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Group-based multi-trajectory modeling

Nagin, Daniel S, Jones, Bobby L, Passos, Valéria Lima, Tremblay, Richard E·2018·Statistical Methods in Medical Research

Abstract

Identifying and monitoring multiple disease biomarkers and other clinically important factors affecting the course of a disease, behavior or health status is of great clinical relevance. Yet conventional statistical practice generally falls far short of taking full advantage of the information available in multivariate longitudinal data for tracking the course of the outcome of interest. We demonstrate a method called multi-trajectory modeling that is designed to overcome this limitation. The method is a generalization of group-based trajectory modeling. Group-based trajectory modeling is designed to identify clusters of individuals who are following similar trajectories of a single indicator of interest such as post-operative fever or body mass index. Multi-trajectory modeling identifies latent clusters of individuals following similar trajectories across multiple indicators of an outcome of interest (e.g., the health status of chronic kidney disease patients as measured by their eGFR, hemoglobin, blood CO 2 levels). Multi-trajectory modeling is an application of finite mixture modeling. We lay out the underlying likelihood function of the multi-trajectory model and demonstrate its use with two examples.

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Research works printed but not linked: 3

  1. 10.1037/1082-989X.6.1.18 · DOI · Paper page
  2. Elmer J, Gianakas JJ, Rittenberger JC, et al. Group-based trajectory modeling of suppression ratio after cardiac arrest. Neurocrit Care 2016; 25 : 415–423. · doi:10.1007/s12028-016-0263-9
  3. Shah N, 2015, AMIA-DMMI

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Metadata

Authors
Nagin, D. S., Jones, B. L., Passos, V. L., & Tremblay, R. E.
Venue
Statistical Methods in Medical Research
Published
2016-10-17
Volume
27
Issue
7
Pages
2015-2023
ISSN
  • 0962-2802 (ISSN-L)
  • 1477-0334
OpenAlex
W2537229494
Cited by
932
References
13
FWCI
17.70
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)

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CoChat. (2026). Citation check: Group-based multi-trajectory modeling. https://app.cochat.ai/papers/10.1177/0962280216673085
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Nagin, D. S., Jones, B. L., Passos, V. L., & Tremblay, R. E. (2018). Group-based multi-trajectory modeling. Statistical Methods in Medical Research. https://doi.org/10.1177/0962280216673085

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