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Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases
Abstract
The T cell antigen receptor (TCR) initiates signals by interacting with cytoplasmic protein tyrosine kinases (PTKs) through a 17-residue sequence motif [called the antigen recognition activation motif (ARAM)] that is contained in the TCRζ and CD3 chains. TCR stimulation induces the tyrosine phosphorylation of several cellular substrates, including the ARAMs. Lck kinase activity is required for phosphorylation of two conserved tyrosine residues in an ARAM. This phosphorylation leads to the recruitment of a second cytoplasmic PTK, ZAP-70, through both of the ZAP-70 Src homology 2 domains and its phosphorylation. Thus, TCR signal transduction is initiated by the sequential interaction of two PTKs with TCR ARAMs.
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Citations
Cited by
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Pawson, T. (1995) · Nature · doi:10.1038/373573a0 · Cited by 2,420
Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144
Dimerization of cell surface receptors in signal transduction
Heldin, C.-H. (1995) · Cell · doi:10.1016/0092-8674(95)90404-2 · Cited by 1,634
Rassenti, L. Z., Huynh, L., Toy, T. L., Chen, L., Keating, M. J., Gribben, J. G., Neuberg, D. S., Flinn, I. W., Rai, K. R., Byrd, J. C., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040857 · Cited by 745
Self-citationRegulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4
Marengère, L. E. M., Waterhouse, P., Duncan, G. S., Mittrücker, H.-W., Feng, G.-S., & Mak, T. W. (1996) · Science · doi:10.1126/science.272.5265.1170 · Cited by 551
Metadata
- Authors
- Iwashima, M., Irving, B. A., van Oers, N. S. C., Chan, A. C., & Weiss, A.
- Venue
- Science
- Published
- 1994-02-25
- Volume
- 263
- Issue
- 5150
- Pages
- 1136-1139
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1983960385
- Cited by
- 714
- References
- 0
- FWCI
- 32.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Iwashima, M., Irving, B. A., van Oers, N. S. C., Chan, A. C., & Weiss, A. (1994). Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases. Science. https://doi.org/10.1126/science.7509083
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