2010 McDonald criteria in a pediatric cohort: is positivity at onset associated with a more aggressive multiple sclerosis course?
Abstract
The 2010 McDonald criteria allow the diagnosis of multiple sclerosis (MS) at first attack in children and adults provided that the first attack symptoms are typical of MS and that the magnetic resonance imaging (MRI) conforms to prescribed features. We evaluate whether meeting the 2010 McDonald criteria at onset correlates with a more aggressive clinical course in a cohort of pediatric MS patients. The Expanded Disability Status Scale (EDSS) and annualized relapse rate were not associated with positivity for 2010 McDonald criteria at onset. The 2010 McDonald criteria identify children with similar MS features to those identified by clinical or MRI evidence of dissemination over time.
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Although ADEM typically is monophasic, some children with ADEM have recurrent clinical episodes and/or MRI evidence of accrual of new lesions, leading to MS diagnosis.
“Although ADEM typically is monophasic, some children with ADEM have recurrent clinical episodes and/or MRI evidence of accrual of new lesions, leading to MS diagnosis. 37”
From Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria (2018) · cites this paper as [37]
Cites
Paediatric multiple sclerosis: examining utility of the McDonald 2010 criteria
Sedani, S., Lim, M., Hemingway, C., Wassmer, E., & Absoud, M. (2012) · Multiple Sclerosis Journal · doi:10.1177/1352458511426815 · Cited by 28 · see citing works
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Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Thompson, A. J., Banwell, B. L., Barkhof, F., Carroll, W. M., Coetzee, T., Comi, G., Correale, J., Fazekas, F., Filippi, M., Freedman, M. S., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30470-2 · Cited by 8,167 · see citing works
Self-citation
- Authors
- Bigi, S., Marrie, R. A., Verhey, L., Yeh, E. A., & Banwell, B.
- Affiliations
- University of Toronto (CA)
- University of Manitoba (CA)
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2013-04-25
- Volume
- 19
- Issue
- 10
- Pages
- 1359-1362
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W2102575453
- Cited by
- 10
- References
- 1
- Citations by year
- 2023: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 3 · 2014: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Multiple Sclerosis Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- pediatric multiple sclerosis, first attack, dissemination in space, clinical course, Expanded Disability Status Scale, annualized relapse rate, MRI findings, disease severity
- MeSH terms
- Central Nervous System, Child, Female, Humans, Magnetic Resonance Imaging, Male, Multiple Sclerosis, Age of Onset, Disease Progression
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