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Bioindicators in the MIDUS National Study: Protocol, Measures, Sample, and Comparative Context
Open accessAbstract
Objectives: Midlife in the United States (MIDUS) is a national study of health and aging among individuals aged 25 to 74 at baseline (1995-1996). Longitudinal survey assessments (2004-2005), were followed by biological assessments on a subsample (aged 35-85).To facilitate public use, we describe the protocol, measures, and sample. Method: Respondents traveled to clinics for a 2-day data-collection protocol that included fasting blood specimens, 12-hr urine specimen, medical history, physical exam, bone densitometry, and a laboratory challenge (heart rate variability, blood pressure, respiration, salivary cortisol). Results: Response rates for the biological protocol ( N = 1,255) were 39.3% or 43.1% (adjusting for those who could not be located or contacted). Reasons for nonparticipation were travel, family obligations, and being too busy. Respondents were comparable to the recruitment pool on most demographic characteristics and health assessments. Discussion: Strengths of the protocol vis-à-vis similar studies include opportunities to link biological factors with diverse content from other MIDUS projects.
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“In contrast, in a U.S. sample of African-Americans (39), the depression facet of neuroticism was associated with higher CRP in participants with lower education, but lower CRP in those with greater education.”
From Socioeconomic Status Interacts with Conscientiousness and Neuroticism to Predict Circulating Concentrations of Inflammatory Markers (2017) · cites this paper as [39]
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“While the opposite pattern of interaction was observed in a Scottish cohort (38), a similar pattern involving a measure of trait depression emerged in a sample of African-Americans (39).”
From Socioeconomic Status Interacts with Conscientiousness and Neuroticism to Predict Circulating Concentrations of Inflammatory Markers (2017) · cites this paper as [39]
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Metadata
- Authors
- Dienberg Love, G., Seeman, T. E., Weinstein, M., & Ryff, C. D.
- Affiliations
- University of Wisconsin, Madison,
- University of California, Los Angeles (US)
- Georgetown University (US)
- University of Wisconsin–Madison (US)
- Venue
- Journal of Aging and Health
- Publisher
- SAGE Publications
- Published
- 2010-09-27
- Volume
- 22
- Issue
- 8
- Pages
- 1059-1080
- ISSN
- 0898-2643 (ISSN-L)
- 1552-6887
- PMC
- PMC2972372
- OpenAlex
- W1967392886
- Cited by
- 333
- References
- 18
- Citations by year
- 2026: 18 · 2025: 26 · 2024: 20 · 2023: 26 · 2022: 21 · 2021: 25 · 2020: 21 · 2019: 24 · 2018: 23 · 2017: 19 · 2016: 22 · 2015: 22 · 2014: 24 · 2013: 17 · 2012: 12
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Aging and Health (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Georgetown University
- National Institute on Aging (P01AG020166)
- National Center for Research Resources ((M01 RR00865), M01RR023942, UL1RR025011, M01RR000865)
- NIH Clinical Center
- Topics
- Social Sciences › Health › Health disparities and outcomes
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Social Sciences › Sociology and Political Science › Survey Methodology and Nonresponse
- Keywords
- bioindicators, MIDUS, midlife health, aging, biological evaluation, urine collection, bone densitometry, heart rate variability, blood pressure, salivary cortisol, respiration, response rate, non-participation, health and aging
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Blood Pressure, Clinical Protocols, Data Collection, Fasting, Female, Health Status, Health Surveys, Heart Rate, Humans, Longitudinal Studies, Male, Middle Aged, Patient Participation, Surveys and Questionnaires, Saliva, United States, Program Evaluation, Biomarkers, Bone Density
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