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Cited by 114Neurotransmitter Receptor Influence on BehaviorGenetic Associations and EpidemiologySchizophrenia research and treatment

Predicting Sensation Seeking From Dopamine Genes: A Candidate-System Approach

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Derringer, Jaime, Krueger, Robert F., Dick, Danielle M., Saccone, Scott, Grucza, Richard A., Agrawal, Arpana, Lin, Peng, Almasy, Laura +10 more·2010·Psychological Science
DOI 10.1177/0956797610380699PMC PMC3031097
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Abstract

Sensation seeking is a heritable personality trait that has been reliably linked to behavioral disorders. The dopamine system has been hypothesized to contribute to variations in sensation seeking between different individuals, and both experimental and observational studies in humans and nonhuman animals provide evidence for the involvement of the dopamine system in sensation-seeking behavior. In this study, we took a candidate-system approach to genetic association analysis of sensation-seeking behavior. We analyzed single-nucleotide polymorphisms (SNPs) from a number of dopaminergic genes. Using 273 SNPs from eight dopamine genes in a sample of 635 unrelated individuals, we examined the aggregate effect of SNPs that were significantly associated with sensation-seeking behavior. Multiple SNPs in four dopamine genes accounted for significant variance in sensation-seeking behavior between individuals. These results suggest that multiple SNPs, aggregated within genes that are relevant to a specific neurobiological system, form a genetic-risk score that may explain a significant proportion of observed variance in human traits such as sensation-seeking behavior.

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Authors
Derringer, J., Krueger, R. F., Dick, D. M., Saccone, S., Grucza, R. A., Agrawal, A., Lin, P., Almasy, L., Edenberg, H. J., Foroud, T., Nurnberger, J. I., Hesselbrock, V. M., Kramer, J. R., Kuperman, S., Porjesz, B., Schuckit, M. A., Bierut, L. J., & Gene Environment Association Studies (GENEVA) Consortium
Affiliations
  • University of Minnesota (US)
  • Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, Virginia
  • Washington University in St. Louis (US)
  • Washington University in St. Louis
  • Texas Biomedical Research Institute (US)
  • Indiana University Bloomington (US)
  • Indiana University
  • University of Connecticut (US)
  • University of Iowa (US)
  • University of Iowa
  • State University of New York Downstate Medical Center
  • University of California San Diego (US)
ORCID
Venue
Psychological Science
Publisher
SAGE Publications
Published
2010-08-23
Volume
21
Issue
9
Pages
1282-1290
ISSN
  • 0956-7976 (ISSN-L)
  • 1467-9280
DOI
10.1177/0956797610380699
PMC
PMC3031097
OpenAlex
W2137850664
Cited by
114
References
6
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 12 · 2019: 4 · 2018: 2 · 2017: 10 · 2016: 9 · 2015: 10 · 2014: 11 · 2013: 8 · 2012: 14
FWCI
5.18
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Psychological Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • SUNY Digital Repository Support (State University of New York System) (submittedVersion, cc-by-nc-nd)
Funders
  • National Institutes of Health (n01hg72096-7-0-1)
  • National Institute on Alcohol Abuse and Alcoholism (K02AA018755, U10AA008401)
  • National Institute on Drug Abuse (K01DA024722, DA024722, R01DA019963, R01DA013423)
  • National Human Genome Research Institute (U01HG004422, U01HG004446, U01HG004438, HHSN268200782096C, N01 HG072096)
  • National Cancer Institute (P01CA089392)
  • National Institute of Dental and Craniofacial Research (U01DE017018)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
sensation seeking, dopamine genes, dopaminergic system, single nucleotide polymorphisms, genetic association, polygenic risk score, heritability, personality traits
MeSH terms
Adult, Aged, Dopamine, Exploratory Behavior, Female, Genotype, Humans, Male, Middle Aged, Psychological Tests, Sensation, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Young Adult

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