Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia

Jack, C. R.; Dickson, D. W.; Parisi, J. E.; Xu, Y. C.; Cha, R. H.; O’Brien, P. C.; Edland, S. D.; Smith, G. E.; Boeve, B. F.; Tangalos, E. G.; Kokmen, E.; Petersen, R. C.

doi:10.1212/wnl.58.5.750

Cited by 610Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia

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Jack, C. R., Dickson, D. W., Parisi, J. E., Xu, Y. C., Cha, R. H., O’Brien, P. C., Edland, S. D., Smith, G. E. +4 more·2002·Neurology

DOI 10.1212/wnl.58.5.750PMC PMC2745935

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Abstract

OBJECTIVES: To assess the diagnostic specificity of MRI-defined hippocampal atrophy for AD among individuals with a variety of pathologically confirmed conditions associated with dementia as well as changes attributable to typical aging, and to measure correlations among premortem MRI measurements of hippocampal atrophy, mental status examination performance, and the pathologic stage of AD. METHODS: An unselected series of 67 individuals participating in the Mayo Alzheimer's Disease Research Center/Alzheimer's Disease Patient Registry who had undergone a standardized antemortem MRI study and also postmortem examination were identified. Hippocampal volumes were measured from antemortem MRI. Each postmortem specimen was assigned a pathologic diagnosis and in addition, the severity of AD pathology was staged using the method of Braak and Braak. RESULTS: Individuals with an isolated pathologic diagnosis of AD, hippocampal sclerosis, frontotemporal degeneration, and neurofibrillary tangle--only degeneration usually had substantial hippocampal atrophy, while those with changes of typical aging did not. Among all 67 subjects, correlations (all p < 0.001) were observed between hippocampal volume and Braak and Braak stage (r = -0.39), between hippocampal volume and Mini-Mental State Examination (MMSE) score (r = 0.60), and between MMSE score and Braak and Braak stage (r = -0.41). CONCLUSIONS: Hippocampal atrophy, while not specific for AD, was a fairly sensitive marker of the pathologic AD stage (particularly among subjects with isolated AD pathology [r = -0.63, p = 0.001]) and consequent cognitive status.

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Antemortem MRI has previously been found to correlate well with measures of cognitive deterioration and post-mortem Braak staging of Alzheimer's disease.
“As well as revealing signs of atrophy, which can inform differential diagnosis of the disease, antemortem MRI has previously been found to correlate well with measures of cognitive deterioration and post-mortem Braak staging of the disease (Csernansky et al., 2004, Jack et al., 2002, Vemuri et al., 2008, Whitwell et al., 2008).”
From In vivo imaging of tau pathology using multi-parametric quantitative MRI (2015) · cites this paper as Jack et al., 2002
Hippocampal atrophy is a major feature of Alzheimer's disease and strongly correlates with AD neuropathology.
“Hippocampal atrophy is a major feature of Alzheimer's disease (AD) (Frisoni et al., 2010) that strongly correlates with AD neuropathology (Bobinski et al., 1996; Jack et al., 2002).”
From Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia (2013) · cites this paper as Jack et al., 2002
Raw volumes of each hippocampal subfield and of the whole hippocampus were normalized by total intracranial volume and transformed into age- and gender-adjusted W-scores.
“Raw volumes of each hippocampal subfield and of the whole hippocampus (corresponding to the sum of the three subfields) were first normalized by the TIV to account for inter-individual variability in head size (normalized volume = 1000 × raw volume / TIV) and then transformed into W-scores, i.e. age and gender-adjusted Z-scores (Jack et al., 2002).”
From Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia (2013) · cites this paper as Jack et al., 2002

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Authors: Jack, C. R., Dickson, D. W., Parisi, J. E., Xu, Y. C., Cha, R. H., O’Brien, P. C., Edland, S. D., Smith, G. E., Boeve, B. F., Tangalos, E. G., Kokmen, E., & Petersen, R. C.
Affiliations: Mayo Clinic (US)
ORCID: Jack, C. R.
Dickson, D. W.
O’Brien, P. C.
Edland, S. D.
Smith, G. E.
Boeve, B. F.
Petersen, R. C.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2002-03-12
Volume: 58
Issue: 5
Pages: 750-757
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.58.5.750
PMC: PMC2745935
OpenAlex: W2089588548
Cited by: 610
References: 44
Citations by year: 2026: 20 · 2025: 12 · 2024: 21 · 2023: 20 · 2022: 20 · 2021: 19 · 2020: 15 · 2019: 25 · 2018: 16 · 2017: 23 · 2016: 21 · 2015: 30 · 2014: 25 · 2013: 35 · 2012: 31
FWCI: 16.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5r01ns029059-03)
National Institute on Aging (AG-06786, AG 16574, U01AG006786, R01AG011378, AG-11378, R37AG011378, P50AG016574)
National Institute of Neurological Disorders and Stroke (NS 29059)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: hippocampal atrophy, Alzheimer's disease, Braak staging, hippocampal volume, dementia, hippocampal sclerosis, frontotemporal lobar degeneration, neurofibrillary tangles, Mini-Mental State Examination, diagnostic specificity, postmortem brain examination
MeSH terms: Aged, Aged, 80 and over, Aging, Alzheimer Disease, Dementia, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Sensitivity and Specificity, Statistics as Topic

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Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia

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