The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
Antepartum Bed Rest for Pregnancy Complications: Efficacy and Safety for Preventing Preterm Birth
Abstract
Preterm birth is the major maternal-child health issue across developed nations and the leading cause of perinatal mortality and morbidity. Of all deaths of infants <1 year of age in the United States in 2005, 68.6% occurred in infants born prior to term. Although the preterm birth rate in European countries is 5-7%, the U.S. preterm birth rate is 12.7%, representing an increase of 9% since 2000. Antepartum bed rest/activity restriction (ABR/AR) has been a mainstay of treatment to prevent preterm birth for the past 30 years prescribed for nearly 1 million women in the United States annually, despite a lack of evidence for its effectiveness. In fact, there is increasing evidence that ABR causes several adverse physiologic and psychological side effects among women and their infants. Unfortunately, these findings have had little impact on clinical practice. This integrative review of literature provides a comprehensive analysis of the evidence for the practice of prescribing ABR and its physiologic, behavioral, and experiential side effects. It also presents a model to guide continuing research about the effects of maternal bed rest as well as evidence supporting the use of home care with bed rest, a different, safe, and feasible model of prenatal care for treating women with pregnancy complications used particularly in other countries. Finally, suggestions to improve the health of high-risk pregnant and postpartum women and their infants are provided.
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In the citing paper
“There is no evidence to support the use of activity restriction during pregnancy at home or in hospital, and practitioners should not assume efficacy for bed-rest treatment until evidence is produced [9,10,18,19].”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“The second assumption behind antepartum bed-rest treatment, that it is safe for mothers and their fetuses/infants, has no data providing evidence to support it [10].”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“Studies of women treated with pregnancy bed-rest identify numerous side effects, including muscle atrophy, bone loss, weight loss, decreased infant birthweight in singleton gestations and gestational age at birth, and psychosocial problems.”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“Studies of women treated with pregnancy bed-rest identify numerous side effects, including muscle atrophy, bone loss, weight loss, decreased infant birthweight in singleton gestations and gestational age at birth, and psychosocial problems.”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“Studies of women treated with pregnancy bed-rest identify numerous side effects, including muscle atrophy, bone loss, weight loss, decreased infant birthweight in singleton gestations and gestational age at birth, and psychosocial problems.”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“Studies of women treated with pregnancy bed-rest identify numerous side effects, including muscle atrophy, bone loss, weight loss, decreased infant birthweight in singleton gestations and gestational age at birth, and psychosocial problems.”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“Studies of women treated with pregnancy bed-rest identify numerous side effects, including muscle atrophy, bone loss, weight loss, decreased infant birthweight in singleton gestations and gestational age at birth, and psychosocial problems.”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“Studies of women treated with pregnancy bed-rest identify numerous side effects, including muscle atrophy, bone loss, weight loss, decreased infant birthweight in singleton gestations and gestational age at birth, and psychosocial problems.”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“Thus, the variables of bed-rest treatment and high-risk pregnancy are confounded [10].”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“Still, other practitioners believe that bed rest is of little benefit but report continued use [1,4,10].”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“Research documents that most obstetric healthcare providers are unaware of the adverse effects of bed rest or they believe that effects are of minor consequence [1,3,4,10,18].”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“Prescription of bed rest may continue because fellow colleagues also prescribe it [4,10].”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“Others state that they use bed rest because there are limited effective interventions to prevent preterm birth, and that abstaining from using interventions in high-risk pregnancy is difficult since neonatal outcomes are often serious [4,10].”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“Therefore, continued use appears to be due to a lack of knowledge or attention to research regarding effectiveness and the adverse side effects, or a discounting of the evidence [4,10].”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“Prescription of bed rest appears to be based upon the belief that rest does little harm and that maternal activity is related to physical forces that stimulate uterine contractions, cervical effacement and dilation [1,4,10].”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“Despite these new data, prescription of bed rest in the USA, Canada and other countries continues [1–4,10].”
From Lack of evidence for prescription of antepartum bed rest (2011) · cites this paper as [10]
In the citing paper
“Health concerns, loss of control, uncertainty, isolation, separation from home, bed rest, physical discomfort, and obstetric treatments that are often physically and psychologically invasive constitute important stressors (11, 12).”
From Acceptance, experiences, and needs of hospitalized pregnant women toward an electronic mindfulness-based intervention: A pilot mixed-methods study (2022) · cites this paper as [12]
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“[25] Maloni JA: Antepartum bed rest for pregnancy complications: efficacy and safety for preventing preterm birth.”
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Metadata
- Authors
- Maloni, J. A.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Maloni, Judith A.
- Venue
- Biological Research For Nursing
- Publisher
- SAGE Publications
- Published
- 2010-08-26
- Volume
- 12
- Issue
- 2
- Pages
- 106-124
- ISSN
- 1099-8004 (ISSN-L)
- 1552-4175
- OpenAlex
- W2032618589
- Cited by
- 135
- References
- 133
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 60 · 2016: 9 · 2015: 6 · 2014: 5 · 2013: 13 · 2012: 6
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Research For Nursing (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (R01 NRO3323)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- activity limitation, preterm birth prevention, pregnancy complications, psychological impact, home care, high-risk pregnancy, postpartum women, perinatal mortality
- MeSH terms
- Bed Rest, Female, Humans, Obstetric Labor, Premature, Pregnancy, Pregnancy Complications
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