Relation of Plasma Fibrinogen Level With the Presence, Severity, and Complexity of Coronary Artery Disease
Open accessAbstract
Background: Relation of plasma fibrinogen levels with extent, severity, and complexity of coronary artery disease (CAD) in patients with stable angina pectoris (SAP) has not been adequately investigated. The aim of this study was to evaluate whether plasma fibrinogen level is associated with coronary complexity, severity, and extent assessed by SYNTAX (Synergy between percutaneous coronary intervention with TAXUS and Cardiac Surgery) score (SS). Methods: We enrolled 134 consecutive patients with SAP who underwent coronary angiography. Baseline serum fibrinogen levels were measured, and SS was calculated from the study population. The patients were classified into 3 groups by tertiles of SS (SS, control group = 0; intermediate group < 22; and high group ≥ 22). Results: Plasma fibrinogen levels demonstrated a stepwise increase from control group to high SS group. There was a strong correlation between fibrinogen and the SS ( r = .535, P < .001). Area under the receivers operating characteristic curve of fibrinogen was 0.72 (95% confidence interval [CI] 0.61-0.82; < .001) for predicting a high SS. Fibrinogen value higher than 411 mg/dL has a sensitivity of 75% and a specificity of 64% in prediction of high SS. In multivariate analyses, plasma fibrinogen was observed to be an independent predictor for high SS in patients with stable CAD (odds ratio [OR] 1.01; 95% CI, 1.01-1.02; P < .001). Conclusion: Plasma fibrinogen is a readily measurable systemic inflammatory marker and is independently associated coronary severity and complexity in patients with CAD.
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High levels of fibrinogen and plasminogen activator inhibitor-1 (PAI-1) are markers for ASCVD.
“High levels of fibrinogen and plasminogen activator inhibitor-1 (PAI-1) are markers for ASCVD. (Evidence level: E-1a)”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [298]
Fibrinogen is an independent risk factor for cardiovascular disease.
“Fibrinogen is an independent risk factor for cardiovascular disease297–299).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [298]
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Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
- Authors
- Tabakcı, M. M., Gerin, F., Sunbul, M., Toprak, C., Durmuş, H. İ., Demir, S., Arslantaş, U., Cerşit, S., Batgerel, U., & Kargın, R.
- Affiliations
- Cardiology Department, Kartal Koşuyolu Cardiovascular Research and Training Hospital, Istanbul, Turkey
- Public Health Core Laboratory, Istanbul, Turkey
- Department of Cardiology, Medical Faculty, Marmara University, Istanbul, Turkey
- Tavşanlı State Hospital, Kutahya, Turkey
- Kartal Koşuyolu High Specialization Training and Research Hospital (TR)
- Venue
- Clinical and Applied Thrombosis/Hemostasis
- Publisher
- SAGE Publications
- Published
- 2016-02-09
- Volume
- 23
- Issue
- 6
- Pages
- 638-644
- ISSN
- 1076-0296 (ISSN-L)
- 1938-2723
- OpenAlex
- W2462635016
- Cited by
- 41
- References
- 34
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 3 · 2023: 9 · 2022: 1 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 3
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical and Applied Thrombosis/Hemostasis (publishedVersion)
- PubMed (publishedVersion)
- Dspace Repository (Marmara Üniversitesi) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- fibrinogen, coronary artery disease, stable angina, SYNTAX score, coronary lesion complexity, coronary lesion severity, systemic inflammation, inflammatory markers, coronary angiography
- MeSH terms
- Aged, Coronary Artery Disease, Cross-Sectional Studies, Female, Fibrinogen, Humans, Male, Middle Aged, Sensitivity and Specificity, Severity of Illness Index, Coronary Angiography, Angina, Stable
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