Primary Tuberculosis of the Pharynx in an HIV Context: A Case Report
Open accessAbstract
Pharyngeal tuberculosis without pulmonary involvement is very rare and may be confused with malignant lesions. We present a 45-year-old female patient with a history of HIV presenting with a history of cough, sore throat, and oral ulcers with chronic use of antibiotics. The evolution would indicate a probable malignant tumor, but the biopsy was consistent with Pharyngeal TB. The patient initiated anti-tuberculosis therapy and demonstrated improved conditions and remission of ulcers. In the context of HIV, this treatment could be a major contributor to the underdiagnosis of the disease and may lead to alternative diagnoses. Therefore, it is vital to consider this condition in patients who do not respond to antibiotics.
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Head and neck EPTB is difficult to diagnose because pulmonary involvement is mostly absent and it clinically resembles neoplastic or chronic inflammatory conditions.
“due to mostly absent pulmonary involvement and high clinical resemblance to neoplastic or chronic inflammatory conditions”
From Head and Neck Tuberculosis: A Rare Diagnosis and the Role of Surgical Biopsy and Histopathological Evaluation in Extrapulmonary Disease (2025) · cites this paper as [16]
The Discussion says pharyngeal TB is typically linked with lung foci and that isolated pharyngeal involvement is exceedingly uncommon—the opposite of the claim that pulmonary involvement is mostly absent. The Introduction and Case Report support the separate point that it can resemble a neoplastic lesion, but this case report does not establish that pattern for head and neck EPTB generally. (LLM, conf=0.86)
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Sorted by citations
Mogoantă, C. A., Osman, A., Georgescu, A.-M., Mitroi, A. M., Busuioc, C. I., Tănase, I., Cioboată, R., Liliac, I. M., Cimpeanu, O. L., & Ciolofan, M. S. (2025) · Pathogens · doi:10.3390/pathogens14050479 · Cited by 2 · see citing works
“These cases may mimic squamous cell carcinoma [16,17] or granulomatous diseases such as sarcoidosis or Wegener’s granulomatosis [18].”
- Authors
- Morán-Mariños, C., Llanos-Tejada, F., Villanueva-Villegas, R., Vargas-Ponce, K. G., & Salas-López, J.
- Affiliations
- Unidad Especializada en Tuberculosis, Servicio de Neumología, Hospital Nacional Dos de Mayo, Lima, Perú
- Hospital Nacional Dos de Mayo (PE)
- Clínica Jesús del Norte, Lima, Perú
- Venue
- Clinical Medicine Insights Case Reports
- Publisher
- SAGE Publications
- Published
- 2024-01
- Volume
- 17
- Pages
- 11795476241251945-11795476241251945
- ISSN
- 1179-5476 (ISSN-L)
- PMC
- PMC11072070
- OpenAlex
- W4396681375
- Cited by
- 1
- References
- 22
- Citations by year
- 2025: 1
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Medicine Insights Case Reports (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Keywords
- pharyngeal tuberculosis, HIV, extrapulmonary tuberculosis, oral ulcers, sore throat, antibiotic use, differential diagnosis of malignancy, tuberculosis treatment, underdiagnosis
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