherif F, 1995, Neurodegeneration, 4, 114
Fukuchi K, 1997, J Nucl Med, 38, 467
Wyper D, 1998, Inter J Geriatr Psychopharmacol, 1, 126
Oishi M, 1996, Ann Clin Lab Sci, 26, 340
Kuroda H., 1983, Acta Med Okayama, 37, 167
Bareggi SR, 1982, Age or disease-related modifications? Arch Neurol, 39, 709
Freinhar JP, 1986, J Clin Psychiatry, 47, 525
Fritz J, 1990, Am J Psychiatry, 147
Sanders JF, 1965, Geriatrics, 20, 739
Beber CR, 1965, Dis Nerv Syst, 26, 591
Chesrow EJ, 1965, Clin Med, 71, 1001
Herz LR, 1992, Hosp Community Psychiatry, 43, 720
Marin DB, 1989, Am J Psychiatry, 146
Lemke MR, 1995, J Clin Psychiatry, 56, 354
Gleason RP, 1990, J Clin Psychiatry, 51, 115
Gupta S, 1998, Int J Geriatr Psychopharmacol, 1, 244
Fahs H, 1999, Encephale, 25, 169
Horne M, 1995, J Clin Psychiatry, 56, 430

Sorted by citations

The Gut Microbiota and Alzheimer’s Disease
Jiang, C., Li, G., Huang, P., Liu, Z., & Zhao, B. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161141 · Cited by 852
“Postmortem studies of the cortical areas of AD patients have shown reduced frontal, temporal, and parietal GABA concentrations (for review, see [58]).”
Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer’s disease Neurons
Rajmohan, R., & Reddy, P. H. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160612 · Cited by 730
“Because ofthis,stimulatingGABAergictransmissionhas beenattemptedtotreatbehavioralandpsychologi-caldysfunctionsinAD[52,61],buttheseeffortsare limitedduetoissuesoftoleranceafterlong-termuse andsideeffects[52,62].”
Alzheimer’s disease and gut microbiota
Hu, X., Wang, T., & Jin, F. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-5083-9 · Cited by 371
The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology
Doifode, T., Giridharan, V. V., Generoso, J. S., Bhatti, G., Collodel, A., Schulz, P. E., Forlenza, O. V., & Barichello, T. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105314 · Cited by 347
Loss of functional GABA A receptors in the Alzheimer diseased brain
Limón, A., Reyes‐Ruiz, J. M., & Miledi, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204606109 · Cited by 275
“Early studies of the temporal cortex, an area greatly affected by the neuropathic hallmarks of AD, showed only slight decreases (13–17%) of benzodiazepine binding (2, 5), suggesting a modest decrease of GABAARs in AD.”
Background

See all 199

Authors: Lanctôt, K. L., Herrmann, N., Mazzotta, P., Khan, L. R., & Ingber, N.
Affiliations: Sunnybrook Health Science Centre (CA)
Corresponding author: Lanctôt, Krista L
ORCID: Lanctôt, Krista L
Herrmann, Nathan
Venue: The Canadian Journal of Psychiatry
Publisher: SAGE Publications
Published: 2004-07
Volume: 49
Issue: 7
Pages: 439-453
ISSN: 0706-7437 (ISSN-L)
1497-0015
DOI: 10.1177/070674370404900705
OpenAlex: W2184602814
Cited by: 191
References: 146
Citations by year: 2025: 7 · 2024: 6 · 2023: 6 · 2022: 11 · 2021: 14 · 2020: 12 · 2019: 13 · 2018: 19 · 2017: 15 · 2016: 11 · 2015: 9 · 2014: 8 · 2013: 9 · 2012: 6
FWCI: 3.09
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: The Canadian Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: Alzheimer's Society
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: Alzheimer's disease, GABA, GABAergic dysfunction, behavioral and psychological symptoms of dementia, inhibitory neurotransmitter, GABAergic drugs, anxiolytics, antiepileptic drugs, disease subtypes
MeSH terms: Aged, Alzheimer Disease, Benzodiazepines, Binding Sites, Brain, Frontal Lobe, gamma-Aminobutyric Acid, Humans, Limbic System, Parietal Lobe, Temporal Lobe, Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon, Receptors, GABA, GABA Agonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

GABAergic Function in Alzheimer's Disease: Evidence for Dysfunction and Potential as a Therapeutic Target for the Treatment of Behavioural and Psychological Symptoms of Dementia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks