Work disability in systemic lupus erythematosus is prevalent and associated with socio-demographic and disease related factors
Abstract
Our objectives were to examine the prevalence of work disability (WD) and factors associated with job loss in systemic lupus erythematosus (SLE) in a large, multi-centered Canadian sample to determine the current prevalence of WD and identify the contribution of disease activity, damage, and co-morbidities with respect to WD in this cohort. Cross-sectional data on WD status from the 1000 Canadian Faces of Lupus database (a multi-center multi-ethnic cohort of SLE patients) along with clinical measures (number of ACR criteria ever, SLICC Damage Index, SLAM, SLEDAI, SF-36 and Charlson Co-morbidity Index scores), demographic features (age, sex, high school education, household income, marital status, disease duration, employment status) and co-morbidities (including self-reported fibromyalgia, arthralgias, depression and fatigue) were used in bivariate and logistic regression analyses. The 1137 SLE patients had a mean age of 50 years (SE 0.75) and mean disease duration was 18 years (SE 0.70); 19.09% were work disabled and 49.78% were employed. Those with WD were more likely than non-WD SLE patients to have: a higher number of ACR criteria for SLE; not completed high school; older age; single marital status; a lower household income; longer disease duration; higher SLICC Damage Index and SLAM scores; lower SF-36 PCS and SF-36 MCS scores; less vigorous activity per week; and fibromyalgia, arthralgias, fatigue and depression (p < 0.05). This contemporary rate of WD is lower than many past reports. Socio-demographic factors, co-morbidities (fibromyalgia and fatigue) and disease related factors were strongly associated with WD. We cannot determine cause and effect as the study was cross-sectional. Lupus (2009) 18, 1281—1288.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Impaired health status assessed by SF-36 has earlier been associated with work disability in rheumatoid arthritis, systemic lupus erythematosus and musculoskeletal pain.
“Impaired health status assessed by SF-36 has earlier been associated with work disability in rheumatoid arthritis (RA) [35], systemic lupus erythematosus (SLE) [40] and musculoskeletal pain [41].”
From Which aspects of health differ between working and nonworking women with fibromyalgia? A cross-sectional study of work status and health (2012) · cites this paper as [40]
Cites
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742 · see citing works
The 1982 revised criteria for the classification of systemic lupus erythematosus
Tan, E. M., Cohen, A. S., Fries, J. F., Masi, A. T., Mcshane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., & Winchester, R. J. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780251101 · Cited by 14,519 · see citing works
Overview of the SF-36 Health Survey and the International Quality of Life Assessment (IQOLA) Project
Ware, J. E., & Gandek, B. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00081-x · Cited by 2,606 · see citing works
Liang, M. H., Socher, S. A., Larson, M. G., & Schur, P. H. (1989) · Arthritis & Rheumatism · doi:10.1002/anr.1780320909 · Cited by 787 · see citing works
The prevalence and clinical impact of fibromyalgia in systemic lupus erythematosus
Middleton, G. D., Mcfarlin, J. E., & Lipsky, P. E. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780370812 · Cited by 208 · see citing works
Mau, W., Listing, J., Huscher, D., et al. (2005) · PubMed · Cited by 178 · see citing works
Employment and work disability in systemic lupus erythematosus: a systematic review
Baker, K., & Pope, J. E. (2008) · Lara D. Veeken · doi:10.1093/rheumatology/ken477 · Cited by 147 · see citing works
Self-citationWork dynamics among persons with systemic lupus erythematosus
Yelin, E. H., Trupin, L. S., Katz, P., et al. (2007) · Arthritis Care & Research · doi:10.1002/art.22481 · Cited by 131 · see citing works
Yazdany, J., Yelin, E. H., Panopalis, P., Trupin, L. S., Julian, L. J., & Katz, P. (2007) · Arthritis Care & Research · doi:10.1002/art.23238 · Cited by 118 · see citing works
Jönsen, A. (2002) · British journal of rheumatology · doi:10.1093/rheumatology/41.11.1308 · Cited by 116 · see citing works
Total costs and predictors of costs in patients with systemic lupus erythematosus
Sutcliffe, N. (2001) · British journal of rheumatology · doi:10.1093/rheumatology/40.1.37 · Cited by 112 · see citing works
The SLICC/ACR damage index: progress report and experience in the field
Gladman, D. D., & Urowitz, M. B. (1999) · Lupus · doi:10.1191/096120399680411335 · Cited by 103 · see citing works
