The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Phase Angle as a Prognostic Marker in Patients With Critical Illness
Abstract
Background: Phase angle (PA) is interpreted as an indicator of cell membrane integrity and a prognostic indicator in some clinical situations. This study aims to evaluate PA as a prognostic marker in critically ill patients admitted to the intensive care unit (ICU) and associate this marker with length of hospital stay, mortality, and clinical scores. Methods: A cohort study was conducted with 95 patients aged ≥18 years admitted to the ICU, who were assessed in terms of prognostic indexes (Acute Physiology and Chronic Health Evaluation II [APACHE II] and Sequential Organ Failure Assessment [SOFA]), clinical evolution (ICU discharge, death, and length of ICU stay), and PA. Results: Patients were predominantly male (63.1%) and had a mean age of 63.7 ± 14.6 years; length of stay of 4 days (range, 3–9 days); mortality of 15.8%; mean APACHE II and SOFA scores of 17.3 ± 8.2 and 6.1 ± 3.1 points, respectively; and mean PA of 4.91 ± 1.36°. An association was observed between females and PA <5.1° (P = .035), which was the cutoff point determined from the receiver operating characteristic curve. PA was correlated with APACHE II score (r = −0.241; P = .02). This correlation became moderate only when patients without sepsis were considered (r = −0.506; P < .001). Conclusions: PA seems to be a good prognostic marker for patients without sepsis. The weak correlation between PA and APACHE II score and the lack of association with other clinical outcomes are limitations for interpreting the prognostic value of PA in the entire study sample.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Several studies have described the advantages of bio impedance (36,37,38,39) and mainly phase angle (40) in the evaluation of the prognosis of critically ill patients.”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [37]
Citations
Cites
APACHE II: A severity of disease classification system
KNAUS, W. A., DRAPER, E. A., WAGNER, D. P., & ZIMMERMAN, J. E. (1985) · Critical Care Medicine · doi:10.1097/00003246-198510000-00009 · Cited by 13,664
APACHE II-A Severity of Disease Classification System: Reply
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,376
Vincent, J. L., Moreno, R., Takala, J., Willatts, S., De Mendonça, A., Bruining, H., Reinhart, C. K., Suter, P. M., & Thijs, L. G. (1996) · Intensive Care Medicine · doi:10.1007/bf01709751 · Cited by 11,674
Early goal-directed therapy in the treatment of severe sepsis and septic shock
Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743
Bioelectrical impedance analysis?part I: review of principles and methods
KYLE, U. (2004) · Clinical Nutrition · doi:10.1016/j.clnu.2004.06.004 · Cited by 3,200
Multiple Organ Dysfunction Score: A reliable descriptor of a complex clinical outcome
Marshall, J. C., Cook, D. J., Christou, N. V., Bernard, G. R., Sprung, C. L., & Sibbald, W. J. (1995) · Critical Care Medicine · doi:10.1097/00003246-199510000-00007 · Cited by 2,532
APACHE—acute physiology and chronic health evaluation: a physiologically based classification system
KNAUS, W. A., ZIMMERMAN, J. E., WAGNER, D. P., DRAPER, E. A., & LAWRENCE, D. E. (1981) · Critical Care Medicine · doi:10.1097/00003246-198108000-00008 · Cited by 2,189
A simplified acute physiology score for ICU patients
GALL, J.-R. L., LOIRAT, P., ALPEROVITCH, A., GLASER, P., GRANTHIL, C., MATHIEU, D., MERCIER, P., THOMAS, R., & VILLERS, D. (1984) · Critical Care Medicine · doi:10.1097/00003246-198411000-00012 · Cited by 1,251
Therapeutic intervention scoring system: a method for quantitative comparison of patient care
CULLEN, D. J., CIVETTA, J. M., BRIGGS, B. A., & FERRARA, L. C. (1974) · Critical Care Medicine · doi:10.1097/00003246-197403000-00001 · Cited by 1,200
Norman, K., Stobäus, N., Pirlich, M., & Bosy-Westphal, A. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.05.008 · Cited by 1,049
Research works printed but not linked: 4
- Waitzberg DL, 2011, Revisión desnutrición hospitalaria, Nutr Hosp, 26, 254
- GIBI Brazilian Group for Bioimpedance Study, 1995, Total body bioelectrical impedance measurement as a progressive outcome prediction and therapeutic index in the comparison between septic and non septic patients. A multicenter Brazilian study, Rev Metab Nutr, 2, 159
- Miranda AMM, 2010, Ângulo de Fase Como Indicador de Prognóstico em Doentes Críticos com Sépsis
- 10.1093/ajcn/82.1.49 · DOI · Paper page
Cited by
ESPEN guideline on clinical nutrition in the intensive care unit.
Singer, P., Blaser, A. R., Berger, M. M., Alhazzani, W., Calder, P. C., Casaer, M. P., Hiesmayr, M., Mayer, K., Montejo, J. C., Pichard, C., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.08.037 · Cited by 2,904
Phase angle and mortality: a systematic review
Garlini, L. M., Alves, F. D., Ceretta, L. B., Perry, I. S., Souza, G. C., & Clausell, N. O. (2019) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0159-1 · Cited by 277
Self-citationComprehensive metabolic amino acid flux analysis in critically ill patients
Deutz, N. E. P., Singer, P., Wierzchowska-McNew, R. A., Viana, M. V., Ben-David, I. A., Pantet, O., Thaden, J. J., Ten Have, G. A. M., Engelen, M. P. K. J., & Berger, M. M. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.03.015 · Cited by 47
Metadata
- Authors
- da Silva, T. K., Berbigier, M. C., Rubin, B. D. A., Moraes, R. B., Corrêa Souza, G., & Schweigert Perry, I. D.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Venue
- Nutrition in Clinical Practice
- Publisher
- Wiley
- Published
- 2015-03-31
- Volume
- 30
- Issue
- 2
- Pages
- 261-265
- ISSN
- 0884-5336 (ISSN-L)
- 1941-2452
- OpenAlex
- W1963691037
- Cited by
- 82
- References
- 36
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 8 · 2022: 16 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 12 · 2017: 6 · 2016: 3 · 2015: 1
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- onlinelibrary.wiley.com/termsAndConditions#vor (vor)
- journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
- Locations
- Nutrition in Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- phase angle, prognostic factors, critical illness, intensive care unit, sepsis, APACHE II score, SOFA score, mortality, length of hospital stay, plasma membrane integrity, bioelectrical impedance analysis, nutritional status
- MeSH terms
- Aged, Body Composition, Female, Humans, Intensive Care Units, Length of Stay, Male, Middle Aged, Plethysmography, Impedance, Prognosis, Risk Factors, Sex Factors, Cohort Studies, Biomarkers, Critical Illness, Electric Impedance, APACHE, Organ Dysfunction Scores
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Phase Angle as a Prognostic Marker in Patients With Critical Illness. https://app.cochat.ai/papers/10.1177/0884533615572150
- The paper
- da Silva, T. K., Berbigier, M. C., Rubin, B. D. A., Moraes, R. B., Corrêa Souza, G., & Schweigert Perry, I. D. (2015). Phase Angle as a Prognostic Marker in Patients With Critical Illness. Nutrition in Clinical Practice. https://doi.org/10.1177/0884533615572150
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
