Cited by 64Lipoproteins and Cardiovascular HealthCardiovascular Health and Disease PreventionNitric Oxide and Endothelin Effects

Influence of short-term rosuvastatin therapy on endothelial progenitor cells and endothelial function

Pirro, Matteo, Schillaci, Giuseppe, Romagno, Paolo F., Mannarino, Massimo R., Bagaglia, Francesco, Razzi, Rolando, Pasqualini, Leonella, Vaudo, Gaetano +1 more·2009·Journal of Cardiovascular Pharmacology and Therapeutics

Abstract

Endothelial progenitor cells maintain endothelium integrity by replacing injured endothelial cells. Cholesterol-lowering promotes either endothelial progenitor cells mobilization or improves endothelial function. It is unknown whether improving endothelial function with statin is associated with a parallel increased endothelial progenitor cells availability. Thirty-two hypercholesterolemic patients were assigned to 4-week rosuvastatin (10 mg daily) and 16 hypercholesterolemic served as controls. Circulating endothelial progenitor cells, brachial artery flow-mediated vasodilatation, an index of endothelial function, and the lipid profile were measured before and after the 4-week statin therapy. At baseline, we found a correlation between circulating endothelial progenitor cells and flow-mediated vasodilatation (r = .31, P = .029). At the end of the 4-week intervention with rosuvastatin there was a 37% reduction in low-density lipoprotein cholesterol (P < .001) and a significant 72% increase in the number of endothelial progenitor cells and flow-mediated vasodilatation (4.7 + 0.7% to 8.8 + 0.4%, P < .001). Endothelial progenitor cells and flow-mediated vasodilatation were unchanged at the end of the study in patients not taking statin. A correlation emerged between endothelial progenitor cells and flow-mediated vasodilatation variations (r = .52, P < .001), this correlation being still significant after controlling for blood cholesterol reduction. In conclusion, short-term rosuvastatin therapy contributes in hyperchoelsterolemic patients to improving endothelial function by lowering cholesterol and increasing the number of circulating endothelial progenitor cells; the latter effect appears to be partly independent from reduction in plasma cholesterol.

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Crossref · 10.1177/1074248408331021

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28 of 28 references verified0 citation errors · 0 not checkable

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  • Cholesterol-lowering attenuation of inflammation may positively influence vascular injury and cardiovascular prognosis.

    “Hence, it is believed that attenuation of inflammation by cholesterol lowering may have a positive influence on vascular injury (151) and CV prognosis (152).”

    From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [151]

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Authors
Pirro, M., Schillaci, G., Romagno, P. F., Mannarino, M. R., Bagaglia, F., Razzi, R., Pasqualini, L., Vaudo, G., & Mannarino, E.
Affiliations
University of Perugia (IT)
Corresponding author
Pirro, Matteo
Venue
Journal of Cardiovascular Pharmacology and Therapeutics
Published
2009-03
Volume
14
Issue
1
Pages
14-21
ISSN
  • 1074-2484 (ISSN-L)
  • 1940-4034
OpenAlex
W2113841285
Cited by
64
References
27
Citations by year
2026: 2 · 2023: 6 · 2022: 5 · 2021: 6 · 2019: 1 · 2018: 8 · 2017: 8 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 5
FWCI
6.05
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cardiovascular Pharmacology and Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fondazione Cassa di Risparmio di Perugia
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
rosuvastatin, endothelial progenitor cells, endothelial function, flow-mediated dilation, hypercholesterolemia, statins, LDL cholesterol lowering, brachial artery, lipid profile
MeSH terms
Rosuvastatin Calcium, Cholesterol, Drug Administration Schedule, Endothelium, Vascular, Female, Fluorobenzenes, Humans, Hypercholesterolemia, Male, Middle Aged, Prospective Studies, Pyrimidines, Stem Cells, Sulfonamides, Vasodilation, Treatment Outcome, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Endothelial Cells

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