Developmental Toxicity of Homobrassinolide in Wistar Rats
Open accessAbstract
Brassinosteroids (BRs) are close analogues of animal cholesterol. Brassinosteroids have shown their great value as yield promoters of a variety of plants. In view of its steroidal moiety and recent use in agriculture in many countries, the teratogenic potential of homobrassinolide (HBR) was evaluated in Wistar rats. Homobrassinolide was administered by oral gavage at doses 0, 100, and 1000 mg/kg body weight in water during gestation days (GD) 6 to 15 in groups of 20 mated females. Maternal and embryo-fetal toxicity was analyzed by studying the effects such as clinical signs, mortality/morbidity, abortions, body weight, feed consumption, and pregnancy data, gravid uterine weights, implantation losses, litter size, external, visceral, and skeletal malformations. No treatment-related effect was observed on any of the maternal/fetal end points in any dose group. From the results, it can be concluded that HBR is nonteratogenic at doses as high as up to 1000 mg/kg body weight in Wistar rats.
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HB was safe in rats when tested at doses up to 1000 mg/kg.
“HB was safe in rats when tested at doses up to 1000 mg/kg (58).”
From Anabolic effect of plant brassinosteroid (2011) · cites this paper as [58]
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Anabolic effect of plant brassinosteroid
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- Authors
- Murkunde, Y. V., & Balakrishna Murthy, P.
- Affiliations
- International Institute of Biotechnology and Toxicology (IN)
- International Institute of Biotechnology and Toxicology (IIBAT), Padappai, Tamil Nadu, India
- Venue
- International Journal of Toxicology
- Publisher
- SAGE Publications
- Published
- 2010-09
- Volume
- 29
- Issue
- 5
- Pages
- 517-522
- ISSN
- 1091-5818 (ISSN-L)
- 1092-874X
- OpenAlex
- W2080912204
- Cited by
- 11
- References
- 42
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- homobrassinolide, brassinosteroids, developmental toxicity, teratogenicity, prenatal exposure, gestation, embryo-fetal toxicity, maternal toxicity, skeletal deformities, Wistar rats
- MeSH terms
- Animals, Cholestanones, Dose-Response Relationship, Drug, Female, Pregnancy, Random Allocation, Teratogens, Agrochemicals, Rats, Wistar, Toxicity Tests, Maternal Exposure, Fetal Development, Rats
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