Multixnodality Evoked Potential Findings in Infants With Congenital Heart Defects
Abstract
Evoked potentials are sensitive prognostic tools in young infants at risk for developmental disability. The objective of this prospective study was to determine whether infants with congenital heart defects demonstrate evoked potential abnormalities prior to or following open heart surgery, and to examine the association between these abnormalities and developmental status 1 year following surgery. A consecutive series of newborns (less than 1 month old) and infants (1 month to 2 years old) were recruited. Somatosensory and brain stem auditory evoked potentials were carried out before or after cardiac surgery, or both. One year later, neurologic examination and standardized measures of motor performance and functional independence were carried out. Twenty-seven newborns and 31 infants underwent perioperative somatosensory evoked potential recordings. Results indicate that perioperative somatosensory evoked potential abnormalities were common in newborns (41%) but not in infants (13%) with congenital heart defects. Brainstem conduction times were within normal limits in all subjects; however, 32% presented with mild elevations in hearing thresholds. All newborns with abnormal somatosensory evoked potentials had abnormal neurologic examinations both perioperatively and again 1 year after open heart surgery. Moreover, standardized developmental assessments 1 year following surgery indicate that all newborns with somatosensory evoked potential abnormalities had developmental deficits in one or more domains. Somatosensory evoked potential abnormalities in the perioperative period are common in newborns with congenital heart defects, and are strongly predictive of persistent developmental delay later. ( J Child Neurol 1999;14:702-707).
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Adverse neurodevelopmental outcomes in children with complex congenital heart disease are due not only to perioperative insult but also to inborn factors.
“However, there is increasing evidence that adverse neurodevelopmental outcomes in children with complex CHD are due not only perioperative insult, but to inborn factors as well.”
From Brain Volume and Metabolism in Fetuses With Congenital Heart Disease: Evaluation With Quantitative Magnetic Resonance Imaging and Spectroscopy (2010) · cites this paper as [9]
A high prevalence of anatomic and functional neurologic abnormalities has been documented before surgery in newborns with congenital heart disease, and such abnormalities are associated with childhood developmental status.
“Reports from a number of investigators have documented a high prevalence of anatomic and functional neurologic abnormalities prior to surgery in newborns with CHD [9-17], and an association of such abnormalities with childhood developmental status [11,13,18,19].”
From Brain Volume and Metabolism in Fetuses With Congenital Heart Disease: Evaluation With Quantitative Magnetic Resonance Imaging and Spectroscopy (2010) · cites this paper as [9]
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Limperopoulos, C., Tworetzky, W., McElhinney, D. B., Newburger, J. W., Brown, D. W., Robertson, R. L., Guizard, N., McGrath, E., Geva, J., Annese, D., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.865568 · Cited by 663 · see citing works
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Self-citation
- Authors
- Limperopoulos, C., Majnemer, A., Rosenblatt, B., Shevell, M., Rohlicek, C., & Tchervenkov, C.
- Affiliations
- Montreal Children's Hospital (CA)
- Corresponding author
- Majnemer, Annette
- Venue
- Journal of Child Neurology
- Publisher
- SAGE Publications
- Published
- 1999-11
- Volume
- 14
- Issue
- 11
- Pages
- 702-707
- ISSN
- 0883-0738 (ISSN-L)
- 1708-8283
- OpenAlex
- W2008209000
- Cited by
- 19
- References
- 29
- Citations by year
- 2024: 2 · 2022: 1 · 2020: 1 · 2014: 1 · 2012: 2
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Health Canada
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
- Keywords
- congenital heart disease, somatosensory evoked potentials, auditory brainstem response, open heart surgery, developmental delay, neurodevelopmental outcomes, neonates, infants, hearing threshold, prognostic factors
- MeSH terms
- Brain, Developmental Disabilities, Evoked Potentials, Somatosensory, Female, Follow-Up Studies, Heart Defects, Congenital, Humans, Infant, Infant, Newborn, Male, Motor Skills, Neurologic Examination, Predictive Value of Tests, Prospective Studies, Sensitivity and Specificity, Social Behavior, Evoked Potentials, Auditory, Brain Stem
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