Clarke, A. E., Esdaile, J., Bloch, D. A., Lacaille, D., Danoff, D., & Fries, J. (1993) · Arthritis & Rheumatism · doi:10.1002/art.1780361109 · Cited by 96 · see citing works
Bertoli, A. M., Fernández, M., Alarcón, G. S., Vilá, L. M., & Reveille, J. D. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.055343 · Cited by 84 · see citing works
Rheumatological manifestations, organ damage and autoimmunity in hereditary C2 deficiency
Jönsson, G., Sjöholm, A. G., Truedsson, L., Bengtsson, A. A., Braconier, J. H., & Sturfelt, G. K. (2007) · Lara D. Veeken · doi:10.1093/rheumatology/kem023 · Cited by 84 · see citing works
Partridge, A. J., Fossel, A. H., Karlson, E. W., et al. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780401214 · Cited by 84 · see citing works
Boomsma, M. M., Bijl, M., Stegeman, C. A., Kallenberg, C. G. M., Hoffman, G. S., & Tervaert, J. W. C. (2002) · Arthritis Care & Research · doi:10.1002/art.10341 · Cited by 82 · see citing works
The systemic lupus erythematosus Tri‐Nation study: Cumulative indirect costs
Panopalis, P., Petri, M., Manzi, S., Isenberg, D. A., Gordon, C., Senécal, J., Penrod, J. R., Joseph, L., Pierre, Y. S., Pineau, C. A., et al. (2007) · Arthritis Care & Research · doi:10.1002/art.22470 · Cited by 69 · see citing works
Self-citationStamm, T., Bauernfeind, B., Coenen, M., et al. (2007) · Arthritis Care & Research · doi:10.1002/art.23013 · Cited by 65 · see citing works
Clarke, A., Penrod, J. R., Pierre, Y. S., et al. (2000) · PubMed · Cited by 54 · see citing works
Utset, T. O., Fink, J. W., & Doninger, N. A. (2006) · PubMed · Cited by 53 · see citing works
Arthritis and employment research: where are we? Where do we need to go?
Lacaille, D. V. (2005) · PubMed · Cited by 45 · see citing works
Validity of the Dictionary of Occupational Titles Residual Functional Capacity Battery
Fishbain, D. A., Cutler, R. B., Rosomoff, H. L., et al. (1999) · Clinical Journal of Pain · doi:10.1097/00002508-199906000-00006 · Cited by 43 · see citing works
Huang, H., Chou, C., Lin, K., et al. (2007) · Journal of Nursing Research · doi:10.1097/01.jnr.0000387596.32532.54 · Cited by 38 · see citing works
Lacaille, D. V., Clarke, A., Bloch, D. A., et al. (1994) · PubMed · Cited by 26 · see citing works
Nived, O., Andersson, M., Lindgren, M., et al. (2007) · Lupus · doi:10.1177/0961203307080635 · Cited by 23 · see citing works
Musculoskeletal Features in Systemic Lupus Erythematosus and Their Relationship with Disability
Murphy, N. G., Koolvisoot, A., Schumacher, R. H., et al. (1998) · JCR Journal of Clinical Rheumatology · doi:10.1097/00124743-199810000-00003 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Palstam, A., Bjersing, J. L., & Mannerkorpi, K. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-1076 · Cited by 31 · see citing works
“Impaired health status assessed by SF-36 has earlier been associated with work disability in rheumatoid arthritis (RA) [35], systemic lupus erythematosus (SLE) [40] and musculoskeletal pain [41].”
Background
- Authors
- Baker, K., Pope, J., Fortin, P., Silverman, E., Peschken, C., & 1000 Faces of Lupus Investigators and CaNIOS (Canadian Network for Improved Outcomes in SLE)
- Affiliations
- Queen's University (CA)
- Western University (CA)
- University Health Network (CA)
- University of Toronto (CA)
- University of Manitoba (CA)
- Venue
- Lupus
- Publisher
- SAGE Publications
- Published
- 2009-10-23
- Volume
- 18
- Issue
- 14
- Pages
- 1281-1288
- ISSN
- 0961-2033 (ISSN-L)
- 1477-0962
- OpenAlex
- W2058646103
- Cited by
- 78
- References
- 27
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 5 · 2019: 1 · 2018: 9 · 2017: 7 · 2016: 2 · 2015: 10 · 2014: 10 · 2013: 5 · 2012: 5
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lupus (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Lupus Canada
- Arthritis Society
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Social Sciences › Demography › Retirement, Disability, and Employment
- Social Sciences › Safety Research › Disability Education and Employment
- Keywords
- systemic lupus erythematosus, work disability, job loss, prevalence, sociodemographic factors, disease activity, organ damage, comorbidities, fibromyalgia, fatigue, depression, joint pain, household income, employment status
- MeSH terms
- Adult, Canada, Cross-Sectional Studies, Depression, Employment, Fatigue, Female, Fibromyalgia, Humans, Lupus Erythematosus, Systemic, Male, Middle Aged, Risk Factors, Socioeconomic Factors, Comorbidity, Prevalence, Logistic Models, Sick Leave, Arthralgia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
