The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Tetracyclines Inhibit Connective Tissue Breakdown: New Therapeutic Implications for an Old Family of Drugs
Abstract
Tetracyclines have long been considered useful adjuncts in peridontal therapy based on their antimicrobial efficacy against putative periodontopathogens. However, recently these drugs were found to inhibit mammalian collagenases and several other matrix metalloproteinases (MMPs) by a mechanism independent of their antimicrobial activity. Evidence is presented that this property may be therapeutically useful in retarding pathologic connective tissue breakdown, including bone resorption. The experiments leading to this discovery are described and possible mechanisms are addressed, including the specificity of tetracyclines' anti-collagenase activity, the role of the drugs' metal ion (Zn2+, Ca 2+)- binding capacity, and the site on the tetracycline molecule responsible for this nonantimicrobial property. Of extreme interest, the tetracycline molecule has been chemically modified in multiple ways, generating a new family of compounds called CMTs (chemically modified tetracyclines) that lack antimicrobial but still retain anti-collagenase activity. The first of these CMTs, 4-de-dimethylaminotetracycline, was found not to produce a major side-effect of antimicrobial tetracycline therapy- its administration to experimental animals did not result in the emergence of tetracycline-resistant microorganisms in the oral flora and gut. Numerous examples of the clinical potential of this non-antimicrobial property of tetracyclines in the treatment of periodontal and several medical diseases (e.g., sterile corneal ulcers, rheumatoid arthritis, skin bullous lessions, tumor-induced angiogenesis and metastasis) are discussed.
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Cites
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Self-citationDefective polymorphonuclear leukocyte function in a human periodontal disease
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Golub, L. M., Ramamurthy, N., McNamara, T. F., Gomes, B., Wolff, M., Casino, A., Kapoor, A., Zambon, J., Ciancio, S., Schneir, M., et al. (1984) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1984.tb01334.x · Cited by 313
Self-citationA Non-antibacterial Chemically-modified Tetracycline Inhibits Mammalian Collagenase Activity
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Cited by
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
Yrjänheikki, J., Keinänen, R., Pellikka, M., Hökfelt, T., & Koistinaho, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15769 · Cited by 1,006
Minocycline: Far beyond an Antibiotic
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Matrix Metalloproteinases As Novel Biomarker s and Potential Therapeutic Targets in Human Cancer
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Metal Complexes as Enzyme Inhibitors
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Metadata
- Authors
- Golub, L. M., Ramamurthy, N. S., McNamara, T. F., Greenwald, R. A., & Rifkin, B. R.
- Venue
- Critical Reviews in Oral Biology & Medicine
- Publisher
- SAGE Publications
- Published
- 1991-07
- Volume
- 2
- Issue
- 3
- Pages
- 297-321
- ISSN
- 1045-4411 (ISSN-L)
- 1544-1113
- OpenAlex
- W1938535455
- Cited by
- 522
- References
- 37
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Golub, L. M., Ramamurthy, N. S., McNamara, T. F., Greenwald, R. A., & Rifkin, B. R. (1991). Tetracyclines Inhibit Connective Tissue Breakdown: New Therapeutic Implications for an Old Family of Drugs. Critical Reviews in Oral Biology & Medicine. https://doi.org/10.1177/10454411910020030201
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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