Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics
Open accessAbstract
In anticipation of the sequencing of the human genome and description of the human proteome, the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik) was initiated in 2002. AGES-Reykjavik was designed to examine risk factors, including genetic susceptibility and gene/environment interaction, in relation to disease and disability in old age. The study is multidisciplinary, providing detailed phenotypes related to the cardiovascular, neurocognitive (including sensory), and musculoskeletal systems, and to body composition and metabolic regulation. Relevant quantitative traits, subclinical indicators of disease, and medical diagnoses are identified by using biomarkers, imaging, and other physiologic indicators. The AGES-Reykjavik sample is drawn from an established population-based cohort, the Reykjavik Study. This cohort of men and women born between 1907 and 1935 has been followed in Iceland since 1967 by the Icelandic Heart Association. The AGES-Reykjavik cohort, with cardiovascular risk factor assessments earlier in life and detailed late-life phenotypes of quantitative traits, will create a comprehensive study of aging nested in a relatively genetically homogeneous older population. This approach should facilitate identification of genetic factors that contribute to healthy aging as well as the chronic conditions common in old age.
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Across studies, both muscle strength and muscle area are consistently associated with risk of mortality.
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- Authors
- Harris, T. B., Launer, L. J., Eiriksdottir, G., Kjartansson, O., Jonsson, P. V., Sigurdsson, G., Thorgeirsson, G., Aspelund, T., Garcia, M. E., Cotch, M. F., Hoffman, H. J., Gudnason, V., & for the Age, G. S.-R. S. I.
- Affiliations
- National Institutes of Health (US)
- University of Iceland (IS)
- Icelandic Heart Association (IS)
- National Institute on Deafness and Other Communication Disorders (US)
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-01-25
- Volume
- 165
- Issue
- 9
- Pages
- 1076-1087
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- PMC
- PMC2723948
- OpenAlex
- W2142560075
- Cited by
- 592
- References
- 47
- Citations by year
- 2026: 19 · 2025: 28 · 2024: 30 · 2023: 29 · 2022: 27 · 2021: 34 · 2020: 35 · 2019: 35 · 2018: 28 · 2017: 41 · 2016: 42 · 2015: 49 · 2014: 38 · 2013: 42 · 2012: 30
- FWCI
- 11.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- National Institutes of Health (n01ag12100-57-0-2, Z99 EY999999)
- National Institute on Aging (N01-AG012100, Z01AG007380)
- National Eye Institute (ZIAEY000401, Z01EY000401)
- National Institute on Deafness and Other Communication Disorders
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- AGES-Reykjavik Study, aging, healthy aging, gene-environment interaction, genetic susceptibility, older adults, cardiovascular risk factors, neurocognitive function, sensory function, musculoskeletal function, body composition, metabolic regulation, biomarkers, imaging, phenotyping, genetic homogeneity
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Body Composition, Cardiovascular Diseases, Chronic Disease, Dementia, Disease Susceptibility, Environment, Female, Genotype, Geriatrics, Health Status Indicators, Humans, Iceland, Male, Osteoporosis, Phenotype, Surveys and Questionnaires, Risk Factors, Genetic Variation, Risk Assessment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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