The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen
Abstract
ZAP-70 is a critical molecule in the transduction of T cell antigen receptor signaling and the activation of T cells. Upon activation of the T cell antigen receptor, ZAP-70 is recruited to the intracellular ζ-chains of the T cell receptor, where ZAP-70 is activated and colocalized with its substrates. Inhibitors of ZAP-70 could potentially function as treatments for autoimmune diseases or organ transplantation. In this work, we present the design, optimization, and implementation of a screen for inhibitors that would disrupt the interaction between ZAP-70 and the T cell antigen receptor. The screen is based on a fluorescence polarization assay for peptide binding to ZAP-70.
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“Several studies have identified potential ZAP−70 inhibitors that can modulate the interaction with TCR [114].”
From The Role of RhoH in TCR Signalling and Its Involvement in Diseases (2021) · cites this paper as [114]
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Cites
Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases
Iwashima, M., Irving, B. A., van Oers, N. S. C., Chan, A. C., & Weiss, A. (1994) · Science · doi:10.1126/science.7509083 · Cited by 714
Self-citationZAP-70: an essential kinase in T-cell signaling
Wang, H., Kadlecek, T. A., Au-Yeung, B. B., Goodfellow, H. E. S., Hsu, L. Y., Freedman, T. S., & Weiss, A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002279 · Cited by 395
Self-citationMolecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor
Hatada, M. H., Lu, X., Laird, E. R., Green, J., Morgenstern, J. P., Lou, M., Marr, C. S., Phillips, T. B., Ram, M. K., Theriault, K., et al. (1995) · Nature · doi:10.1038/377032a0 · Cited by 351
Irving, B. A., Chan, A. C., & Weiss, A. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.4.1093 · Cited by 304
Self-citationStructural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70
Deindl, S., Kadlecek, T. A., Brdicka, T., Cao, X., Weiss, A., & Kuriyan, J. (2007) · Cell · doi:10.1016/j.cell.2007.03.039 · Cited by 234
Self-citationBu, J.-Y., Shaw, A. S., & Chan, A. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.5106 · Cited by 158
Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker
Yan, Q., Barros, T. F., Visperas, P. R., Deindl, S., Kadlecek, T. A., Weiss, A., & Kuriyan, J. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01637-12 · Cited by 124
Self-citationTurek-Etienne, T. C., Small, E. C., Soh, S. C., Xin, T. A., Gaitonde, P. V., Barrabee, E. B., Hart, R. F., & Bryant, R. W. (2003) · SLAS DISCOVERY · doi:10.1177/1087057103252304 · Cited by 102
Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.
Qian, D., Mollenauer, M. N., & Weiss, A. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.2.611 · Cited by 99
Self-citationDiscovery of Potent and Selective SH2 Inhibitors of the Tyrosine Kinase ZAP-70
Vu, C. B., Corpuz, E. G., Merry, T. J., Pradeepan, S. G., Bartlett, C., Bohacek, R. S., Botfield, M. C., Eyermann, C. J., Lynch, B. A., MacNeil, I. A., et al. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm990229t · Cited by 90
Cited by
The Role of RhoH in TCR Signalling and Its Involvement in Diseases
Ahmad Mokhtar, A. M., Hashim, I. F., Mohd Zaini Makhtar, M., Salikin, N. H., & Amin-Nordin, S. (2021) · Cells · doi:10.3390/cells10040950 · Cited by 25
Metadata
- Authors
- Visperas, P. R., Wilson, C. G., Winger, J. A., Yan, Q., Lin, K., Arkin, M. R., Weiss, A., & Kuriyan, J.
- Venue
- SLAS Discovery
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 22
- Issue
- 3
- Pages
- 324-331
- ISSN
- 2472-5552
- PMC
- PMC5491343
- Cited by
- 19
- References
- 15
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 1855 d)
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