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Cited by 16Barrier Structure and Function StudiesIon Channels and ReceptorsHeavy Metal Exposure and Toxicity

The DOI matches its Crossref record.

Malathion/Oxon and Lead Acetate Increase Gene Expression and Protein Levels of Transient Receptor Potential Canonical Channel Subunits TRPC1 and TRPC4 in Rat Endothelial Cells of the Blood–Brain Barrier

Balbuena, Pergentino, Li, Wen, Rzigalinski, Beverly A., Ehrich, Marion·2012·International Journal of Toxicology
DOI 10.1177/1091581812442688
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Abstract

This study examined the effects of malathion and lead on transient receptor potential canonical channel TRPC1/TRPC4 channels in rat brain endothelial cells as a mechanism to explain previously noted blood-brain barrier (BBB) permeability induced by these compounds. Lead, malathion, malaoxon and combinations of these were assessed for protein levels and gene expression of TRPC1/C4 at 2, 4, 8, 16, and 24 hours after exposure. Changes in intracellular free calcium dynamics were also assessed. Compounds increased TRPC1 and TRPC4 protein levels as well as gene expression within 4 hours after exposure. Basal levels of intracellular free calcium were also elevated. Increases in gene and protein expression may be associated with an increase in the numbers of TRP channels, and the increases in intracellular calcium may be associated with activation of such channels. Therefore, upregulation and activation of the TRPC1/TRPC4 may be a mechanism by which these neurotoxicants affect BBB permeability.

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Metadata

Authors
Balbuena, P., Li, W., Rzigalinski, B. A., & Ehrich, M.
Affiliations
  • Virginia–Maryland College of Veterinary Medicine (US)
  • Edward Via College of Osteopathic Medicine (US)
Corresponding author
Ehrich, Marion
ORCID
Venue
International Journal of Toxicology
Publisher
SAGE Publications
Published
2012-06
Volume
31
Issue
3
Pages
238-249
ISSN
  • 1091-5818 (ISSN-L)
  • 1092-874X
DOI
10.1177/1091581812442688
OpenAlex
W2118834167
Cited by
16
References
0
Citations by year
2024: 1 · 2023: 3 · 2021: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2015: 1 · 2014: 1 · 2013: 1
FWCI
0.48
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • International Journal of Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
malathion, malaoxon, lead acetate, lead, TRPC1, TRPC4, TRP channels, blood-brain barrier permeability, brain endothelial cells, gene expression, protein abundance, intracellular calcium, neurotoxicity, pesticide toxicity
MeSH terms
Animals, Blood-Brain Barrier, Calcium, Cell Line, Gene Expression Regulation, Insecticides, Malathion, Organometallic Compounds, Endothelial Cells, TRPC Cation Channels, Rats

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