An Evaluation of the Effect of Increasing Parental Age on the Phenotypic Severity of Autism Spectrum Disorder
Open accessAbstract
It was recently postulated that because increased genetic load and increased parental age are both purportedly associated with the risk to develop an autism spectrum disorder, there must be a linkage between increasing genetic load and increasing parental age in autism spectrum disorder pathogenesis. The present study examined the hypothesis that if increased genetic load from increasing paternal age is important to autism spectrum disorder pathogenesis, then there should be a significant relationship between increasing parental age and increasing autism spectrum disorder phenotypic severity. Outpatient clinical records were retrospectively examined to identify a consecutive cohort of subjects diagnosed with an autism spectrum disorder (n = 351). Increasing autism spectrum disorder phenotypic severity was found not to be associated with increasing maternal/paternal age. The present study failed to support the hypothesis that increasing parental age was associated with increasing autism spectrum disorder phenotypic severity, but future studies should examine the relationship between genetic mutations in subjects diagnosed with an autism spectrum disorder and increasing parental age.
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Diverse environmental factors have been implicated as risk factors for ASD, including maternal stress and drug use, paternal age, nutritional status, hormones, and environmental chemicals.
“Diverse environmental factors have been implicated as risk factors for ASD, including maternal stress and drug use, paternal age, nutritional status, hormones, and environmental chemicals [ 14 , 25–29 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [28]
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Keil, K. P., & Lein, P. J. (2016) · Environmental Epigenetics · doi:10.1093/eep/dvv012 · Cited by 167 · see citing works
Severity of Autism Spectrum Disorders: Current Conceptualization, and Transition to DSM-5
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- Authors
- Geier, D. A., Hooker, B. S., Kern, J. K., Sykes, L. K., & Geier, M. R.
- Affiliations
- The Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
- Simpson University (US)
- CoMeD, Inc, Silver Spring, MD, USA
- Corresponding author
- Geier, Mark R.
- Venue
- Journal of Child Neurology
- Publisher
- SAGE Publications
- Published
- 2016-07-20
- ISSN
- 0883-0738 (ISSN-L)
- 1708-8283
- OpenAlex
- W2161141814
- Cited by
- 7
- References
- 11
- Citations by year
- 2021: 1 · 2019: 1 · 2017: 1 · 2016: 3 · 2015: 1
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Update notices
- correction (2016-11-25)
- Open access
- hybrid
- doi.org
- Locations
- Journal of Child Neurology (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
- Keywords
- autism spectrum disorder, parental age, paternal age, maternal age, phenotypic severity, genetic load, autism pathogenesis, genetic mutations
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