The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Using the Nematode Caenorhabditis Elegans To Predict Mammalian Acute Lethality To Metallic Salts
Abstract
The acute lethality of the salts of eight metals-HgCl 2, BeSO 4.4H 2 O, Al(NO 3)3-9H 2 O, CuCl2-2H2O, ZnCl 2, Pb(NO 3)2, CdCl2, and Sr(NO3)2-was determined using a type of free-living nematode, Caenorhabditis elegans. The LC50 values were compared to the published mammalian oral LDso values for salts of the same metals. Within this set of chemicals, C. elegans was found to be a predictor of mammalian acute lethality, generating LC50 values parallel to the rat and mouse LD50 values. The total expenses for this testing are about 10% of the cost for mammalian acute lethality testing. The method is considered to have great promise, but further study is needed.
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Citations
Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589
The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
Cited by
The C. elegans model in toxicity testing
Hunt, P. R. (2017) · Journal of Applied Toxicology · doi:10.1002/jat.3357 · Cited by 585
Egorova, K. S., & Ananikov, V. P. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201603777 · Cited by 490
Aquatic toxicity testing using the nematode,Caenorhabditis elegans
Williams, P. L., & Dusenbery, D. B. (1990) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620091007 · Cited by 447
Self-citationAntifungal Chemical Compounds Identified Using a C. elegans Pathogenicity Assay
Breger, J., Fuchs, B. B., Aperis, G., Moy, T. I., Ausubel, F. M., & Mylonakis, E. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030018 · Cited by 332
Chen, X., Nam, S.-W., Jou, M. J., Kim, Y., Kim, S.-J., Park, S., & Yoon, J. (2008) · Organic Letters · doi:10.1021/ol8022598 · Cited by 301
Metadata
- Authors
- Williams, P. L., & Dusenbery, D. B.
- Venue
- Toxicology and Industrial Health
- Publisher
- SAGE Publications
- Published
- 1988-10
- Volume
- 4
- Issue
- 4
- Pages
- 469-478
- ISSN
- 0748-2337 (ISSN-L)
- 1477-0393
- OpenAlex
- W1996418402
- Cited by
- 205
- References
- 2
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Using the Nematode Caenorhabditis Elegans To Predict Mammalian Acute Lethality To Metallic Salts. https://app.cochat.ai/papers/10.1177/074823378800400406
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- Williams, P. L., & Dusenbery, D. B. (1988). Using the Nematode Caenorhabditis Elegans To Predict Mammalian Acute Lethality To Metallic Salts. Toxicology and Industrial Health. https://doi.org/10.1177/074823378800400406
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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