The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Very Early Detection of Alzheimer Neuropathology and the Role of Brain Reserve in Modifying Its Clinical Expression
Open accessAbstract
Numerous studies show that the pathology of Alzheimer’s disease is present decades before a clinical diagnosis of dementia can be made. Given the likelihood that agents will become available that reliably delay onset and/or slow progression of Alzheimer’s disease, it will be important to detect preclinical Alzheimer’s disease as early as possible for maximal treatment effect. Detection of individuals by sensitive cognitive measures provides one way to identify people who are at high risk of developing clinical Alzheimer’s disease. However, it is likely that those with considerable brain or cognitive reserve will be able to mask cognitive deficits until very close to the onset of the dementia, rendering such cognitive measures insensitive. Optimum biomarkers for Alzheimer’s disease therefore need to target the severity of underlying brain pathology independently of brain reserve. Findings are presented showing the importance of higher education and larger brain size in masking the underlying disease pathology.
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Cites
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Cited by
Neuropathology of older persons without cognitive impairment from two community-based studies
Bennett, D. A., Schneider, J. A., Arvanitakis, Z., Kelly, J. F., Aggarwal, N. T., Shah, R. C., & Wilson, R. S. (2006) · Neurology · doi:10.1212/01.wnl.0000219668.47116.e6 · Cited by 1,336
APOE predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging
Morris, J. C., Roe, C. M., Xiong, C., Fagan, A. M., Goate, A. M., Holtzman, D. M., & Mintun, M. A. (2010) · Annals of Neurology · doi:10.1002/ana.21843 · Cited by 830
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The relationship between obesity and cognitive health and decline
Dye, L., Boyle, N. B., Champ, C., & Lawton, C. (2017) · Proceedings of the Nutrition Society · doi:10.1017/s0029665117002014 · Cited by 469
Metadata
- Authors
- Mortimer, J. A., Borenstein, A. R., Gosche, K. M., & Snowdon, D. A.
- Venue
- Journal of Geriatric Psychiatry and Neurology
- Publisher
- SAGE Publications
- Published
- 2005-12
- Volume
- 18
- Issue
- 4
- Pages
- 218-223
- ISSN
- 0891-9887 (ISSN-L)
- 1552-5708
- OpenAlex
- W2066496754
- Cited by
- 188
- References
- 19
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Mortimer, J. A., Borenstein, A. R., Gosche, K. M., & Snowdon, D. A. (2005). Very Early Detection of Alzheimer Neuropathology and the Role of Brain Reserve in Modifying Its Clinical Expression. Journal of Geriatric Psychiatry and Neurology. https://doi.org/10.1177/0891988705281869
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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