Depression during exacerbations in multiple sclerosis: the importance of uncertainty
Open accessAbstract
The following correlates of depression were examined in a sample of 166 patients with clinically definite relapsing-remitting (n=140) or secondary progressive (n=26) multiple sclerosis: (a) the present state of the patients' illness (i.e., whether or not they were currently experiencing an exacerbation of their symptoms); (b) their level of uncertainty concerning their illness; and (c) their strategies for coping with their illness. A current exacerbation in symptoms, greater uncertainty of illness, and greater use of emotion-centered forms of coping were all related to depression. Multivariate analyses revealed that uncertainty of illness played a pivotal role as a mediating variable. Exacerbations in illness appeared to heighten patients' levels of uncertainty, and it was largely through this heightened uncertainty that the increases in depression came about.
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People with MS often experience considerable disease course-variability and illness uncertainty, which are associated with emotional distress.
“People with MS often experience considerable disease course-variability and illness uncertainty, which are associated with emotional distress29–31,69.”
From Ecological momentary assessment of pain, fatigue, depressive, and cognitive symptoms reveals significant daily variability in multiple sclerosis (2017) · cites this paper as [30]
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References 29 · Cited by 92
- Authors
- Kroencke, D. C., Denney, D. R., & Lynch, S. G.
- Affiliations
- University of Kansas (US)
- University of Kansas Medical Center (US)
- ORCID
- Lynch, Sharon G
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2001-08
- Volume
- 7
- Issue
- 4
- Pages
- 237-242
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W2163790711
- Cited by
- 92
- References
- 29
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 4 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 3
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Multiple Sclerosis Journal (publishedVersion)
- PubMed (publishedVersion)
- KU ScholarWorks (The University of Kansas) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- depression, multiple sclerosis, relapsing-remitting multiple sclerosis, secondary progressive multiple sclerosis, disease exacerbation, illness uncertainty, coping strategies, emotion-focused coping, mediation
- MeSH terms
- Adaptation, Psychological, Adolescent, Adult, Aged, Depression, Female, Health Status, Humans, Male, Middle Aged, Models, Psychological, Multiple Sclerosis, Probability, Recurrence, Disease Progression, Patient Selection
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